A5086171008- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Bone and Dental Protein Studies
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Aortic aneurysm repair treatments
- Cancer, Hypoxia, and Metabolism
- Vascular Procedures and Complications
- Colorectal Cancer Treatments and Studies
- Digestive system and related health
- Hepatitis C virus research
Vienna General Hospital
2020-2023
Medical University of Vienna
2020-2023
Moffitt Cancer Center
2020
Platelet-stored serotonin critically affects liver regeneration in mice and humans. Selective reuptake inhibitors (SSRIs) noradrenalin (SNRIs) reduce intraplatelet serotonin. As SSRIs/SNRIs are now one of the most commonly prescribed drugs United States Europe given serotonin's impact on regeneration, we evaluated whether perioperative use outcome after hepatic resection.Consecutive patients undergoing resection (n = 754) were retrospectively included from prospectively maintained databases...
AXL and its corresponding ligand growth arrest-specific 6 (GAS-6) are critically involved in hepatic immunomodulation regenerative processes. Pleiotropic inhibitory effects on innate inflammatory responses might essentially involve the shift of macrophage phenotype from a pro-inflammatory M1 to an anti-inflammatory M2. We aimed assess relevance AXL/GAS-6-pathway human liver regeneration and, consequently, association with clinical outcome after resection. Soluble (sAXL) GAS-6 levels were...
Abdominal aortic aneurysm (AAA) and peripheral artery disease (PAD) share pathophysiological mechanisms including the activation of fibrinolytic innate immune system, which explains analysis D-dimer myeloperoxidase (MPO) in both conditions. This study evaluates diagnostic marker potential variables separately as a combined MPO/D-dimer score for identifying patients with AAA versus healthy individuals or PAD. Plasma levels MPO were increased PAD compared to controls (median MPO: 13.63 ng/mL...