Ana Landa-Magdalena
A5064686076- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- GDF15 and Related Biomarkers
- Liver Diseases and Immunity
- Kruppel-like factors research
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Andrographolide Research and Applications
- Bone Tumor Diagnosis and Treatments
- Urologic and reproductive health conditions
- Immune cells in cancer
- Nuclear Receptors and Signaling
- Genetic and Kidney Cyst Diseases
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Medical Imaging and Pathology Studies
- Ovarian function and disorders
- Macrophage Migration Inhibitory Factor
- Cancer Mechanisms and Therapy
Clinica Universidad de Navarra
2024-2025
Biogipuzkoa Health Research Institute
2020-2022
University of the Basque Country
2020-2022
Ghent University Hospital
2022
Antwerp University Hospital
2022
Centro de Estudios Científicos
1978
Centro Científico Tecnológico - San Juan
1978
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on background of chronic liver injury involving inflammatory hepatic regenerative processes. The triggering receptor expressed myeloid cells 2 (TREM-2) predominantly in non-parenchymal inhibits Toll-like signalling, protecting the from various hepatotoxic injuries, yet its role poorly defined. Here, we investigated impact TREM-2 regeneration hepatocarcinogenesis. Design expression was analysed...
Cancer immunotherapies with antibodies blocking immune checkpoint molecules are clinically active across multiple cancer entities and have markedly improved treatment1. Yet, response rates still limited, tumour progression commonly occurs2. Soluble cell-bound factors in the microenvironment negatively affect immunity. Recently, growth differentiation factor 15 (GDF-15), a cytokine that is abundantly produced by many types, was shown to interfere antitumour response. In preclinical models,...
Abstract Desmoplastic small round cell tumor (DSRCT) is rare and a highly aggressive neoplasm that typically involves the soft tissues of abdomen or pelvis in children young adults, showing male predilection. Although it can occurs over wide age range, peak incidence third decade life. DSRCT usually shows widespread abdominal serosal involvement, overall patient survival poor. On other hand, extra‐abdominal very rare. major salivary glands has been reported, but extremely In majority...
<title>Abstract</title> Cancer immunotherapies with antibodies blocking immune checkpoint molecules are active treatments across multiple cancer entities and have markedly improved treatment. Yet, response rates still limited, tumor progression commonly occurs. Soluble cell-bound factors in the microenvironment negatively impact on immunity. Recently, Growth Differentiation-factor 15 (GDF-15), a cytokine that is abundantly produced by many types, was shown to interfere anti-tumor response....
Background: Cholangiocarcinoma (CCA) is a rare liver cancer; increasing incidence and related mortality highlight an unmet medical need. There scant clinical information in large datasets; this study investigated the course of CCA pan-European cohort.Methods: The European (Euro)-CCA Registry multicenter, observational study. Patients with histologically-proven (sub-classified as intrahepatic (iCCA), perihilar (pCCA) or distal (dCCA)) diagnosed between 2010-2019, from 26 hospitals 11...