A5047962328- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Eosinophilic Disorders and Syndromes
- HIV Research and Treatment
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- T-cell and Retrovirus Studies
- Histiocytic Disorders and Treatments
- NF-κB Signaling Pathways
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Mast cells and histamine
- Galectins and Cancer Biology
- Immune Response and Inflammation
- Urticaria and Related Conditions
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Acute Myeloid Leukemia Research
Université Paris-Sud
2009-2021
Bicêtre Hospital
2008-2019
Queen Elizabeth Hospital Birmingham
2016-2018
Institut Gustave Roussy
1999-2017
Centre National de la Recherche Scientifique
1986-2017
Université Paris-Saclay
2005-2017
Assistance Publique – Hôpitaux de Paris
2007-2016
Inserm
2001-2016
Université Paris Cité
1997-2015
Janssen (Belgium)
2015
One hundred and twenty-nine patients with chronic lymphocytic leukemia (CLL) followed in our outpatient department for periods ranging from 6 months to 13 years were divided into five anatomico-clinical stages: stage O (peripheral bone marrow lymphocytosis); I (stage + lymph node enlargement); II palpable spleen); III II); IV (anemia or thrombocytopenia). Analysis of actuarial survival curves revealed the following: 1) median entire population exceeded 114 months; 2) there was no difference...
PURPOSE Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as result immunosuppressive therapy. Most B-cell lymphomas associated with Epstein-Barr virus (EBV) infection. We describe morphologically and clinically distinct group PTLD in 11 patients that occurred late after organ transplantation were not EBV. PATIENTS AND METHODS There seven kidney, three heart, one liver transplant (group I). The clinical manifestations, pathologic findings, treatment,...
To describe, in a retrospective study, the clinical and pathological spectrum of multicentric Castleman's disease (MCD) HIV infection.The diagnosis MCD was established by lymph node biopsy 20 HIV-infected patients. All patients had been sexual contact. At diagnosis, infection asymptomatic eight Kaposi's sarcoma present 12. Mean +/- SD CD4+ cell count 156 99 x 10(6)/l.Patients were referred with syndrome fever splenomegaly (100%), peripheral lymphadenopathy (90%), hepatomegaly (70%), severe...
ABSTRACT The transcription factor family NF-κB/Rel is responsible for the regulation of a large number cellular genes and some viruses. Since there strong similarity between members Drosophila melanogaster protein DORSAL, which activated early during embryogenesis, we were interested in determining pattern NF-κB activity mouse development. Two lacZ reporter constructs, each driven by promoter elements that are dependent on presence nuclear activity, used to produce transgenic mice. analysis...
PURPOSE: Prognostic studies of posttransplantation lymphoproliferative disorders (PTLDs) are hindered by the small number cases at each transplant center. We analyzed prognostic factors and long-term outcome according to clinical manifestations, pathologic features, treatment investigated value non-Hodgkin’s lymphoma International Index (IPI) in 61 patients with PTLD. PATIENTS AND METHODS: studied two institutions who developed PTLD influencing complete remission survival rates. RESULTS: In...
To evaluate the safety and efficacy of rituximab adjunction to cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) regimen in patients with newly diagnosed AIDS-related non-Hodgkin's lymphoma.HIV-seropositive high-grade lymphoma B-cell origin were eligible if they had no more than one following characteristics: CD4 cell count less 100/microL, prior AIDS, or performance status 2. This multicenter phase II trial evaluated response rate disease-free survival after six courses plus...
Adolescents (age 15 to 21 years) compared with younger children mature B-cell non-Hodgkin's lymphoma (NHL) have been historically considered an inferior prognosis. We therefore analyzed the impact of age and other diagnostic factors on risk treatment failure in adolescents treated French-American-British Mature B-Cell Lymphoma 96 (FAB LMB 96) trial.Patients were divided by risk: group A (limited), B (intermediate), C (advanced), as previously described. Prognostic for event-free survival...
We reviewed 72 primary central nervous system lymphomas occurring in immunocompetent patients. The cases were for clinical data, histology, immunophenotype, bcl-2 and p53 expression, Epstein-Barr virus association. Follow-up was available 40 patients included the Groupe Ouest Est d'étude des Leucénies et Autres Maladies du Sang (GOELAMS) lymphomes cérébraux primitifs (LCP 88) trial. Each diagnosis, requiring a consensus among at least 3 pathologists, performed according to recent Revised...
Summary. Systemic mastocytosis (SM) is characterized by proliferation of mast cells in various organs, which may release a wide variety mediators, thereby explaining the broad clinical spectrum disease manifestations. The potentially life‐threatening systemic symptoms and tumoral are poorly controlled despite use several cytotoxic chemotherapies and/or symptomatic treatments. Twenty consecutive adult SM patients with histologically confirmed bone marrow (BM) involvement received interferon‐α...