A5048666084- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Parvovirus B19 Infection Studies
- Ovarian cancer diagnosis and treatment
- Herpesvirus Infections and Treatments
- Metabolism and Genetic Disorders
- Fibroblast Growth Factor Research
- Histiocytic Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- SARS-CoV-2 detection and testing
- Neonatal Health and Biochemistry
- Endometriosis Research and Treatment
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Reproductive System and Pregnancy
- Diet, Metabolism, and Disease
- Electrochemical sensors and biosensors
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Kruppel-like factors research
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2016-2025
The Patients Association
2022
E Ink (South Korea)
2022
Istituto Pasteur
2003-2020
Hudson Institute
2020
John Wiley & Sons (United States)
2020
University of Catania
2009
Istituto Superiore di Sanità
1997-2005
University of Cagliari
2004
The present study was designed to evaluate the clinical outcome of cell-based therapy with cultured adipose derived stromal cells (ASCs) for treatment cutaneous manifestations in patients affected by systemic sclerosis (SSc). ASCs have an extraordinary developmental plasticity, including ability undergo multilineage differentiation and self-renewal. Moreover, can be easily harvested from small volumes liposuction aspirate, showing great vitro viability proliferation rate. Here we isolated,...
A significant number of COVID-19 patients were shown to have neutralizing antibodies (NAB) against IFN; however, NAB specificity, fluctuation over time, associations with biochemical and hematological parameters, IFN gene expression are not well characterized. Binding (BAB) IFN-α/-β screened in patients' serum. All BAB positive sera, a subset respiratory samples, tested for IFN-α/-β/-ω, using an antiviral bioassay. Transcript levels IFN-α/-β/-ω IFN-stimulated genes (ISGs) quantified....
Adipose-derived mesenchymal stem cells (ASCs) are commonly employed in clinical treatment for various diseases due to their ability differentiate into multi-lineage and anti-inflammatory/immunomodulatory properties. Preclinical studies support use bone regeneration, healing, the improvement of functional outcomes. However, a deeper understanding molecular mechanisms underlying ASC biology is crucial identifying key regulatory pathways that influence differentiation enhance regenerative...
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into genetic architecture NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 TM6SF2 were resequenced by next generation sequencing in cohort 218 subjects 227 controls, where PNPLA3 rs738409 MBOAT7 rs641738 genotypes also obtained. A total 168 sequence variants detected 47 annotated as functional. When all functional within each gene...
Abstract Background Ovarian cancer (OC) is the most lethal gynecological malignancy and second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but resistance may occur underlying mechanisms are still poorly understood. The aim this study to identify target genes within tumor cells that might Olaparib. We focused on Neuropilin 1 (NRP1), a transmembrane receptor expressed correlated poor...
Click to increase image sizeClick decrease size Disclosure statementNo potential conflict of interest was reported by the author(s).
Urinary tract infections (UTIs) are mainly caused by uropathogenic
Obesity is associated with a poor COVID-19 prognosis, and it seems reduced humoral response to vaccination. Public health campaigns have advocated for weight loss in subjects obesity, hoping eliminate this risk. However, no evidence proves that leads better prognosis or stronger immune We aimed investigate the impact of rapid on adaptive morbid obesity. Twenty-one patients followed hypocaloric, very-low-carbohydrate diet one week before after two mRNA vaccine doses. The diet's safety...
Newborn screening (NBS) for inborn errors of metabolism is one the most advanced tools secondary prevention in medicine, as it allows early diagnosis and prompt treatment initiation. The expanded newborn was introduced Italy between 2016 2017 (Law 167/2016; DM 13 October 2016; DPCM 12-1-2017). A total 1,586,578 infants born were screened January December 2020. For this survey, we collected data from 15 Italian laboratories, focusing on metabolic disorders identified by tandem mass...
Background Spinal muscular atrophy (SMA) is due to the homozygous absence of SMN1 in around 97% patients, independent severity (classically ranked into types I–III). The high genetic homogeneity, coupled with excellent results presymptomatic treatments patients each three disease-modifying therapies available, makes SMA one golden candidates newborn screening (NBS) (SMA-NBS). implementation NBS national programmes occurring some countries an arising new issue that scientific community has...
Background and Methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 9 the neurofilament light chain (NFL) pathways. Thus, aim of this pilot study was investigate BDNF, MMP-2, MMP-9, NFL serum men affected at beginning hospitalization period characterized different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) with fatal...
The global rise of single-use throw-away plastic products has elicited a massive increase in the nano/microplastics (N/MPLs) exposure burden humans. Recently, it been demonstrated that disposable period may release N/MPLs with usage, which represents potential threat to women's health not scientifically addressed yet. By using polyethyl ene (PE) particles (200 nm 9 μm), we showed acute high concentration induced cell toxicity vaginal keratinocytes after effective cellular uptake, as...
We have reported in the accompanying paper that BFRF1 protein of Epstein-Barr virus (EBV) is important for efficient primary viral envelopment and egress (A. Farina, R. Feederle, S. Raffa, Gonnella, Santarelli, L. Frati, A. Angeloni, M. Torrisi, Faggioni, H.-J. Delecluse, J. Virol. 79:3703-3712). Here we describe characterization product EBV BFLF2 gene, which belongs to a family conserved herpesviral genes include UL31 herpes simplex pseudorabies whose products are known interact with UL34,...
A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV-8) was conducted in Sardinia, one the world's highest incidence areas classic Kaposi's sarcoma (KS). Prevalence HHV-8 sVCA greatest patients with KS (95%), followed by family members (39%) and Sardinian control population age- sex-matched relatives (11%). Within families, prevalence about equal among spouses, children, siblings patients, finding that raises possibilities intrafamilial...
The molecular mechanisms that underlie maturation and egress of Epstein-Barr virus (EBV) virions are only partially characterized. We have recently shown the BFRF1 gene, EBV positional homolog herpes simplex type 1 pseudorabies UL34, is expressed early during lytic replication it found predominantly on nuclear membrane (A. Farina, R. Santarelli, Gonnella, Bei, Muraro, G. Cardinali, S. Uccini, Ragona, L. Frati, A. Faggioni, Angeloni, J. Virol. 74:3235-3244, 2000). These data suggest protein...
COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, virus belonging to the Coronaviridae family. This has spread rapidly around world and soon became an international public health emergency leading unpredicted pressure on hospital units. Early routine blood biomarkers could be key predicting factors of morbidity mortality as suggested for C-reactive protein (CRP), IL-6, prothrombin D-dimer. study aims identify other early severity prediction disclosed directly into...
Endometriosis is a chronic, estrogen-dependent, inflammatory disease, whose pivotal symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain (CPP). Besides the usual medical treatments, recent evidence suggests there potential benefits of oral N-acetylcysteine (NAC) on endometriotic lesions pain. The primary objective this prospective single-cohort study was to confirm effectiveness NAC in reducing endometriosis-related size ovarian endometriomas. secondary assess if may play role...
Hematological malignancies such as Burkitt lymphoma (BL), Hodgkin (HL), and diffuse large B-cell (DLBCL) cause significant morbidity in humans. A substantial number of these lymphomas, particularly HL DLBCLs have poorer prognosis because their association with Epstein-Barr virus (EBV). Our earlier studies shown that EBV-encoded nuclear antigen (EBNA2) upregulates programmed cell death ligand 1 DLBCL BLs by downregulating microRNA-34a. Here, we investigated whether EBNA2 affects the inducible...