A5014385558- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Acne and Rosacea Treatments and Effects
- Immunodeficiency and Autoimmune Disorders
- melanin and skin pigmentation
- Wound Healing and Treatments
- Hidradenitis Suppurativa and Treatments
- Skin Protection and Aging
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders
- Diagnosis and Treatment of Venous Diseases
- Retinoids in leukemia and cellular processes
- Contact Dermatitis and Allergies
- Oral Health Pathology and Treatment
- Inflammatory Bowel Disease
- Skin Diseases and Diabetes
- Vascular Tumors and Angiosarcomas
- Hepatitis C virus research
- Surgical Sutures and Adhesives
- Pressure Ulcer Prevention and Management
- Nail Diseases and Treatments
- Textile materials and evaluations
- Nonmelanoma Skin Cancer Studies
- Cytokine Signaling Pathways and Interactions
University of Pisa
2016-2025
Weatherford College
2024
Marymount University
2024
Azienda Ospedaliera Universitaria Pisana
2019
Objective: This European, multicentric, retrospective study aimed to collect data on secukinumab effectiveness in a real-world setting.Research design and methods: All psoriatic patients starting between January 2016 February 2017 11 European centers were followed until 2018 retrospectively evaluated.Main outcome measures: Secukinumab was assessed by relative improvement from baseline of the Psoriasis Area Severity Index (PASI) absolute PASI score modifications throughout 52 weeks therapy....
Abstract Background There is a strong interaction between the immunological and nervous system in skin. Lesions that are physically disfiguring chronically relapsing have high impact on quality of life (QoL) can result emergence psychiatric disorders. The literature data confirm higher prevalence disorders patients with psoriasis, hidradenitis suppurativa (HS) atopic dermatitis (AD), but such compromised by low‐quality evidence due to methodological heterogeneity. Objectives primary aim was...
ABSTRACT Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that challenging to diagnose and treat. Clinicians frequently use fast-acting corticosteroids, which are subsequently combined with slower-acting immunosuppressants progressively taper the corticosteroid dosage. Current research focused on of monoclonal antibodies (mAbs) directed against target molecules involved in pathogenesis PG. However, available data their efficacy based sporadic case reports clinical experiences, so...
Our study aimed to investigate the correlation between skin cancer and anti-interleukin (IL) therapy in patients with moderate-to-severe psoriasis. This was an observational monocentric which we enrolled a total of 235 127 were affected by psoriasis treated anti-IL monoclonal antibodies (mAbs) for at least 6 months, whereas 108 mild topical therapies. Afterward, performed dermatologic visit all subjects, collecting anamnestic information including risk factors cancer. We examined lesions on...
Background The aim of this study is to confront the effectiveness anti-IL 17 versus 23 mAb in treating palmoplantar psoriasis by comparing incidence patients that required a therapy switch another class. Furthermore, we calculated mean time intercurrent beginning with mAbs and necessity class due ineffectiveness.
Acitretin is one of the systemic agents used for treatment psoriasis. Because different acitretin dosages resulted therapeutically successful, there no general agreement on optimal dose regimen. To report efficacy and safety in a real-life setting, wherein patient-tailored regimen usually prescribed, retrospective analysis evaluating charts all plaque-type psoriasis patients treated with from clinic database was performed. PASI score improvement, as well 50, 75, 90, 100 responses were...
Abstract Background High‐frequency ultrasound (HFUS) is a non‐invasive method that detects superficial skin features. Ultra‐high frequencies (50‐100 MHz) can reveal epidermis and dermis structures. Objectives In this study, we describe the psoriatic plaque using new device equipped with 70 MHz probe (VEVO ® MD, Fujifilm, VisualSonics) assess lesion before after ixekizumab. Methods We examined hyperechoic band, subepidermal hypoechoic band (SLEB), vascularization of in ten patients affected...
Psoriasis is a chronic and relapsing inflammatory skin disease, clinically characterized by erythematous scaly plaques. Treatment approach mainly driven disease severity, though several factors should be considered in order to identify the optimal therapeutic choice. Mild psoriasis may treated with wide array of topical agents including corticosteroids, vitamin D analogs, keratolytics, calcipotriol/betamethasone propionate compound. Because guidelines not provide practical indications...
Objective: The effects of a collagen dressing on hard-to-heal venous leg ulcers (vlUs) were evaluated in this prospective, randomised, controlled study. Method: Patients with vlU included and divided into two groups using the block randomisation method. first group was treated an alginate (group A), second alone b). both also had short-stretch compression system applied at every change. dressings changed twice week for 12 weeks or until ulcer healed. Granulation tissue improvement, wound...
Psoriasis is a skin disorder characterized by chronic inflammation driven different immunologic pathways, among which the IL-23/Th17 axis plays pivotal role. For this reason, use of IL23p19 inhibitors in psoriasis treatment has been evaluated over years. Guselkumab, totally human IgG1 lambda monoclonal antibody, that selectively blocks p 19 subunit IL- 23 demonstrated high efficacy and safety throughout several, randomized, double-blind phase III trials (VOYAGE 1 2, NAVIGATE ECLIPSE). We...
Abstract Vitiligo is a multifactorial acquired dermatosis characterised by achromic or hypochromic macules and the absence of functioning melanocytes. Treatment depends on extent affected areas disease activity. Surgical techniques have proven to be effective in stable cases but can time‐consuming and, some cases, aesthetically unsatisfying painful for patients. The aim study was assess clinical safety effectiveness new automatic epidermal skin harvesting device patients with localised...
Abstract: This study was carried out to assess the efficacy and tolerability of topical application an aqueous extract Triticum vulgare (TV) in different vehicles (cream, impregnated gauzes, foam, hydrogel, dressing gel) for treatment venous lower leg ulcers. Fifty patients were randomized receive one five investigational vehicles. Treatment performed up complete healing or a maximum 29 days. The wound size reduction from baseline primary variable, which measured by means noninvasive laser...
Abstract: Acne fulminans (AF) is a rare acne variant characterized by sudden onset of painful nodules on the face, chest, and back in presence systemic symptoms. Pharmacologic agents such as steroid hormones isotretinoin are well-known triggers, several cases have been described. We report case AF occurring few days after lymecycline therapy initiation. Keywords: onset, symptoms, steroids, trigger, isotretinoin, scars
Psoriatic onychopathy is one of the clinical presentations psoriasis and a well-known risk factor for development psoriatic arthritis. High-frequency ultrasounds (HFUS > 20 MHz) have recently been used to evaluate nail apparatus healthy subjects. The aim our study was detect by means ultra-high-frequency ultrasound (UHFUS 70-100 alterations bed matrix in patients with monitor these parameters during treatment monoclonal antibody (mAb). We enrolled 10 naive previous biologic therapies....
Background: Switching between biologics is commonly performed for the management of plaque psoriasis. However, no evidence about switching from secukinumab to ustekinumab has been reported. Methods: This retrospective observational multicenter study aimed describe efficacy and safety in nonresponder patients. Results: A total 21 patients unresponsive were treated with a mean period 53.3 weeks. Ustekinumab was effective reducing disease severity, significant improvements both psoriasis area...
Psoriasis is a common chronic skin disease characterized by worldwide distribution and natural tendency towards progression. According to the many clinical forms, extension of comorbidities, almost 20% patients require systemic treatment. Biologics have greatly changed ongoing psoriasis quality life patients. After anti-TNF-alpha, which were first biologics in use for psoriasis, improvement knowledge pathogenetic mechanisms underlying has led development series more specific therapies...
Psoriasis (PSO) is traditionally defined as an immune-mediated, inflammatory dermatological disease characterized by a chronic-relapsing course and associated with multifactorial inheritance (genetic predisposition influence of various environmental factors). Considered until recently only, today PSO correctly known systemic one because the involvement multiple organs important impact on social life relationships. found in 0.3-4.6% world's population, while its prevalence Italian population...