A5037915468- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Hematopoietic Stem Cell Transplantation
- Nail Diseases and Treatments
- Skin and Cellular Biology Research
- Antifungal resistance and susceptibility
- Asthma and respiratory diseases
- Eicosanoids and Hypertension Pharmacology
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Hedgehog Signaling Pathway Studies
- Spondyloarthritis Studies and Treatments
- Immune Response and Inflammation
- Genetic and rare skin diseases.
- Corneal Surgery and Treatments
- melanin and skin pigmentation
- T-cell and B-cell Immunology
- Proteoglycans and glycosaminoglycans research
- Drug-Induced Adverse Reactions
- Skin Protection and Aging
- Lymphatic System and Diseases
- Histiocytic Disorders and Treatments
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
Ospedale San Donato
2019-2024
University of Siena
2003-2008
Institute of Dermatology
2003
Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by recurrent episodes of flares. Characteristics patients experiencing flare are hardly described in real-life setting. The aim the study to investigate clinical characteristics GPP.Multicenter retrospective observational on consecutive GPP between 2018 and 2022. Disease severity quality life were assessed Pustular Psoriasis Area, Body Surface Area (BSA), Severity Index (GPPASI), Dermatology index...
Purpose Tildrakizumab is a selective inhibitor of IL-23 approved for the treatment moderate-to-severe plaque psoriasis in two dosages. We conducted 16-week multicenter retrospective study to compare effectiveness and safety tildrakizumab 200 mg versus 100 patients with high disease burden or body weight.
Tildrakizumab (TIL) is an interleukin (IL)-23p19 inhibitor for the treatment of moderate-to-severe plaque psoriasis with long-term efficacy and safety demonstrated in Phase III trials. Studies conducted conditions closer to clinical practice are needed.The TRIBUTE study (open-label, IV) assessed impact on health-related quality life (HRQoL) TIL 100 mg adult patients (naïve IL-23/Th17 pathway inhibitors) similar practice.Key measure was Psoriasis Area Severity Index (PASI). HRQoL evaluated...
Summary Recent studies suggest that extracorporeal photochemotherapy (ECP) may be beneficial in patients with steroid‐refractory chronic graft‐ versus ‐host disease (cGvHD). However, it is not yet clear whether certain conditions, such as age, mode of onset cGvHD etc., influence clinical response and affected organs are more sensitive to ECP than others. We analysed the main laboratory parameters related evolution 32 patients, identify any useful predictors ECP. course positively 78% (25/32)...
The aim of this multicenter observational study is to report data from real world on the use bimekizumab in patients aged ≥ 65 years with moderate-to-severe plaque psoriasis. Elderly are poorly represented clinical trials for psoriasis, and real-world studies important guide choices.
Psoriatic disease is associated with considerable impairment of quality life (QoL). The PROSE study (NCT02752776) investigated the impact secukinumab treatment on patient-reported outcomes (PRO) in patients moderate to severe psoriasis stratified by their history.PROSE was a prospective, non-randomised, multicentre study. Patients were categorized at baseline according history as naïve [naïve any systemic therapy (N = 663)], conventional [previously exposed ≥1 (CS) 673)] and biologics...
A nationwide survey was conducted in adult patients with psoriasis (PsO) across Italy to obtain their real-world perspective of the impact PsO on wellbeing. Patients completed a 26-question (based patient benefit index; PBI, The Dermatology Life Quality Index; DLQI and World Health Organization-five; WHO-5 wellbeing index) workshop discussion sessions were undertaken by dermatologists interpret results from survey. 392 Analysis restricted who had moderate-to-severe plaque (assessed patients;...
Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic bone marrow transplantation. Extracorporeal photopheresis (ECP) has recently been introduced as an alternative treatment for cases cGVHD refractory to conventional immunosuppressive treatment, but its mechanism action not yet clear.To investigate in seven patients with the effects ECP on resistance monocytes apoptosis and monocyte cytokine production.We designed vitro model that could mimic potential vivo effect...
Atopic dermatitis (AD) is an inflammatory disease with a chronic-relapsing course that intensely itchy. A correct diagnosis of AD in adults and consequently appropriate clinical therapeutic management critical issue for extreme expression heterogeneity various grades severity. In order to ensure high levels care standardization Adult AD, the decision was taken create Tuscan Consensus Group (the Group), work on validate consensus based regional clinical-therapeutic model. The aims were find...
(1) Background/Objectives: Nail psoriasis (NP) is a chronic and difficult-to-treat disease, which causes significant social stigma impairs the patients' quality of life. Moreover, nail true therapeutic challenge for clinicians. The presence can be part severe form have predictive value development psoriatic arthritis. Our real-world-evidence multicenter study aims to evaluate efficacy bimekizumab in psoriasis. (2) Methods: A retrospective analysis observational included 834 patients affected...
Background Cyclosporine A (CsA) is one of the systemic therapeutic options for moderate-to-severe psoriasis, based on its efficacy and rapidity action. The current study investigated response to CsA in patients with plaque psoriasis.Materials Methods TRANSITION was an observational, cross-sectional, multicentre which evaluated proportion partial- suboptimal-responders among psoriasis treated continuous ≥12 weeks. Patients demonstrating a Psoriasis Area Severity Index (PASI) ≥90, ≥75 <90, ≥50...
Psoriasis is a common chronic skin disease characterized by worldwide distribution and natural tendency towards progression. According to the many clinical forms, extension of comorbidities, almost 20% patients require systemic treatment. Biologics have greatly changed ongoing psoriasis quality life patients. After anti-TNF-alpha, which were first biologics in use for psoriasis, improvement knowledge pathogenetic mechanisms underlying has led development series more specific therapies...
Digital microscopy is a non-invasive diagnostic technique enabling determination of characteristics that cannot be appreciated by direct observation. If correctly applied, this can useful for the diagnosis pigmented skin lesions.To evaluate utility digital analysing atypical benign and malignant lesions exploiting numerical filtering automatic measurements.Forty-eight parameters were identified as possible discriminating variables, grouped in four categories: geometries, colours, textures,...
Psoriasis (PSO) is traditionally defined as an immune-mediated, inflammatory dermatological disease characterized by a chronic-relapsing course and associated with multifactorial inheritance (genetic predisposition influence of various environmental factors). Considered until recently only, today PSO correctly known systemic one because the involvement multiple organs important impact on social life relationships. found in 0.3-4.6% world's population, while its prevalence Italian population...
The number of psoriatic elderly patients is steadily increasing in the Western world, nevertheless they are frequently excluded from clinical trials and described as a high-risk group for adverse events.We conducted retrospective multicentric study DMF use (>65 years) patients. efficacy was evaluated up to 24 weeks by Psoriasis Area Severity Index (PASI) score. We also drug maintenance safety.Our population included 81 treated with weeks. PASI score at baseline (week 0) ranged 3,7-24 (mean ±...
BACKGROUND: Psoriasis (PsO) is a common immune mediated inflammatory disease, affecting about 60 million people worldwide. Although current therapies have dramatically changed the therapeutic approach to heterogeneity of responses often results in an essential unmet clinical need. This study describes design and development Registry (Pso-Reg), Italian electronic-based-registry, aimed collect real life data patients with psoriasis.METHODS: Pso-Reg multicenter, retrospective observational...
We evaluated a 11-year-old male patient with mental delay, autism and brownish whitish skin spots. The former resembled those of neurofibromatosis, the latter tuberous sclerosis. received complete clinical work-up to exclude sclerosis, or any other known neurocutaneous disease, biochemistry, chromosome analysis specimens. Being all tests not significant, two main ultrastructural defects were observed. first was blockage in intracellular vescicular trafficking sparing mitochondria; second an...
Abstract: We report a 6‐year‐old girl with subtle form of hypohidrotic ectodermal dysplasia and phenotype consisting curly hair, round face, stocky build, obesity, which was associated intrathoracic neuroblastoma. Although this new association could be chance occurrence, its description may alert physicians to look for similar combinations these, as it lead better syndrome delineation, patient care.