A5047492234- Ion channel regulation and function
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pharmacogenetics and Drug Metabolism
- Thyroid and Parathyroid Surgery
- Adrenal and Paraganglionic Tumors
- Cardiac Ischemia and Reperfusion
- Cancer, Hypoxia, and Metabolism
- Head and Neck Anomalies
- Toxic Organic Pollutants Impact
- Takotsubo Cardiomyopathy and Associated Phenomena
- Vitamin D Research Studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Chemical Analysis and Environmental Impact
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Vitamin K Research Studies
- Linguistics and Language Studies
- Nitric Oxide and Endothelin Effects
- COVID-19 Clinical Research Studies
- Bone health and treatments
Nuovo Ospedale di Prato
2023
University of Pisa
2007-2019
Ospedale Cisanello
2014-2016
University of Insubria
2014
Istituto di Fisiologia Clinica
2014
National Research Council
2014
Patients with amiodarone-induced thyrotoxicosis (AIT) and left ventricular (LV) systolic dysfunction have a high mortality rate. Usually, medical therapy is the first choice for AIT patients, whereas role of thyroidectomy unsettled. The objective study was to evaluate effect total on cardiac function survival patients severe LV dysfunction. This retrospective cohort study. conducted at tertiary university center. All (n = 24; nine type 1 AIT, 15 2 AIT) referred Department Endocrinology...
Considering the different pathogenic mechanisms of two main forms amiodarone-induced thyrotoxicosis (AIT), we ascertained whether this results in a onset time as well.We retrospectively analyzed clinical records 200 consecutive AIT patients (157 men and 43 women; mean age 62.2±12.6 years) referred to our Department from 1987 2012. The was defined elapsed beginning amiodarone therapy first diagnosis thyrotoxicosis, expressed months. Factors associated with were evaluated by univariate...
It is not known whether total thyroidectomy more favorable than medical therapy for patients with amiodarone-induced thyrotoxicosis (AIT).To compare on survival and cardiac function in AIT patients.Observational longitudinal cohort study involving 207 that had received (surgery group, n = 51) or (medical 156) over a 20-year period. types left ventricular ejection fraction (LVEF) classes were determined at diagnosis of AIT. Cardiac thyroid reevaluated during the Survival was estimated using...
Context: Amiodarone-induced thyrotoxicosis (AIT) resulting from destructive thyroiditis (type 2) is commonly treated with glucocorticoids, but time needed to restore euthyroidism may be unacceptable for patients underlying cardiac disorders.
Summary Context Two main forms of amiodarone‐induced thyrotoxicosis (AIT) exist. Type 1 AIT is a form iodine‐induced hyperthyroidism. Its management complex and includes thionamides, potassium perchlorate and, occasionally, thyroidectomy. 2 destructive thyroiditis, responds to glucocorticoids, usually does not require further thyroid treatment once euthyroidism has been restored. Objective To assess retrospectively the prevalence relative proportion type over 27‐year period at tertiary...
Context: Type 2 amiodarone-induced thyrotoxicosis (AIT) is a destructive thyroiditis usually responsive to glucocorticoids; however, recent surveys showed that many expert thyroidologists worldwide use thionamides for type AIT patients. Objective: The objective of the study was compare effectiveness methimazole (MMI) or prednisone (GLU) in patients who had short cure time according published predictive model. Design: This matched retrospective cohort study. Setting: conducted at university...
Type 2 amiodarone-induced thyrotoxicosis (AIT) is a destructive thyroiditis usually responsive to glucocorticoids. Whether continuation of amiodarone affects treatment outcome unsettled.The objective the study was compare glucocorticoid in type AIT patients who continued or withdrew amiodarone.This matched retrospective cohort study.The conducted at university center.Eighty-three consecutive with untreated participated study. After matching continuing (AMIO-ON, n = 8), interrupting were...
Thyroid cancer (TC) is the most common endocrine malignancy, and its incidence continues to rise worldwide [...]
Objective The primary objective of this study is to identify the predictors comorbidities and major adverse cardiovascular events (MACE) that can develop after diagnosis acromegaly. role therapy for acromegaly in event such complications was also evaluated. Design methods Retrospective cohort conducted on 200 consecutive acromegalic patients a tertiary referral center. following outcomes were evaluated: diabetes, hypertension MACE. Each patient included analysis specific outcome, unless they...
Polychlorinated biphenyls (PCBs) can disrupt the endocrine function, promote neoplasms and regulate apoptosis in some tissues; however, it is unknown whether PCBs affect of pituitary cells. The study evaluated effect on normal cells underlying mechanisms. Primary cell cultures obtained from mouse glands were exposed to Aroclor 1254 or selected dioxin-like (PCB 77, PCB 126) non-dioxin-like 153, 180) congeners. Apoptosis was by Annexin V staining, DNA fragmentation, TUNEL assay. Both...
Background: Thyrotropin (TSH)–secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone (RTH) are two forms of inappropriate TSH secretion. Thyroid blood flow is largely dependent. Objective: To assess whether may help differentiate TSHoma RTH. Design: Intrathyroidal color Doppler sonography (CFDS) pattern peak systolic velocity (PSV) were assessed at baseline during T3 suppression test on eight consecutive patients with 10 Main outcome: All controls had CFDS 0. Three RTH I...
Minimally invasive video-assisted thyroidectomy (MIVAT) proved to be safe and effective in the treatment of both benign malignant disease. The aim present study is compare MIVAT approach with conventional for total a group 99 pediatric patients operated Department General Surgery University Pisa between March 2007 July 2012.A under age 18 years thyroid disease referred our undergo thyroidectomy. Patients were divided into two groups according surgical technique performed: 34/99 (34.3%)...
The use of antivirals, corticosteroids, and IL-6 inhibitors has been recommended by the WHO to treat COVID-19. CP also considered for severe critical cases. Clinical trials on have shown contradictory results, but an increasing number patients, including immunocompromised ones, benefits from this treatment. We reported two clinical cases patients with prolonged COVID-19 infection B-cell depletion who showed rapid virological recovery after administration CP. first patient in study was a...