A5056985450- Gut microbiota and health
- Advanced Sensor and Energy Harvesting Materials
- Microbial Metabolites in Food Biotechnology
- Dental Radiography and Imaging
- Graphene and Nanomaterials Applications
- Genetics, Aging, and Longevity in Model Organisms
- Hepatitis B Virus Studies
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Dental materials and restorations
- Diet and metabolism studies
- Tryptophan and brain disorders
- Advanced Nanomaterials in Catalysis
- Probiotics and Fermented Foods
- Autophagy in Disease and Therapy
- Endodontics and Root Canal Treatments
- Pancreatic function and diabetes
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
Policlinico Umberto I
2022-2024
Sapienza University of Rome
2021-2024
Calcium silicate-based cements have reached excellent levels of performance in endodontics, providing predictable and successful results. To better assess the properties these bioactive materials, present study aimed to compare biocompatibility antibiofilm ProRoot MTA Biodentine. Human osteogenic sarcoma (Saos-2) cells were cultured on Biodentine samples or presence both cement extracts. Cell viability assay, measurement reactive oxygen species (ROS), immunofluorescence analysis, as well...
Nanomaterials are gaining increasing attention as innovative materials in medicine. Among nanomaterials, zinc oxide (ZnO) nanostructures particularly appealing because of their opto-electrical, antimicrobial, and photochemical properties. Although ZnO is recognized a safe material the Zn ion (Zn2+) concentration strictly regulated at cellular systemic level, different studies have demonstrated toxicity nanoparticles (ZnO-NPs) nanorods (ZnO-NRs). Recently, ZnO-NP has been shown to depend on...
Pancreatic ductal adenocarcinoma (PDAC) represents a highly aggressive malignancy with lack of reliable diagnostic biomarkers. Protein induced by vitamin K absence (PIVKA-II) is protein increased in various cancers (particularly hepatocellular carcinoma), and it has recently exhibited superior performance PDAC detection compared to other The aim our research was identify an vitro model study PIVKA-II production, distribution, release PDAC. We examined the presence panel stabilized pancreatic...
High levels of 2-hydroxyisobutyric acid (2-HIBA) were found in urines patients with obesity and hepatic steatosis, suggesting a potential involvement this metabolite clinical conditions. The gut microbial origin 2-HIBA was hypothesized, however its actual role biological processes are still not clear. We investigated how treatment affected the physiology model organism Caenorhabditis elegans, both standard high-glucose diet (HGD) growth conditions, by targeted transcriptomic metabolomic...
Lactic acid bacteria (LAB) share several beneficial effects on human organisms, such as bioactive metabolites' release, pathogens' competition and immune stimulation. This study aimed at determining the probiotic potential of autochthonous lactic isolated from carrots. In particular, work reported characterization species level four LAB strains deriving carrots harvested in Fucino highland, Abruzzo (Italy). Ribosomal 16S DNA analysis allowed identification three belonging to...
To produce clothes made with engineered fabrics to monitor the physiological parameters of workers, strain sensors were produced by depositing two different types water-based inks (P1 and P2) suitably mixed graphene nanoplatelets (GNPs) on a fabric. We evaluated biocompatibility GNPs (GNP fabric) through in vitro vivo assays. investigated effects induced human keratinocytes eluates extracted from GNP contact cells seeding directly onto using cell viability test morphological analysis....
Microglial cells polarized towards a proinflammatory phenotype are considered the main cellular players of neuroinflammation, underlying several neurodegenerative diseases. Many studies have suggested that imbalance gut microbial composition is associated with an increase in pro-inflammatory cytokines and oxidative stress underlie chronic neuroinflammatory diseases, perturbations to microbiota were detected conditions such as Parkinson's disease Alzheimer's disease. The importance gut-brain...
Wearable systems have become an integral part of our daily lives. Scientific research has succeeded in integrating various for monitoring human physiological parameters, such as heart rate, respiration, sweating, and more. In this context, the proposed work focuses on study, design, development innovative wearable sensor based graphene. The device was produced using a screen-printing ink filled with graphene nanoplatelets it integrated into fabric through transfer printing process....