A5002934141- HIV Research and Treatment
- Malaria Research and Control
- Mosquito-borne diseases and control
- Extracellular vesicles in disease
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Pulmonary Hypertension Research and Treatments
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- Neonatal Respiratory Health Research
- Parasitic Infections and Diagnostics
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Antimicrobial Peptides and Activities
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic Neurodegenerative Diseases
- Monoclonal and Polyclonal Antibodies Research
- Blood Coagulation and Thrombosis Mechanisms
- Mitochondrial Function and Pathology
- Blood groups and transfusion
- Insect Resistance and Genetics
- Celiac Disease Research and Management
Discovery Institute
2024
Sanford Burnham Prebys Medical Discovery Institute
2024
University of Padua
2001-2023
University of Siena
2023
Nuovo Ospedale di Prato
2019-2023
Azienda Usl Toscana Centro
2018-2021
Policlinico San Matteo Fondazione
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
University of Pisa
1982-2019
Ospedale Santa Maria della Misericordia di Udine
2011
A study on malaria transmission, prevalence of infection and anti-sporozoite antibodies was carried out in Burkina Faso (West Africa). The the levels to (NANP)3 were found be related entomological sporozoite inoculation rates measured at same time a defined area. major inducer anti-(NANP)3 antibody production under field conditions is by infected mosquitoes. Levels vary considerably with age transmission season. High raised might offer protection against small inocula sporozoites.
Data suggest that adjuvant human papillomavirus (HPV)-vaccination in women treated for cervical HPV diseases reduces recurrent disease. This study investigates HPV-vaccination and the rate of recurrence undergoing surgery vulvar high-grade squamous intraepithelial lesions (HSIL). From January 2013 to April 2020, we enrolled 149 a prospective case-control study. The control group (NV-group) was by standard alone, while received vaccination soon after (V-group). A follow-up performed...
Synthetic peptides have been used to map linear B-cell epitopes of the third variable (V3) region feline immunodeficiency virus (FIV) external membrane glycoprotein gp120. The analysis sera from naturally and experimentally FIV-infected cats by Pepscan enzyme immunoassay with four partially overlapping evidenced three antibody-binding domains, two which mapped in carboxyl-terminal half V3. In particular, V3.3 sequence (Gly-392-Phe-413) turned out be important for vitro neutralization that...
Specific-pathogen-free cats, immunized with a 22-amino-acid synthetic peptide designated V3.3 and derived from the third variable region of envelope glycoprotein Petaluma isolate feline immunodeficiency virus (FIV), developed high antibody titers to purified virus, as assayed by enzyme-linked immunoassays, well neutralizing antibodies, inhibition syncytium formation in Crandell kidney cells. V3.3-immunized animals control cats were challenged FIV then monitored for 12 months; immunization...
The 190-kilodalton glycoprotein (gp190) of Plasmodium falciparum, the precursor major surface proteins merozoites, is considered a promising candidate for blood stage malaria vaccine. DNA sequences specific gp190 two isolates K1 and MAD20 were subcloned expressed in Escherichia coli. panel fusion obtained represents about 80% polymorphic observed so far within various P. falciparum. Sera from individuals living malaria-endemic area West Africa tested immunoblots against proteins, antibody...
Few population studies are available on epidemiological indexes of hereditary ataxias. An investigation the prevalence rate these movement disorders is in progress for Veneto region, main area northeast Italy with a 4,490,586 inhabitants. The first results this survey concern province Padua, which numbers 845,203 residents (January 1, 2002). inherited ataxias has been estimated at 93.3 cases per million most common types appeared to be autosomal dominant forms, namely spinocerebellar ataxia...
"Detection and Anatomical Localization of Plasmodium falciparum Circumsporozoite Protein Sporozoites in the Afrotropical Malaria Vector Anopheles gambiae S.L." published on Nov 1987 by The American Society Tropical Medicine Hygiene.
Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays role extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has both COPD and atherogenesis. The 2011 GOLD document classified patients according to FEV1, symptoms, exacerbations history, creating four groups, from A (less symptoms/low risk) D (more symptoms/high risk). Extracellular vesicles (EV) represent potential markers COPD: nevertheless, no studies...
Community-based malaria control with integrated primary health care appears to be the most feasible approach for endemic countries in their struggle against malaria. To plan and implement personal protection vector measures, there is need comprehensive information about local modes of transmission. Experience insecticide-based programmes entomological data accumulated over years has revealed systems extraordinary heterogeneity, creating multifaceted transmission situations. The care-system...
Total immunoglobulin content and concentration of immune complexes (IC) were determined in the sera 51 cats infected with feline immunodeficiency virus (FIV) 40 controls. IgG IgM quantified by radial immunodiffusion circulating IC (CIC) CIC-conglutinin assay. fractions obtained acid elution from kidney tissues 15 FIV-infected five negative control to investigate possible role genesis renal damage observed animals. Mean concentrations higher than controls (29.6 +/- 6.7 versus 23.0 1.9 mg/dl...
Seven monoclonal antibodies were obtained after immunization of mice with purified sodium dodecyl sulfate (SDS)-disrupted feline immunodeficiency virus (FIV). Six specifically bound antigens in the cytoplasm FIV-infected cells as determined by indirect immunofluorescence and reacted FIV p24 gag gene product immunoblots. One positively virus-infected cells, but failed to recognize structural proteins immunoblotting. Using competition binding studies, anti-p24 monoclonals shown detect four...
Abstract Tiotropium is a muscarinic antagonist that reduces the risk of acute exacerbations chronic obstructive pulmonary disease, possibly through an as yet incompletely characterized anti-inflammatory activity. We hypothesized activation bronchial epithelial cells and endothelial causes release proinflammatory microparticles tiotropium inhibits phenomenon. Microparticle generation was assessed by functional assay, flow cytometry NanoSight technology. Immortalized (16HBE) umbilical vein...