A5103197818- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Sarcoma Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Anesthesia and Sedative Agents
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Venous Thromboembolism Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Shoulder and Clavicle Injuries
- Respiratory Support and Mechanisms
- Shoulder Injury and Treatment
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Bone health and treatments
- Non-Invasive Vital Sign Monitoring
- Musculoskeletal synovial abnormalities and treatments
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Endometrial and Cervical Cancer Treatments
- Blood Pressure and Hypertension Studies
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2000-2025
National Agency for New Technologies, Energy and Sustainable Economic Development
2020
Azienda Ospedaliera San Giovanni Addolorata
2019
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2019
University of Udine
2006-2018
Università Campus Bio-Medico
2015-2016
Carlo Forlanini Hospital
2016
Health First
2014
Ospedale Santa Maria della Misericordia di Udine
2006-2013
Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at present time. Here we describe early lung involvement by Covid-19 in a surgical sample resected for carcinoma from patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering macrophages, prominent and diffuse neutrophilic margination within septal vessels,...
Immune checkpoint inhibitors have revolutionized treatment and outcome of melanoma many other solid malignancies including non-small cell lung cancer (NSCLC) renal carcinoma (RCC). Unfortunately, only a minority patients long-term benefit, while the remaining demonstrate primary or acquired resistance. Recently, it has been demonstrated that prevalence programmed death-ligand 1 (PD-L1) tumor-infiltrating lymphocytes (TILs) varies based on anatomical site metastases. In particular, liver...
Objectives: To investigate the role of quantitative Magnetic Resonance Imaging (MRI) in preoperative assessment tumour aggressiveness patients with endometrial cancer, correlating multiple parameters obtained from diffusion and dynamic contrast-enhanced (DCE) MR sequences conventional histopathological prognostic factors inflammatory infiltrate. Methods: Forty-four biopsy-proven cancer underwent imaging at 3T scanner, including DCE imaging, diffusion-weighted (DWI) intravoxel incoherent...
The presence of epithelioid osteoblasts, lace- or sheet-like osteoid production, and a permeative pattern tumor growth in osteoblastomas is thought to be associated with an aggressive clinical behaviour. This study assessed the prognostic significance these other histologic parameters by analyzing large group cases. Histologic material obtained from 55 patients who had osteoblastoma diagnosed treated at Memorial Sloan-Kettering Cancer Center was analyzed. Additionally, radiographic images...
Platelet-derived growth factor (PDGF) plays a critical role in regulating the development and functional control of various tissues has been implicated pathogenesis serious diseases, including cancer atherosclerosis. Given emerging PDGF function male gonads, we compared expression profiles mRNAs A- B-chains receptor (PDGFR) α- β-subunits fetal adult human testis. The immunohistochemical localization corresponding proteins fetal, adult, diseased testicular was also analyzed. PDGFs PDGFRs were...
In Brief Study Design. Graded endplate injuries were performed in porcine lumbar discs. The effects of such compared to control animals which a sham operation was performed. Objectives. To investigate the on disc tissue. Summary Background Data. Studies have shown that vertebral endplates are frequently found at autopsy. However, little is known acute vivo. Methods. Ten domestic pigs included study group. Under general anesthesia, lower three discs spine exposed and randomly submitted...
<b><i>Objectives:</i></b> The aim of the study was to determine whether release by macrophages matrix metalloproteinase (MMP)-12 and vascular endothelial growth factor (VEGF) - leading inflammation, degradation neoangiogenesis represents an effective pathway that underlies aortic wall remodeling in Stanford type A acute dissection (AAD). <b><i>Methods:</i></b> Twenty-one consecutive patients with no genetic predisposition, AAD were selected. In...
High- and low-risk endometrial carcinoma (EC) differ in whether or not a lymphadenectomy is performed. We aimed to develop MRI-based radio-genomic models able preoperatively assess lymph-vascular space invasion (LVSI) discriminate between low- high-risk EC according the ESMO-ESGO-ESTRO 2020 guidelines, which include molecular risk classification proposed by “ProMisE”. This retrospective, multicentric study that included 64 women with who underwent 3T-MRI before hysterectomy. Radiomics...
Abstract Background Endometrial cancer (EC) is one of the most common gynecological malignancies and second malignancy cause death in women. Heterogeneous tissues with different grades complexity diffusion properties characterize EC. Several magnetic resonance imaging (DMRI) protocols have been used to perform a non‐invasive global evaluation EC for diagnostic prognostic purposes. However, association single value coefficient an tissue could be severe limit developing DMRI virtual histology...
Helper-dependent adenoviral vectors deleted of all viral coding sequences have shown an excellent gene expression profile in a variety animal models, as well reduced toxicity after systemic delivery. What is still unclear whether long-term and therapeutic dosages these can be obtained also the presence preexisting immunity to adenovirus, condition found high proportion adult human population. In this study we performed intramuscular delivery helper-dependent carrying mouse erythropoietin...