A5011832388- Ion Channels and Receptors
- Ion channel regulation and function
- Drug Transport and Resistance Mechanisms
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- RNA regulation and disease
- interferon and immune responses
- Ion Transport and Channel Regulation
- Bone and Dental Protein Studies
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Genetic and Kidney Cyst Diseases
- Immune Cell Function and Interaction
- South Asian Studies and Conflicts
- Calcium signaling and nucleotide metabolism
- RNA modifications and cancer
- Immune Response and Inflammation
- Sympathectomy and Hyperhidrosis Treatments
- Salivary Gland Disorders and Functions
- Herbal Medicine Research Studies
- Cancer Cells and Metastasis
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
University of Chicago
2024-2025
University of Chicago Medicine Comprehensive Cancer Center
2024
University Medical Center Utrecht
2024
New York University
2015-2023
Universidad de Navarra
2011-2017
Instituto de Salud Carlos III
2014
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013-2014
University of Wisconsin–Madison
2008
The University of Texas Medical Branch at Galveston
2008
Science Applications International Corporation (United States)
2008
Cholestasis is associated with increased liver injury and morbidity after partial hepatectomy (PH), yet bile acids (BAs) are emerging as important mediators of regeneration. Fibroblast growth factor 15 (Fgf15, human FGF19) a BA-induced ileum-derived enterokine that governs BA metabolism. We evaluated the relevance Fgf15 in preservation homeostasis PH its potential role regenerative process.Liver regeneration was studied (-/-) (+/+) mice. The effects sequestrant cholestyramine adenovirally...
Store-operated Ca(2+) entry (SOCE) through release-activated (CRAC) channels is essential for immunity to infection. CRAC are formed by ORAI1 proteins in the plasma membrane and activated stromal interaction molecule (STIM)1 STIM2 endoplasmic reticulum. Mutations STIM1 genes that abolish SOCE cause severe immunodeficiency with recurrent infections due impaired T cell function. has also been observed cells of innate immune system such as macrophages dendritic (DCs) may provide signals...
Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations the Ca2+ release-activated (CRAC) channel genes ORAI1 STIM1 abolish store-operated entry (SOCE), patients with these CRAC suffer from anhidrosis hyperthermia at high ambient temperatures. Here we have shown that channel-deficient mice ectodermal tissue-specific deletion of Orai1 (Orai1K14Cre) or Stim1 Stim2 (Stim1/2K14Cre) failed to despite normal gland development. SOCE was absent...
Abstract TCR stimulation triggers Ca 2+ signals that are critical for T cell function and immunity. Several pore-forming α auxiliary β subunits of voltage-gated channels (VGCC) were reported in cells, but their mechanism activation remains elusive contribution to signaling cells is controversial. We here identify V β1, encoded by Cacnb1 , as a regulator function. deletion enhances apoptosis impairs the clonal expansion after lymphocytic choriomeningitis virus (LCMV) infection. By contrast,...
The mechanisms by which excessive fluoride causes defects in tooth enamel mineralization are revealed.
Article1 July 2020Open Access Source Data STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells Sascha Kahlfuss orcid.org/0000-0001-8813-1061 Department Pathology, New York University Grossman School Medicine, York, NY, USA Search for more papers by this author Ulrike Kaufmann Axel R Concepcion Lucile Noyer Dimitrius Raphael Martin Vaeth Jun Yang Priya Pancholi Mate Maus James Muller Lina Kozhaya The Jackson Laboratory Genomic...
Abstract Dental enamel formation requires large quantities of Ca 2+ yet the mechanisms mediating dynamics in cells are unclear. Store-operated entry (SOCE) channels important influx many cells. SOCE involves release from intracellular pools followed by entry. The best-characterized release-activated (CRAC) channels. As patients with mutations CRAC channel genes STIM1 and ORAI1 show abnormal mineralization, we hypothesized that might be an uptake mechanism Investigating primary murine cells,...
Mitogenic stimulation of lymphocytes involves alkalinization intracellular pH (pHi ). Subsequent pHi regulation may involve HCO3 (-) extrusion through Cl(-) /HCO3 exchangers and/or Na(+) -HCO3 co-transporters with acid-loading capability. Abnormalities in these mechanisms could result immune dysfunctions, as suggested by the CD8(+) T-cell expansion encountered mice lacking Ae2 (a widely expressed acid loader electroneutral and -independent anion-exchange activity). Here we report that T...
// Axel R. Concepcion 1 , January T. Salas 2 Elena Sáez Sarai Sarvide Alex Ferrer 3 Ainhoa Portu Iker Uriarte Sandra Hervás-Stubbs Ronald P.J. Oude Elferink 4 Jesús Prieto and Juan F. Medina Center for Applied Medical Research (CIMA), School of Medicine Clinic University Navarra, Ciberehd, Pamplona, Spain Department Pathology Laboratory Medicine, Pennsylvania Perelman Philadelphia, PA, USA Immunology, Mayo College Rochester, MN, Tytgat Institute Liver Intestinal Research, Academic Center,...
Regulatory T (Treg) cells can weaken antitumor immune responses, and inhibition of their function appears to be a promising therapeutic approach in cancer patients. Mice with targeted deletion the gene encoding Cl-/HCO3- anion exchanger AE2 (also termed SLC4A2), membrane-bound carrier involved intracellular pH regulation, showed progressive decrease number Treg cells. We therefore challenged as potential target for tumor therapy, generated linear peptides designed bind third extracellular...
<h3>Background:</h3> The combination of leflunomide and hydroxychloroquine (LEF-HCQ) has emerged as a potential therapy for Sjögren's disease. Given the variability in patient responses, comprehending action mechanisms this treatment complex pathophysiology disease is vital developing personalized strategies. <h3>Objectives:</h3> To examine large-scale serum proteomic profiles healthy individuals versus patients with primary (pSD) undergoing LEF-HCQ treatment, to delineate dissimilarities...
Sympathetic nerves co-develop with their target organs and release neurotransmitters to stimulate functions after maturation. Here, we provide the molecular mechanism that during sweat gland morphogenesis, released from sympathetic act first promote duct elongation via norepinephrine followed by acetylcholine specify stem cell fate, which matches sequence of neurotransmitter switch. Without neuronal signals development, basal cells switch exhibit suprabasal (luminal) features. Sarcolipin...