A5081367721- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cystic Fibrosis Research Advances
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Delphi Technique in Research
- Respiratory Support and Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Reproductive Health and Technologies
- Obesity, Physical Activity, Diet
- Inhalation and Respiratory Drug Delivery
- Physical Activity and Health
- Childhood Cancer Survivors' Quality of Life
- COVID-19 and Mental Health
- Infection Control and Ventilation
- COVID-19 epidemiological studies
- Adolescent and Pediatric Healthcare
- Behavioral Health and Interventions
- Pregnancy and Medication Impact
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
Institute of Social and Preventive Medicine
2017-2025
University of Bern
2017-2025
Odense University Hospital
2023
University Hospital of Bern
2022
University Children’s Hospital Basel
2021-2022
University Children's Hospital Zurich
2022
University of Zurich
2022
Kantonsspital Aarau
2021-2022
University of Lucerne
2022
Copenhagen Business School
2021
Since the publication of European Respiratory Society (ERS) task force reports on management preschool wheezing in 2008 and 2014, a large body evidence has accumulated suggesting that clinical phenotypes were proposed (episodic (viral) multiple-trigger wheezing) do not relate to underlying airway pathology may help determine response treatment. Specifically, using alone no longer be appropriate, new approaches can used inform care are needed for future research. This ERS reviewed literature...
Abstract Introduction Pulmonary exacerbations contribute to disease progression in chronic lung diseases. In a large prospective cohort study, we studied the incidence and predictors of pulmonary among persons with primary ciliary dyskinesia (PCD), which can inform follow-up care. We also assessed healthcare use, changes management, pathogens during exacerbations. Methods Participants Living PCD study reported increased respiratory symptoms past seven days, indicating exacerbation, from June...
Primary ciliary dyskinesia (PCD) presents with symptoms early in life and the disease course may be progressive, but longitudinal data on lung function are scarce. This multinational cohort study describes trajectories children, adolescents young adults PCD. We analysed from 486 patients repeated measurements obtained between age of 6 24 years International PCD Cohort calculated z-scores for forced expiratory volume 1 s (FEV1), vital capacity (FVC) FEV1/FVC ratio using Global Lung Function...
Accelerometers can obtain precise measurements of movements during the day. However, individual activity pattern varies from day-to-day and there is limited evidence on measurement days needed to sufficient reliability. The aim this study was examine variability in accelerometer derived data sedentary behaviour physical at work leisure-time week among Danish office employees. We included control participants (n = 135) Take a Stand! Intervention; cluster randomized controlled trial conducted...
What is the prevalence of infertility and ectopic pregnancies among individuals with primary ciliary dyskinesia (PCD)?
Background Primary ciliary dyskinesia (PCD) affects fertility in both women and men. To understand the impact concerns among people with PCD parents of affected children (family caregivers), we explored how they report their experiences fertility. Methods We used qualitative data from a questionnaire on Living , an international participatory study. In optional open-ended comment fields, participants shared thoughts related to adopted conventional content analysis analysed inductively....
ABSTRACT Introduction Prolonged or recurrent cough is a common reason for referral to pediatric pulmonologists, yet few studies have assessed its causes. We examined records of children visiting respiratory outpatient clinics in Switzerland and how diagnoses vary by age. Methods analyzed data from the multicenter Swiss Paediatric Airway Cohort study. included 363 (median age 6 years, range 0–16) referred prolonged cough. From records, we extracted information on diagnostic investigations,...
Background: Adolescents and young adults with cancer (AYA) represent a distinct patient group unique challenges. Most studies reporting outcomes use registry data, leaving local care aspects underreported. Aim: To understand demographic clinical characteristics of AYA patients focusing on variations by type, sex, age, as well fertility preservation, palliative care, trial participation, survival outcomes. Methods: A retrospective single centre study examined electronic medical records (age...
STUDY AIMS: Routinely collected health data are increasingly used for research; however important anamnestic details may be missing from medical records. We compared physician documentation of paediatric exercise-induced respiratory symptoms in clinical notes with parental questionnaire responses the same children. METHODS: analysed Swiss Paediatric Airway Cohort (SPAC), a multicentre observational study children treated outpatient pulmonology clinics. included aged 6 to 17 years who were...
Introduction There are few data on the usefulness of different tests to diagnose asthma in children. Aim We assessed contribution a detailed history and variety diagnostic for diagnosing Methods studied children aged 6–16 years referred consecutively evaluation suspected two pulmonary outpatient clinics. Symptoms were by parental questionnaire. The clinical included skin-prick tests, measurement exhaled nitric oxide fraction ( F eNO ), spirometry, bronchodilator reversibility bronchial...
Background: The Physical Activity Scale (PAS2) was developed to measure physical activity (PA) during work, transportation and leisure time, in the Danish adult population. objective of this study assess criterion validity PAS2 against a combined accelerometer heart rate monitor adults investigate if differed by socio-demographic factors body mass index. Method: A total 330 (mean age = 46.7 years, 38.5% men) participating Health2008 completed questionnaire wore sensor for seven days. Average...
Introduction Diagnosing asthma in children remains a challenge because respiratory symptoms are not specific and vary over time. Aim In real-life observational study, we assessed the diagnostic accuracy of symptoms, objective tests two paediatric algorithms (proposed by Global Initiative for Asthma (GINA) National Institute Health Care Excellence (NICE)) diagnosis school-aged children. Methods We studied aged 5–17 years who were referred consecutively to pulmonary outpatient clinics...
COVID-PCD is a participatory study initiated by people with primary ciliary dyskinesia (PCD) who have an essential vote in all stages of the research from design to recruitment participants, and interpretation communication results. aims collect epidemiological data real-time PCD throughout pandemic describe incidence coronavirus disease 2019 (COVID-19), symptoms course disease; identify risk factors for prognosis; assess experiences, wishes needs. The advertised through patient support...
The distinction between episodic viral wheeze (EVW) and multitrigger (MTW) is used to guide management of preschool wheeze. It has been questioned whether these phenotypes are stable over time. We examined the temporal stability MTW EVW in two large population-based cohorts. classified children from Avon Longitudinal Study Parents Children (n=10 970) Leicester Respiratory Cohorts ((LRCs), n=3263) into EVW, no at ages 2, 4 6 years based on parent-reported symptoms. Using multinomial...
Chronic respiratory symptoms, such as cough, wheeze and dyspnoea, are common in children; however, most research has, with the exception of a few large-scale clinical cohort studies, been performed general population or small, highly-selected samples. The Swiss Paediatric Airway Cohort (SPAC) is national, prospective children adolescents who visit physicians for recurrent conditions, exercise-related problems. SPAC an observational study baseline assessment includes standardised...
Objectives: Primary ciliary dyskinesia (PCD) is a rare genetic disease that causes recurrent respiratory infections. People with PCD may be at high risk of severe COVID-19 and protection against SARS-CoV-2 therefore important. We studied facemask usage problems reported in relation their use among people PCD. Methods: used data from COVID-PCD, an international observational cohort study. A questionnaire was e-mailed to participants October 2020 asked about usage. Results: In total, 282 27...
References from the Global Lung Function Initiative (GLI) are widely used to interpret children's spirometry results. We assessed fit for healthy schoolchildren.LuftiBus in School was a population-based cross-sectional study undertaken 2013-2016 canton of Zurich, Switzerland. Parents and their children aged 6-17 years answered questionnaires about respiratory symptoms lifestyle. Children underwent mobile lung function lab. calculated GLI-based z-scores forced expiratory volume 1 s (FEV1),...
Mostly derived from chart reviews, where symptoms are recorded in a nonstandardised manner, clinical data about primary ciliary dyskinesia (PCD) inconsistent, which leads to missing and unreliable information. We assessed the prevalence frequency of respiratory ear studied differences by age sex among an unselected population Swiss people with PCD.We sent questionnaire that included items FOLLOW-PCD standardised all PCD registry participants.We received questionnaires 74 (86%) out 86 invited...
Respiratory disease is common in children and strongly associated with lifestyle environmental exposures. Thus, it important to study the epidemiology locally. The LuftiBus School (LUIS) was set up assess respiratory health of schoolchildren canton Zurich, Switzerland. LUIS a cross-sectional population-based that carried out 2013 2016. Children aged 6–17 years living Zurich were eligible participate. All schools approached school head decided whether would participate which classes....