A5062090981- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders
- Immune cells in cancer
- Gastroesophageal reflux and treatments
- Hidradenitis Suppurativa and Treatments
- Autoimmune Bullous Skin Diseases
- Hedgehog Signaling Pathway Studies
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Connective tissue disorders research
- TGF-β signaling in diseases
- Growth Hormone and Insulin-like Growth Factors
- Parvovirus B19 Infection Studies
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Breast Lesions and Carcinomas
- Dermatological and Skeletal Disorders
- Digestive system and related health
- Chronic Lymphocytic Leukemia Research
- T-cell and Retrovirus Studies
- Skin Diseases and Diabetes
University of Siena
2015-2025
Azienda Ospedaliera Universitaria Senese
2025
Ospedale Santa Maria alle Scotte
2015-2022
Center for Rheumatology
2022
University of Parma
2013-2014
Queen Fabiola Children's University Hospital
2006
Istituto di Sessuologia Clinica
1996
Ospedali Riuniti di Ancona
1996
Ospedale Generale Regionale Francesco Miulli
1991
Background: Anal HPV infection can cause squamous intraepithelial lesions (SILs), which are precursors of anal cell carcinoma (SCC). The early detection infections and improvement effective screening programmes are, therefore, essential to prevent progression from pre-cancerous SCC, especially in people living with HIV (PLWH), who represent a population at higher risk associated lesions. Among prevention strategies, vaccination is relevant too, but its efficacy persons already infected by...
The Epstein–Barr virus (EBV) is linked to various B-cell lymphomas, including Burkitt lymphoma (BL), classical Hodgkin (cHL) and diffuse large (DLBCL) at frequencies ranging, by routine techniques, from 5 10% of cases in DLBCL >95% endemic BL. Using higher-sensitivity methods, we recently detected EBV traces a few EBV-negative BL cases, possibly suggesting “hit-and-run” mechanism. Here, used methods (qPCR ddPCR for conserved genomic regions miRNAs on microdissected tumor cells; EBNA1 mRNA In...
Thyroid cancer (TC) is the most common endocrine malignancy, and its incidence continues to rise worldwide [...]
Abstract Background The Tumor Microenviroment (TME) is a complex milieu that increasingly recognized as key factor in multiple stages of disease progression and responses to therapy well escape from immune surveillance. However, the precise contribution specific effector suppressor components TME Burkitt lymphoma (BL) remains poorly understood. Methods In this paper, we applied computational algorithm CIBERSORT Gene Expression Profiling (GEP) datasets 40 BL samples draw map stromal TME....
Abstract MYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN MYCL . Recently, while assessing degree correlation between gene rearrangement protein expression aggressive B-cell lymphomas, we observed few Burkitt lymphoma (BL) cases lacking despite translocation involving gene. Therefore, present study aimed better characterize such cases. Our results identified two sub-groups negative BL: one detectable but presenting mRNA expression;...
Burkitt lymphoma (BL) is an aggressive B-cell that, in some instances, may show a granulomatous reaction associated with favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define tumour microenvironment (TME) four such cases, two of which regressed spontaneously.
Hereditary Breast and Ovarian Cancer (HBOC) syndrome is a condition in which the risk of breast ovarian cancer higher than general population. The prevalent pathogenesis attributable to inactivating variants
The incidence of thyroid cancer (TC) in Italy is one the highest Europe, and reason for this unclear. intra-country heterogeneity TC suggests possibility an overdiagnosis phenomenon, although environmental factors cannot be excluded. aim our study to evaluate trend southern Tuscany, Italy, area with particular geological characteristics, where pollution subsequent deterioration various matrices potentially toxic elements (heavy metals) introduced from either or anthropogenic (human...
The aim of this work was to correlate color duplex sonography (CDS) patterns and thyroid histology in hyperthyroid Graves' disease (GD) patients. Sixteen patients with relapsed GD were studied. Before starting a new cycle medical therapy methimazole decreasing doses for 3 6 months (baseline study), the underwent functional, autoimmune, CDS studies. same studies carried out again just before surgery (presurgical study) after had produced normalization hormone serum levels. glands...
The diagnostic corroboration of the relationship between gastro-oesophageal reflux disease (GERD) and chronic cough remains challenging.To compare oesophageal mucosal intercellular space diameter (ISD) in children with GERD, (GER)-related (GrC) a control group, to explore baseline impedance levels dilated ISD GER-related cough.Forty 15 GrC 12 controls prospectively underwent oesophagogastroduodenoscopy (EGD) biopsies taken 2-3 cm above squamocolumnar junction. were quantified using...
BACKGROUND: UVA1 phototherapy is a valid therapeutic alternative for skin lymphoproliferative disorders, although there are few studies concerning its role in mycosis fungoides (MF). Our aim was to evaluate and confirm the effectiveness of patients early stage MF.METHODS: We enrolled 12 patients, 9 males 3 females (mean age 54.83±9.99, range 36-74) with histological diagnosis at stage. All were treated 22 sessions two different protocols (3 times or 5 per week) dose 45 J/cm2. A punch biopsy...
Morosini PP, Taccaliti A, Arnaldi G, Simonella Petrelli MD, Mancini V, Montironi R, Scarpelli M. Diamanti L, Mantero F. Enhanced expression of transforming growth factor β 1 in rat thyroid hyperplasia is thyrotropin induced and time dependent. Eur J Endocrinol 1996:134:373–8. ISSN 0804–4643 Forty-three 8-week-old male Wistar rats were studied to evaluate temporal changes TGF-β ) mRNA levels tissue during pharmacologically goiter. Four treated with purified bovine (TSH; Ambinon, 2 mU/day sc)...
The aim of this work was to establish whether the immunohistochemical pattern for TGF-β1 in goiters that recur after thyroid surgery is different when compared with do not postoperatively. Twelve goiters, surgically removed by partial resection between 1977 and 1982, were studied. Ten years surgery, 6 patients had recurrence goiter or nodules (group 1); others did have any 2). presence location evaluated a posteriori immunohistochemistry histological samples tissue removed. In each specimen,...
Psoriasis (PSO) is traditionally defined as an immune-mediated, inflammatory dermatological disease characterized by a chronic-relapsing course and associated with multifactorial inheritance (genetic predisposition influence of various environmental factors). Considered until recently only, today PSO correctly known systemic one because the involvement multiple organs important impact on social life relationships. found in 0.3-4.6% world's population, while its prevalence Italian population...
Abstract The precise B cell of origin and molecular pathogenesis nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity NMZL, vast majority already-published studies have been conducted on a limited number samples technical approach analyze immunoglobulin genes was amplifying rearranged variable region with classical direct sequencing PCR products followed by cloning. Here, we studied Ig heavy-chain repertoires next-generation (NGS) in 30 NMZL cases. Most cases...