A5013624453- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Eosinophilic Esophagitis
- Air Quality and Health Impacts
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Medical and Biological Ozone Research
- Bacterial Infections and Vaccines
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrovascular and genetic disorders
- Peripheral Artery Disease Management
- Vasculitis and related conditions
- IL-33, ST2, and ILC Pathways
- Bacteriophages and microbial interactions
- Climate Change and Health Impacts
- Pneumonia and Respiratory Infections
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Mycobacterium research and diagnosis
- Eosinophilic Disorders and Syndromes
- Cerebrovascular and Carotid Artery Diseases
Hôpital de la Timone
2012-2023
Aix-Marseille Université
2023
University of Pisa
2010-2021
Azienda Ospedaliera Universitaria Pisana
2008-2018
Centre Hospitalier Universitaire de Grenoble
2017
Assistance Publique Hôpitaux de Marseille
2013
Société Française de Médecine Vasculaire
2011-2013
Ospedale Cisanello
2002-2003
Hôpital d'instruction des Armées Desgenettes
1979-1996
Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much known about its relationship with other disease features. Aim. To compare airway inflammatory markers clinical and functional findings in subjects stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152 NFCB patients (62.6 years; females: 57.2%) underwent cross-sectional evaluation, including microbiologic cell profile sputum, exhaled breath condensate malondialdehyde (EBC-MDA). severity...
We investigated whether exposure to ozone (O3) 24 hours after an allergen challenge test would increase airway eosinophilia induced by in subjects with mild asthma late response. Twelve atopic participated a randomized, single-blind study. Subjects underwent before 2 hour O3 (0.27 ppm) or filtered air. Pulmonary function was monitored during the and Six later, sputum collected. After 4 weeks, experiment repeated same subjects. Allergen comparable response both challenges. significant...
Background. Asthma Control Test (ACT) is a simple tool for assessing the level of asthma control in clinical practice, and it has been validated comparison with general assessment control, including forced expiratory volume first second (FEV1). Objective. To evaluate relationship between ACT score functional findings biomarkers airway inflammation. Methods. A total 68 asthmatic patients observed our clinic (33 regularly treated inhaled corticosteroids (ICS) 35 ICS-naïve) filled questionnaire...
Coagulation factor Xa appears involved in the pathogenesis of pulmonary fibrosis. Through its interaction with protease activated receptor-1, this signals myofibroblast differentiation lung fibroblasts. Although fibrogenic stimuli induce X synthesis by alveolar cells, mechanisms local posttranslational activation are not fully understood. Cell-derived microparticles submicron vesicles different physiological processes, including blood coagulation; they potentially activate due to exposure on...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing vasculitis that predominantly affects small- to medium-sized vessels. It characterized by wide spectrum of extrapulmonary symptoms, including sinonasal and paranasal sinus abnormalities. These are the most common features this disease, constituting diagnostic criteria for EGPA. However, actual clinical features, cellular mechanisms impact on patients' quality life (QoL) still matter study.Thirty-nine EGPA patients...
According to ATS/ERS document on severe asthma (SA), the management of these patients requires identification and proper treatment comorbidities, which can influence control asthma.The aim this study was assess independent effect different comorbidities clinical, functional biologic features SA. Seventy-two with SA according GINA guidelines were examined. We collected demographic data, smoking habit, history, assessment comorbidities. Pulmonary function, inflammatory biomarkers, upper airway...
Objectives/Hypothesis To evaluate the clinical features of audiologic impairment and its relationship with nasal, vestibular, rheumatologic profile in a cohort patients eosinophilic granulomatosis polyangiitis (EGPA), formerly named Churg‐Strauss syndrome. Study Design Prospective cross‐sectional study. Methods Thirty‐nine EGPA, considered controlled according to Birmingham Vasculitis Activity Score Damage Index, underwent complete evalutaion otomicroscopy, impedance audiometry, speech...
Proceedings of the European Seminars in Respiratory Medicine course, Inhalation therapy next decade: Determinants adherence to treatment asthma and COPD, held Taormina, Italy, on 3-4 March, 2017
To evaluate the reproducibility of induced sputum analysis, and to estimate sample size required obtained reliable results, was by hypertonic saline inhalation in 29 asthmatic subjects on two different days. The whole method used for inflammatory cells were counted cytospin slides. Reproducibility, expressed intra-class correlation coefficients, good macrophages (+0.80), neutrophils (+0.85), eosinophils (+0.87), but not lymphocytes (+0.15). Detectable differences 5.5% macrophages, 0.6%...
The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. Twenty-three well controlled, treated, mild-to-moderate asthmatic patients underwent two sequential randomised exposures either filtered air or (0.3 ppm 2 hours) a challenge chamber. Pulmonary function (PF) was monitored, FEV1 decrease greater than 10% from pre-challenge value were...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous characterized by combination of 3 different disorders, namely chronic asthma, bronchitis and emphysema, sometimes simultaneously present in the same subject.The aim our study was to compare sputum inflammatory markers patients with phenotypes airway obstruction.Forty-five subjects (forced expiratory volume 1 s/vital capacity, FEV(1)/VC: 58.8 +/- 12.2%; FEV(1): 49.8 11.5% predicted) were classified as asthma (n = 10) or COPD 35);...
The aim of this study was to assess whether hyperosmolarity affects granulocyte mediator levels in induced sputum asthmatic subjects. A total 32 mild-to-moderate asthmatics, who inhaled either hypertonic (HS; 4.5% NaCl) or isotonic (IS; 0.9% solutions for 15 min, were studied. Selected used analysis. Eosinophil cationic protein (ECP), eosinophil X (EPX), myeloperoxidase (MPO) and free neutrophil elastase (NE) measured supernatant. Sample weight, differential cell counts, as well viability...
Both inflammatory and remodelling processes are associated with irreversible airway obstruction observed in severe asthma. Our aim was to characterize a group of asthmatic patients or without persistent relation specific sputum biomarkers.Forty-five under regular high-dose inhaled corticosteroid/ß-2agonist treatment were studied, after follow-up period at least 2 years, minimum 4 visits. Periostin, TGF-ß, RANTES, IL-8, GM-CSF, FGF-2, cell counts measured induced sputum. Serum periostin also...
Context: It is well known that ozone exposure decreases lung function and increases airway neutrophilia, but large variability has been observed among asthmatic patients.Objective: To find possible predictors of functional inflammatory response to in patients.Materials methods: We studied 120 patients with mild-to-moderate asthma, randomly exposed either air or (0.3 ppm for 2 h) a challenge chamber. Symptoms pulmonary test (PFT) were measured before immediately after exposure. Six hours...
Acute airway inflammation is considered to characterize asthma exacerbations, but its specific cellular pattern has not yet been completely evaluated.To evaluate the prevalence of sputum eosinophilia during acute exacerbations moderate severity, compared with a stable phase disease, and assess concordance between changes in pulmonary function period exacerbation post exacerbation.We blood inflammatory cell counts 29 asthmatic subjects spontaneous (visit 1) measured 4 weeks after resolution...