A5038020866- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Eosinophilic Disorders and Syndromes
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Ocular Oncology and Treatments
- Colorectal and Anal Carcinomas
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Parvovirus B19 Infection Studies
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Colorectal Cancer Treatments and Studies
- T-cell and Retrovirus Studies
- RNA Research and Splicing
- Sarcoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
University of Siena
2016-2025
Azienda Ospedaliera Universitaria Senese
2010-2025
Ospedale Santa Maria alle Scotte
2006-2020
University College London
2020
Charité - Universitätsmedizin Berlin
2005
Nairobi Hospital
1998-2005
Bicêtre Hospital
2005
Inserm
2005
Université Paris-Saclay
2005
University of Bologna
2003
Background: Anal HPV infection can cause squamous intraepithelial lesions (SILs), which are precursors of anal cell carcinoma (SCC). The early detection infections and improvement effective screening programmes are, therefore, essential to prevent progression from pre-cancerous SCC, especially in people living with HIV (PLWH), who represent a population at higher risk associated lesions. Among prevention strategies, vaccination is relevant too, but its efficacy persons already infected by...
The molecular feature of Burkitt lymphoma (BL) is the translocation that places c-Myc under control immunoglobulin gene regulatory elements. However, there accumulating evidence some cases may lack an identifiable MYC translocation. In addition, during EUROFISH project, aiming at standardization FISH procedures in diagnosis, we found five out 35 classic endemic BLs were negative for translocations by using a split-signal as well dual-fusion probe. Here investigated expression pattern miRNAs...
Endemic Burkitt lymphoma (eBL) is primarily found in children equatorial regions and represents the first historical example of a virus-associated human malignancy. Although Epstein-Barr virus (EBV) infection MYC translocations are hallmarks disease, it unclear whether other factors may contribute to its development. We performed RNA-Seq on 20 eBL cases from Uganda showed that mutational viral landscape more complex than previously reported. First, we presence herpesviridae family members 8...
Abstract Purpose: BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1–V600E) or dimers 2–codons 597/601), and RAS-dependent with impaired kinase activity 3–codons 594/596). Although clinical, pathologic, molecular features of V600EBRAF-mutated metastatic colorectal cancer (mCRC) well known, limited data available from the two other classes. Experimental Design: Data 117 patients (92 class 1, 12 2, 13 3)-mutated mCRC were collected. A total 540 wt mCRCs...
Background Recent evidence suggests that lipid pathway is altered in many human tumours. In Burkitt lymphoma this reflected by the presence of droplets which are visible cytoplasm neoplastic cells cytological preparations. These vacuoles not identifiable biopsy section as lipids “lost” during tissue processing. Methods and Results study we investigated expression genes involved metabolism, at both RNA protein level other B-cell aggressive cases. Gene profile indicated a significant...
Burkitt lymphoma is an aggressive B-cell presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic carry latent Epstein-Barr virus, whereas only 20% are associated with infection. Although the virus highly related form, how whether participates its pathogenesis remains to be fully elucidated. In particular, may impair cellular gene expression by own encoded microRNAs.Using microRNA profiling we compared Epstein-Barr-positive...
The Epstein–Barr virus (EBV) is linked to various B-cell lymphomas, including Burkitt lymphoma (BL), classical Hodgkin (cHL) and diffuse large (DLBCL) at frequencies ranging, by routine techniques, from 5 10% of cases in DLBCL >95% endemic BL. Using higher-sensitivity methods, we recently detected EBV traces a few EBV-negative BL cases, possibly suggesting “hit-and-run” mechanism. Here, used methods (qPCR ddPCR for conserved genomic regions miRNAs on microdissected tumor cells; EBNA1 mRNA In...
Hurthle cell adenomas and carcinomas, characterized by the presence of oncocytic cells, are unusual thyroid neoplasms, treatment which is still controversial. We analyzed specimens from 49 patients with nodular lesions including 20 adenomas, 19 10 hyperplasias for RET/PTC (papillary carcinoma) activation, most frequent genetic alteration in PTCs. activation was detected a significant number cases but 0 hyperplastic nodules. In particular, RET/PTC1 isoform found 7 12 4 carcinomas. These...
Endemic, sporadic and HIV-associated Burkitt lymphoma (BL) all have a B-cell phenotype MYC translocation, but variable association with the Epstein-Barr virus (EBV). However, there is still no satisfactory explanation of how EBV participates in pathogenesis BL. A recent investigation suggested that EBV-positive EBV-negative BL different cells origin. In particular, according to immunoglobulin gene mutation analysis, BLs may originate from early centroblasts, whereas seem arise postgerminal...
Summary Distinguishing Burkitt lymphoma (BL) from B cell lymphoma, unclassifiable with features intermediate between diffuse large B‐cell (DLBCL) and BL (DLBCL/BL), DLBCL is challenging. We propose an immunohistochemistry fluorescent in situ hybridization (FISH) based scoring system that employed three phases – Phase 1 (morphology CD10 BCL2 immunostains), 2 (CD38, CD44 Ki‐67 immunostains) 3 (FISH on paraffin sections for MYC , BCL6 immunoglobulin family genes). The was evaluated 252...
Epstein–Barr Virus (EBV) infects more than 90% of the adult population worldwide. EBV infection is associated with Burkitt lymphoma (BL) though alone not sufficient to induce carcinogenesis implying involvement co-factors. BL endemic in African regions faced mycotoxins exposure. Exposure and oncogenic viruses has been shown increase cancer risks partly through deregulation immune response. A recent transcriptome profiling B cells exposed aflatoxin B1 (AFB1) revealed an upregulation Chemokine...
ABSTRACT Mature aggressive B‐cell lymphomas, such as Burkitt lymphoma (BL) and Diffuse large (DLBCL), show variations in microRNA (miRNA) expression. The entity of High‐grade with 11q aberration (HGBCL‐11q) shares several biological features both BL DLBCL but data on its miRNA expression profile are yet scarce. Hence, this study aims to analyze the potential differences HGBCL‐11q compared DLBCL. We evaluated profiles 2083 miRNAs 25 HGCBL‐11q, 7 BL, 131 DLBCL, tonsils using HTG EdgeSeq whole...
The role of HPV in the carcinogenesis intraepithelial and invasive anogenital lesions is currently well established. E6 E7 oncoproteins high risk genotypes are known to inactivate p53 pRb pathways. Several studies have described an increased prevalence recurrence both cervical infection cancer among HIV-1 positive women compared negative cases. For these reasons, considered AIDS-defining neoplasm. Unlike other AIDS-associated neoplasms, occurrence independent immune suppression. patients...
Epstein-Barr virus (EBV) is a gammaherpesvirus linked to number of lymphoid and epithelial malignancies, including Burkitt lymphoma (BL) in which its frequency ranges from 30% sporadic cases 100% the endemic ones. The possible contribution EBV BL pathogenesis largely unknown. It has been suggested that may be associated with all cases, those diagnosed as negative by mechanism hit-and-run. Early during oncogenesis, viral genes are essential for initiating disease. Progressively, genome lost...
// Pier Paolo Piccaluga 1 , Mohsen Navari 1, 2 Giulia De Falco 2, 3 Maria Raffaella Ambrosio Stefano Lazzi Fabio Fuligni Cristiana Bellan Maura Rossi Rosaria Sapienza Antonella Laginestra Maryam Etebari Emily A. Rogena 4 Lynnette Tumwine 5 Claudio Tripodo 6 Davide Gibellini 7 Jessica Consiglio 8 Carlo M. Croce Pileri 9 Lorenzo Leoncini Hematopathology Section, Department of Experimental, Diagnostic, and Experimental Medicine, S. Orsola-Malpighi Hospital, Bologna University School Bologna,...