A5031996070- ATP Synthase and ATPases Research
- Cytokine Signaling Pathways and Interactions
- Mitochondrial Function and Pathology
- Effects and risks of endocrine disrupting chemicals
- Prostate Cancer Treatment and Research
- Bioinformatics and Genomic Networks
- Protein Structure and Dynamics
- Hops Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Toxic Organic Pollutants Impact
- S100 Proteins and Annexins
- Carcinogens and Genotoxicity Assessment
- Toxin Mechanisms and Immunotoxins
- Estrogen and related hormone effects
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA modifications and cancer
- RNA Research and Splicing
- Metabolism and Genetic Disorders
Neuroscience Institute
2021-2023
National Research Council
2021
Istituto Pasteur
2019
Sapienza University of Rome
2018
The mitochondrial protein IF1 binds to the catalytic domain of ATP synthase and inhibits hydrolysis in ischemic tissues. Moreover, is overexpressed many tumors has been shown act as a pro-oncogenic protein, although its mechanism action still debated. Here, we show that ATP5IF1 gene disruption HeLa cells decreases colony formation soft agar tumor mass development xenografts, underlining role cancer. Notably, lack does not affect proliferation or oligomycin-sensitive respiration, but it...
A hydroalcoholic extract from female inflorescences of Humulus lupulus L. (HOP extract) was evaluated for its anti-influenza activity. The ability the to interfere with different phases viral replication assessed, as well effect on intracellular redox state, being unbalanced versus oxidative state in infected cells. radical scavenging power, inhibition lipoperoxidation, and ferric reducing activity were assayed antioxidant mechanisms. phytochemical characterization also performed. We found...
STAT3 is an oncoprotein overexpressed in different types of tumors, including prostate cancer (PCa), and its activity modulated by a variety post-translational modifications (PTMs). Prostate represents the most common diagnosed men, each phase tumor progression displays specific cellular conditions: inflammation predominant tumor's early stage, whereas oxidative stress typical clinically advanced PCa. The aim this research to assess correspondence between stimulus-specificity PTMs definite...
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with molecular mechanisms of endocrine disruption. Among OCPs, particular attention was focused on effects β-hexaclorocyclohexane (β-HCH), a common pollutant. A detailed epidemiological study carried out exposed population “Valle del Sacco” found correlations between incidence wide range diseases occurrence β-HCH contamination. Taking into account pleiotropic role...