A5059897760- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Global Health and Surgery
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Immunotherapy and Immune Responses
- Advances in Oncology and Radiotherapy
- Chronic Lymphocytic Leukemia Research
- vaccines and immunoinformatics approaches
- Cancer Risks and Factors
- Clinical Laboratory Practices and Quality Control
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Chromatin Remodeling and Cancer
- Ethics in Clinical Research
- Breast Lesions and Carcinomas
Aga Khan University Nairobi
2016-2025
Aga Khan University Hospital Nairobi
2016-2025
Africa Center
2018-2024
Assiut University
2012-2022
Agricultural Genetic Engineering Research Institute
2022
University of Cape Town
2022
Menoufia University
2020
Kenyatta National Hospital
2018
Leidos (United States)
2017
Leidos Biomedical Research Inc. (United States)
2017
BackgroundPathology and laboratory medicine diagnostics diagnostic imaging are crucial to achieving universal health coverage. We analysed Service Provision Assessments (SPAs) from ten low-income middle-income countries benchmark availability.MethodsDiagnostic availabilities were determined for Bangladesh, Haiti, Malawi, Namibia, Nepal, Kenya, Rwanda, Senegal, Tanzania, Uganda, with multiple timepoints Tanzania. A smaller set of included in the analysis primary care facilities compared those...
To compare the most common diagnostic/laboratory tests across five different referral hospitals by volume and revenue.The authors obtained data on volumes reimbursement rates for 25 at with which they are affiliated organized them to be as comparable possible. Simple descriptive statistics were used make cross-country comparisons.There strong similarities all in top both revenue. However, differ from Reimbursement also follow patterns, being lowest biochemical test; intermediate hematology...
ObjectivesStudies on ER/PR/HER2 in breast cancer from Sub Saharan Africa (SSA) are fraught with inconsistencies the prevalence of hormone receptor status. In Kenya, for cancers is not part routine assessment and available only three to four centers across country. Variability methodology interpretation makes comparison between data difficult. Our aim was accurately determine using standardized techniques double reporting. Prognostic tumor parameters were also correlated clinical features...
Summary Distinguishing Burkitt lymphoma (BL) from B cell lymphoma, unclassifiable with features intermediate between diffuse large B‐cell (DLBCL) and BL (DLBCL/BL), DLBCL is challenging. We propose an immunohistochemistry fluorescent in situ hybridization (FISH) based scoring system that employed three phases – Phase 1 (morphology CD10 BCL2 immunostains), 2 (CD38, CD44 Ki‐67 immunostains) 3 (FISH on paraffin sections for MYC , BCL6 immunoglobulin family genes). The was evaluated 252...
Data on breast healthcare knowledge, perceptions and practice among women in rural Kenya is limited. Furthermore, the role of male head household influencing a woman's health seeking behavior also not known. The aim this study was to assess cancer women, heads households, opinion leaders providers within community Kenya. Our secondary objective explore households behavior. This mixed method cross-sectional study, conducted between Sept 1st 2015 30th 2016. We administered surveys households....
: Triple-negative breast cancer (TNBC) patients of various ethnic groups often have discrete clinical presentations and outcomes. Women African descent a disproportionately higher chance developing TNBCs. The aim the current study was to establish transcriptome TNBCs from Kenyan (KE) women Bantu origin compare it those African-Americans (AA) Caucasians (CA) for identifying KE TNBC-specific molecular determinants progression potential biomarkers Pathology-confirmed TNBC tissues (n = 15) age...
Abstract Women of African descent have the highest breast cancer mortality in United States and are more likely than women from other population groups to develop an aggressive disease. It remains uncertain what extent Africa is reminiscent American or European patients. Here, we performed whole-exome sequencing genomic DNA 191 tumor non-cancerous adjacent tissue pairs obtained 97 American, 69 2 Asian 23 Kenyan Our analysis data revealed elevated mutational burden both patients, when...
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies. However, its application in solid tumors remains limited because single targets are unlikely to suffice due tumor heterogeneity and off-tumor toxicities. To overcome these obstacles, we developed LogiCAR designer, a computational approach that utilizes single-cell transcriptomics data from patient systematically identify cancer-specific circuits with logic gates ("AND," "OR," "NOT")...
Abstract Background: Tumor-infiltrating immune cells in the tumor microenvironment (TME) are critical for breast cancer (BC) progression and treatment outcomes, with notable variations observed across populations. Unique BC risk factors, such as germline genetics, mammographic density, infectious exposures, lifestyle may shape distinctive profiles lead to distinct characteristics clinical outcomes different Comparing cell compositions populations can improve our understanding of racial...