A5034507804- Chronic Obstructive Pulmonary Disease (COPD) Research
- Extracellular vesicles in disease
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Cardiovascular Disease and Adiposity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Delphi Technique in Research
- Cardiovascular and exercise physiology
- Blood Coagulation and Thrombosis Mechanisms
- High Altitude and Hypoxia
- Cystic Fibrosis Research Advances
- Protease and Inhibitor Mechanisms
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- MicroRNA in disease regulation
- Hydrogen's biological and therapeutic effects
- Cardiac Health and Mental Health
- Medical and Biological Ozone Research
University of Pisa
2016-2025
Azienda Ospedaliera Universitaria Pisana
2016-2025
Azienda Usl Toscana Centro
2020
Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much known about its relationship with other disease features. Aim. To compare airway inflammatory markers clinical and functional findings in subjects stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152 NFCB patients (62.6 years; females: 57.2%) underwent cross-sectional evaluation, including microbiologic cell profile sputum, exhaled breath condensate malondialdehyde (EBC-MDA). severity...
Cancer is characterized by chronic inflammation and hypercoagulability, with an excess of venous thromboembolism (VTE). Tissue factor, the initiator blood coagulation, circulates associated extracellular vesicles (EV-TF). Studies investigating EV-TF between cancer-associated non-cancer-associated VTE are lacking. We therefore compared in unprovoked (U-VTE), (C-VTE), cancer without (C-w/o VTE). also investigated interleukin-6 (IL-6) levels same groups. The final population included 68...
Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are associated with a high rate cardiovascular events. Thromboinflammation (the interplay between coagulation and inflammation) is probably involved in these Extracellular vesicles (EV) increase during AE-COPD, but their role thromboinflammation COPD still unknown. We investigated EV-associated prothrombotic proinflammatory activity COPD.
Cell-derived extracellular vesicles (EVs) found in the circulation and body fluids contain biomolecules that could be used as biomarkers for lung other diseases. EVs from bronchoalveolar lavage (BAL) might more informative of abnormalities than blood, where information diluted. To compare EVs’ characteristics BAL blood smokers with without COPD. Same-day samples were obtained 9 nonsmokers (NS), 11 w/o COPD (S), (SCOPD) (FEV1: 59 ± 3% pred). After differential centrifugation, (200–500 nm...
Introduction: GOLD guideline recommendations are currently the “gold standard” for treatment of COPD patients.Objectives: The objective this analysis was to evaluate compliance with guidelines in managing patients’ by general practitioners (GPs) and pulmonologists. Since inhaled corticosteroid (ICS) use is defined as inappropriate mild moderate patients, special attention paid ICS therapy these classes.Methods: study based on Italian GP database IMS Health Longitudinal Patient Database (IMS...
MicroRNAs (miRNAs) are a class of short non-coding RNAs involved in the regulation gene expression and control several cellular processes at physiological pathological levels. Furthermore, extracellular vesicles (EV), which small membrane-bound secreted by cells environment, contain functional miRNAs. The remarkable deregulation many miRNAs has been demonstrated respiratory diseases. Among them, miR-206, miR-133a-5p, miR-133a-3p striated muscle-specific (myo-miRNA), related to skeletal...
Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays role extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has both COPD and atherogenesis. The 2011 GOLD document classified patients according to FEV1, symptoms, exacerbations history, creating four groups, from A (less symptoms/low risk) D (more symptoms/high risk). Extracellular vesicles (EV) represent potential markers COPD: nevertheless, no studies...
Extracellular vesicles (EVs) play a pivotal role in variety of physiologically relevant processes, including lung inflammation. Recent attention has been directed toward EV-derived microRNAs (miRNAs), such as miR-191-5p, particularly the context Here, we investigated impact miR-191-5p-enriched EVs on activation NF-κB and expression molecules associated with inflammation interleukin-8 (IL-8). To this aim, cells bronchial epithelial origin, 16HBE, were transfected miR-191-5p mimic inhibitor...
<b>Aim:</b> Physiologic and biologic determinants of exercise tolerance in COPD have not been extensively studied. <b>Methods:</b> We examined 45 patients (36 male, age 69.9±7.1 yrs, pack-yrs 50.8±28.2, FEV1 52.5±17.0 %pred) attending to a pulmonary rehabilitation program. All them underwent detailed functional (including static lung function, diffusing capacity, MIP, MEP) (blood sputum inflammatory cells, blood haemoglobin, CRP pro-BNP) evaluation. Exercise capacity was assessed by...
<b>Pulmonary embolism represents an overlooked cause of worsening respiratory failure in COVID-19. A regular bedside evaluation for atypical features like pleuritic chest pain or pleural effusion could help identify suspected cases appropriate management.</b>https://bit.ly/3bbBPqZ
Results of pulmonary rehabilitation programs (PRP) are evaluated using patient-centered outcomes. Since outcomes (exercise capacity and quality life) can be largely subjective, we hypothesized that they may fit to different subgroups COPD patients. We studied 81 patients (58 males; 70.0±7.6 years; FEV1 1.17±0.44 L, 47.3±15.4% predicted), attending an outpatient PRP. After a baseline evaluation (anthropometrics, Medical Research Council – MRC dyspnea score, function test PFTs, 6-minute walk...
In a group of 157 bronchiectasis, subgroup 25 asthmatics was identified. A panel asthma characteristcs included clinical history, risk factors for asthma, functional data (repeated posivitity to reversibility test and/or methacholine test). All subjects were evaluated into protocol bronchiectasis involving imaging analysys as BSI, search bacteria in the airway, spirometric evaluations, measurements airway inflammation indices (induced sputum and FeNO). The with not different from other age,...