A5078424217- Graphene and Nanomaterials Applications
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Graphene research and applications
- Complement system in diseases
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Biomarkers in Disease Mechanisms
- Neuroblastoma Research and Treatments
- Pregnancy and preeclampsia studies
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Carbon and Quantum Dots Applications
- Patient Satisfaction in Healthcare
- Autophagy in Disease and Therapy
- SARS-CoV-2 detection and testing
- Reliability and Agreement in Measurement
- Antiplatelet Therapy and Cardiovascular Diseases
- Organizational Leadership and Management Strategies
- Blood Coagulation and Thrombosis Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Intramuscular injections and effects
Sapienza University of Rome
2012-2024
University of Rome Tor Vergata
2023
Universität Innsbruck
1999-2000
Temple University
1990
Since graphene nanoparticles are attracting increasing interest in relation to medical applications, it is important understand their potential effects on humans. In the present study, we prepared oxide (GO) nanoribbons by oxidative unzipping of single-wall carbon nanotubes (SWCNTs) and analyzed toxicity two human neuroblastoma cell lines. Neuroblastoma most common solid neoplasia children. The hallmark these tumors high number different clinical variables, ranging from highly metastatic,...
In this work, the authors prepared and characterized two different graphene oxides: one chemically synthesized (GO sample) other electrochemically (LiCl) ). Both samples were fully with atomic force microscopy (AFM), Raman Fourier transform infrared (FTIR) spectroscopies, X-ray photo electron spectroscopy (XPS), thermal analysis (TG/DTA), and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi fontfamily="Gadugi">Z</mml:mi></mml:math>-potential. The antibacterial...
High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm, and extracellular space. It important DAMP molecule allows communication between damaged or tumor cells immune system. Tumor exploit HMGB1’s ability to activate intracellular pathways lead cell growth migration. Papillary thyroid cancer a well-differentiated often used study relationships inflammatory microenvironment as latter characterized by high levels of cytokines. Anaplastic...
Nanomaterials are gaining increasing attention as innovative materials in medicine. Among nanomaterials, zinc oxide (ZnO) nanostructures particularly appealing because of their opto-electrical, antimicrobial, and photochemical properties. Although ZnO is recognized a safe material the Zn ion (Zn2+) concentration strictly regulated at cellular systemic level, different studies have demonstrated toxicity nanoparticles (ZnO-NPs) nanorods (ZnO-NRs). Recently, ZnO-NP has been shown to depend on...
Since the discovery of graphene, there has been a wide range literature dealing with its versatile structure and easy binding biomolecules as well large loading capacity. In emerging field immunotherapy, graphene derivatives have potential uses drug delivery platforms directly into tumour sites or adjuvants in cancer vaccines, they are internalized by monocytes which turn may activate adaptive anti-tumoral immune responses. this study, we expose cells innate system human acute monocytic...
Platelets are the major source of HMGB1, a protein that is involved in sterile inflammation blood vessels and thrombosis. Megakaryocytes synthesize HMGB1 transfer both mRNA into platelets platelet-derived microvesicles. Quantities free found supernatants vitro differentiated megakaryocytes megakaryoblastic cell line (DAMI cells). Aspirin "in vivo" vitro" not only reduces RAGE expression on platelets, but also drives movement from These findings suggest consumption low doses aspirin risk...
The in vitro biocompatibility of Graphene Oxide (GO) nanosheets, which were obtained by the electrochemical exfoliation graphite electrodes an electrolytic bath containing salts, was compared with pristine Single Wall Carbon Nanotubes (p-SWCNTs) under same experimental conditions different human cell lines. cells treated concentrations GO and SWCNTs for up to 48 h. did not induce any significant morphological or functional modifications (demonstrating a high biocompatibility), while SWNCTs...
Combined treatment of several natural polyphenols and chemotherapeutic agents is more effective comparing to the drug alone in inhibiting cancer cell growth. Polyphenolic artichoke extracts (AEs) have been shown anticancer properties by triggering apoptosis or reactive oxygen species- (ROS-) mediated senescence when used at high low doses, respectively. Our aim was explore chemosensitizing potential AEs order enhance efficacy conventional chemotherapy breast cells. We employed lines assess...
Thyroid cancer is the most common endocrine cancer, and its incidence increasing in many countries around world. Among thyroid cancers, papillary (PTC) histotype particularly prevalent. A small percentage of tumors associated with metastases aggressive behavior due to de-differentiation obtained through epithelial-mesenchymal transition (EMT) by which epithelial cells acquire a fibroblast-like morphology, reduce cellular adhesion, increase motility expression mesenchymal proteins. The tumor...
microRNA (miR/miRNA) are small non-coding RNAs that control gene expression at the post-transcriptional level by targeting mRNAs. Aberrant of miRNAs is often observed in different types cancer. Specific function as tumor suppressors or oncogenes and interfere with various aspects carcinogenesis, including differentiation, proliferation invasion. Upregulation 221 222 has been shown to induce a malignant phenotype numerous human cancers via inhibition phosphatase tensin homolog (PTEN)...
Heparin-induced thrombocytopenia (HIT) is a thrombotic complication of heparin therapy. The most used functional method for HIT diagnosis serotonin release assay (SRA). A different based on ATP with luciferin/luciferase long-life and stable luminescent signal here, which shown to be comparable accuracy SRA in both negative (patients 4Ts ≤3, anti-PF4/heparin immunoassay SRA) positive (4Ts >3, PF4/heparin antibodies patients.Our results show that higher washed platelets activated by sera from...
Abstract Objectives To investigate whether high mobility group box 1 (HMGB1) is involved in unexplained recurrent pregnancy loss (uRPL). Methods Plasma levels of HMGB1 were measured by ELISA non-pregnant women with (n=44) and without (n=53 controls) uRPL. Their platelets plasma-derived microvesicles (MVs) also assayed for HMGB1. Endometrial biopsies taken selected uRPL (n=5) control the tissue expression was determined western blot immunohistochemistry (IHC). Results plasma significantly...
Background. New antiviral textiles for the protection and prevention of life-threatening viral diseases are needed. Graphene oxide derivatives versatile substances that can be combined with fabrics by different green electrochemistry methods. Methods In this study, graphene (GO) nanosheets were textile samples to study GO potential. synthesized in Chemistry laboratories at University Rome Tor Vergata (Italy) characterized TEM/EDX, XRD, TGA, Raman spectroscopy, FTIR, was applied three...
Graphene oxide (GO) derivatives are reported as a valid alternative to conventional carriers of therapeutic agents, because they have large surface area, an excellent electrical and thermal conductivity great capacity for selective binding drugs therapeutics, due the functionalization their surfaces, edges sides. In this work GO nanosheets, synthesized by electrochemical exfoliation graphite (patent N 102015000023739, Tor Vergata University), were investigated possible anticancer drug, S29,...
Recent studies have shown that thyrocytes are permissive to HHV-6A infection and the virus may contribute pathogenesis of autoimmune thyroiditis. Thyroid diseases increase risk papillary cancer, which is not surprising considering chronic inflammation activates pathways also pro-oncogenic. Moreover, in this condition, cell proliferation stimulated as an attempt repair tissue damage caused by inflammatory process. Interestingly, it has been reported well-differentiated thyroid carcinoma...