A5058534895- Diabetes and associated disorders
- Ovarian cancer diagnosis and treatment
- Pancreatic function and diabetes
- Endometriosis Research and Treatment
- Diabetes Management and Research
- SARS-CoV-2 and COVID-19 Research
- Endometrial and Cervical Cancer Treatments
- COVID-19 Clinical Research Studies
- Uterine Myomas and Treatments
- Neuroendocrine Tumor Research Advances
- Vitamin D Research Studies
- Digestive system and related health
- Pancreatic and Hepatic Oncology Research
- Celiac Disease Research and Management
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Intraperitoneal and Appendiceal Malignancies
- Ovarian function and disorders
- Metabolism, Diabetes, and Cancer
- Urinary and Genital Oncology Studies
Sapienza University of Rome
2015-2025
Policlinico Umberto I
2014-2024
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Istituto di Sessuologia Clinica
1997
Joslin Diabetes Center
1988-1993
Harvard University
1988-1993
University of Massachusetts Chan Medical School
1993
Magna Graecia University
1993
University of Messina
1993
Human epididymis protein 4 (HE4) has recently been described as a new marker for the early diagnosis of ovarian cancer (OC). The objective this study was to evaluate (a) expression HE4 vs. OC mucin CA125 in 32 patients with compared 163 other malignant or benign pathologies (b) indicator recurrence disease eight followed-up 20 months after diagnosis. Serum and CA 125 levels were determined by ELISA IRMA, respectively. At diagnosis, demonstrated high both biomarkers 96.9% sensitivity 85.7%...
Click to increase image sizeClick decrease size Disclosure statementNo potential conflict of interest was reported by the author(s).
Obesity is associated with a poor COVID-19 prognosis, and it seems reduced humoral response to vaccination. Public health campaigns have advocated for weight loss in subjects obesity, hoping eliminate this risk. However, no evidence proves that leads better prognosis or stronger immune We aimed investigate the impact of rapid on adaptive morbid obesity. Twenty-one patients followed hypocaloric, very-low-carbohydrate diet one week before after two mRNA vaccine doses. The diet's safety...
Abstract Thymic-derived dysregulated tolerance has been suggested to occur in type 1 diabetes via impaired generation of CD4+CD25+ T regulatory cells, leading autoimmune β cell destruction. In this study, we demonstrate that Notch3 expression is a characteristic feature cells. Furthermore, streptozotocin-induced fails develop transgenic mice carrying the constitutively active intracellular domain thymocytes and The failure disease associated with an increase accumulating lymphoid organs,...
OBJECTIVE: It is well known that a high number of celiac patients may develop autoantibodies against endocrine glands, but it has not yet been clarified if this increased autoimmune response and the impaired organ function can be related to presence or absence gluten in diet. The aim present study was evaluate effect on autoimmunity glands adolescent patients. METHODS: To clarify aspect we investigated 44 (28 females), aged 11–20 yr (15.21 ± 2.7 yr): 25 (mean age, 15.1 2.2 yr) gluten-free...
The aim of this study was to investigate the role biomarkers CA125, HE4, and CA72.4 at diagnosis throughout follow-up in patients with epithelial ovarian cancer (EOC). Thirty-nine EOC were deemed eligible, 20 followed up. serum levels determined for all initial EOC. Among these patients, number cases an elevated level each individual marker CA125 77 %, HE4 85 72 %. A statistically significant difference observed between when compared (p < 0.02). In phase, we tumor fluctuating according...
Endometriosis is frequently associated with high levels of CA125. This marker therefore not useful for discriminating ovarian endometrioma from malignancy. The aim this study was to establish a panel complementary biomarkers that could be helpful in the differential diagnosis between endometriosis or other benign masses and cancer.Blood samples 50 healthy women, 17 patients tumors, 57 39 cancer were analyzed serum values measured following biomarkers: CA125, HE4 CA72-4.Serum CA125...
Endometriosis is a chronic, estrogen-dependent, inflammatory disease, whose pivotal symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain (CPP). Besides the usual medical treatments, recent evidence suggests there potential benefits of oral N-acetylcysteine (NAC) on endometriotic lesions pain. The primary objective this prospective single-cohort study was to confirm effectiveness NAC in reducing endometriosis-related size ovarian endometriomas. secondary assess if may play role...
To quantify the circulating levels of novel serum biomarkers including GDF-15, PIVKA-II, sdLDL, suPAR, and CRP in hospitalized COVID-19 patients compared with healthy subjects, to evaluate their association(s) outcomes COVID-19. We considered confirmed COVID-19, an Internal Medicine ward. The clinical characteristics were collected, number type comorbidities. Serum as well measured. As outcomes, we Intensive Care Unit (ICU) transfer or death, length stay (days) in-hospital complications....
The intestinal hormone glucagon-like peptide-1 (GLP-1) has been shown to promote an increase in pancreatic beta-cell mass via proliferation of islet cells and differentiation non-insulin-secreting cells. In this study, we have characterized some the events that lead ductal response treatment with human GLP-1. Rat (ARIP) were cultured presence GLP-1 analyzed for cell counting, cycle distribution, expression cyclin-dependent-kinase (Cdk) inhibitors, transcription beta-cell-specific genes, loss...
The objective of the present study was to investigate in healthy young women fluctuations serum concentration human epididymal secretory protein epididymis-specific 4 (HE4) and CA125 during phases menstrual cycle correlation between HE4 values age. Forty with regular cycles were included study. Pelvic transvaginal ultrasound performed order exclude ovarian pathologies. Blood samples collected at follicular (FP), ovulatory (OP), luteal (LP) hormonal cycle. (expressed as picomoles per liter)...
The objective of this study is to analyze magnetic resonance imaging shrinkage pattern tumor regression after neoadjuvant chemotherapy and evaluate its relationship with biological subtypes pathological response. We reviewed the studies 51 patients single mass-enhancing lesions (performed at time 0 II last cycles chemotherapy). Tumors were classified as Luminal A, B, HER2+, Triple Negative based on immunohistochemical analysis core needle biopsy. pattern, morphology cycle, concentric,...
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite extensive interest SARS-CoV-2 research, clinical course maternal infection, vertical transmission and neonatal outcomes have not been completely understood yet. The aim our study was investigate association between obstetric transmission....
Type 2 diabetes is characterized by peripheral insulin resistance, pancreatic β-cells dysfunction, and decreased β-cell mass with increased rate of apoptosis. Chronic exposure to high levels free fatty acids (FFAs) has detrimental effects on function survival. FFAs have adverse mitochondrial function, a consequent increase in the production reactive oxygen species. Hepatocyte growth factor (HGF) plays critical role promoting In present study, we investigated whether HGF was capable...
Tumor markers are commonly used to detect a relapse of disease in oncologic patients during follow-up. It is important evaluate new assay systems for better and more precise assessment, as standardized method currently lacking. The aim this study was assess the concordance between an automated chemiluminescent enzyme immunoassay system (LUMIPULSE® G1200) our reference methods using seven tumor markers. Serum samples from 787 subjects representing variety diagnoses, including oncologic, were...
Pancreatic ductal adenocarcinoma (PDAC) represents a highly aggressive malignancy with lack of reliable diagnostic biomarkers. Protein induced by vitamin K absence (PIVKA-II) is protein increased in various cancers (particularly hepatocellular carcinoma), and it has recently exhibited superior performance PDAC detection compared to other The aim our research was identify an vitro model study PIVKA-II production, distribution, release PDAC. We examined the presence panel stabilized pancreatic...