A5088078847- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Adrenal Hormones and Disorders
- Testicular diseases and treatments
- Sexual Differentiation and Disorders
- Reproductive Health and Technologies
- Stress Responses and Cortisol
- Sexual function and dysfunction studies
- Pituitary Gland Disorders and Treatments
- Ovarian function and disorders
- Hormonal Regulation and Hypertension
- LGBTQ Health, Identity, and Policy
- Youth Substance Use and School Attendance
- Organ and Tissue Transplantation Research
- Homelessness and Social Issues
- Business Strategy and Innovation
- Intellectual Capital and Performance Analysis
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- HIV-related health complications and treatments
- Diabetes Treatment and Management
- Electrochemical sensors and biosensors
- Youth Education and Societal Dynamics
Sapienza University of Rome
2011-2025
Policlinico Umberto I
2023
Champlain College
2018
Instituto di Biofisica
1993
Abstract Purpose While SARS-CoV-2 infection appears not to be clinically evident in the testes, indirect inflammatory effects and fever may impair testicular function. To date, few long-term data of semen parameters impairment after recovery comprehensive andrological evaluation recovered patients has been published. The purpose this study was investigate whether affect male reproductive health. Methods Eighty were recruited three months COVID-19 recovery. They performed physical...
STUDY QUESTIONIs spermatogenesis impairment caused by Hodgkin's lymphoma (HL) itself or the various treatments?
Cyclic nucleotides are critical regulators of adaptive thermogenesis and adipogenesis, with their intracellular levels finely tuned by phosphodiesterases. Phosphodiesterase type 5 (PDE5A) modulates cyclic guanosine monophosphate in adipocytes. While PDE5A inhibition has shown promise patients diabetes, its role metabolism remains unclear. Using Pde5a knockout mouse models, we demonstrated that mice lacking exhibit enhanced browning white adipose tissue reduced hepatic fat content. Following...
The Italian debate on territorial healthcare is currently focused the implementation of various measures under National Recovery and Resilience Plan (PNRR), particularly Mission 6 Health, aimed at enhancing human resources services. This paper examines, from an ex-ante perspective, potential capability regional health institutions using input-output framework applied to personnel classified by socio-demographic characteristics. analysis draws two key official data sources: Annual Accounts...
Abstract Introduction Medical therapy for Cushing's syndrome (CS) typically aims to reduce daily cortisol output without addressing circadian rhythm restoration. No licensed drugs target this objective. We investigated the efficacy and safety of timed, once-daily osilodrostat administration in improving profiles CS. Methods A prospective, multicenter study evaluated patients with well-controlled CS on a stable twice-daily before 60-90 days after transitioning single equivalent dose at 19:00...
Summary The aim of this study was to investigate sperm DNA damage induced by chemo‐ and radiotherapy in patients with testicular cancer provide data on the extent persistence nuclear that might affect individual reproductive potential. We evaluated pre‐ post‐antineoplastic treatment integrity, expressed as Fragmentation Index ( DFI ), a large caseload chromatin structure assay. mean total for all at T0 18.0 ± 12.5%. Sperm profile markedly impaired T3 (27.7 17.4%) T6 (23.2 15.3%), improving...
Varicocele is a vascular disease characterised by the abnormal enlargement of pampiniform plexus veins and well-known cause male infertility. The aim this study was to investigate relationship between sperm DNA fragmentation (SDF) inflammation in pathogenesis varicocele. We included 84 varicocele patients 85 normozoospermic healthy controls, further analysed according body mass index, smoking habit (smokers/non-smokers) severity (low/high grade). Semen parameters, SDF (by TUNEL) inflammatory...
Summary Testicular cancer ( TC ) is currently the most common malignant solid tumour in Caucasian males aged 15–39 years. Epidemiological evidence suggests that its onset may be due to an imbalance action of steroidal sex hormones and their receptors. A faulty androgen receptor signalling pathway can, fact, cause various male reproductive disorders. The AR gene has two polymorphic segments consisting CAG GGC repeats. length repeats been shown affect regulation activity. In our study, we used...
Chronic prostatitis (CP) is one of the most common male urogenital diseases and a significant public health problem in industrialised countries. It associated with low quality life expense. Given poor results achieved antibiotics, scientific interest has turned to use natural substances known activity on prostate function. The aim our study was evaluate effect new dietary supplement containing lycopene, epigallocatechin gallate, ellagic acid, selenium zinc semen parameters leucocyte...
This article provides an interdisciplinary exploration of the ways in which social isolation is constructed institutional and public imaginaries. It examines discursive devices that produce hikikomori subjectivities, with a particular focus on existence enduring deviant construct. Despite largely existing private sphere, are positioned as residing outside prevailing system relationships such perceived threat to order. Persistent psycho-medical idiosyncratic cultural depictions continue...
Virilization of gender-incongruent subjects to whom were assigned the female gender at birth (AFAB) is achieved through testosterone administration. Inter-individual differences in timing and acquisition phenotypic characteristics, even if same hormone preparations regimens are used, frequently observed. Polymorphisms sex receptors methylation their gene promoters, as well several imprinted genes H19, may underlie differential response treatment. Thus, aim this study was examine possible...
Testicular germ cell tumours (TGCTs) is the most common malignancy among young adult males. The etiology multifactorial and both environmental genetic factors play an important role in origin development of TGCT. Genetic susceptibility may result from interaction multiple low-penetrance variants one main candidate genes PDE11A. Many PDE11A polymorphisms were found responsible for a reduced PDE activity TGCT patients, who often also display impaired hormone sperm profile. aim this study was...
Intracytoplasmic sperm injection was performed with immotile spermatozoa affected by tail 'stump' defect, and resulted in normal fertilization, embryo transfer pregnancy a 35-year-old female. The husband had consanguineous ancestry. Two healthy babies, male female, were born this confirms that infertility due to certain genetic defects can be overcome the intracytoplasmic injection-assisted reproduction technique. likely origin of defect probability offspring inheriting should considered....
This paper describes the development of a simple voltammetric biosensor for stereoselective discrimination myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) by means bovine serum albumin (BSA) adsorption onto multi-walled carbon nanotube (MWCNT) graphite screen-printed electrode (MWCNT-GSPE), previously functionalized electropolymerization methylene blue (MB). After morphological characterization, enantioselective platform was electrochemically characterized after each modification...
During the COVID-19 pandemic, most severe form of disease was often seen in male patients. The aim this study to identify any predispositions that could be used predict outcome and enable early intervention. We investigated CAG polymorphism androgen receptor gene serum levels testosterone LH, which were considered as probably responsible for predisposition. involved 142 patients who had recovered from at least three months previously classified according their severity using World Health...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Purpose Sexual dysfunctions are often experienced by male patients with acromegaly, due to a combination of hypogonadism and other comorbidities, but scarcely investigated complication. Erectile dysfunction is also closely related cardiovascular diseases through endothelial dysfunction. Therefore, this project aimed assess the prevalence erectile in population acromegalic men evaluate its association cardio-metabolic disorders, exploring associations androgen estrogen receptor gene...
Acromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates pro-inflammatory state, but exact mechanisms which GH or insulin-like factor 1 (IGF-I) act on inflammatory cells are not fully understood. Aim study was to evaluate Interleukin-33 (IL33) and D-series resolvins (RvD1) skin perfusion hands in patients with acromegaly (AP) healthy controls (HC).IL33 RvD1 have been assessed 20 AP HC. Nailfold videocapillaroscopy (NVC) performed laser speckle...