A5025569441- Reconstructive Surgery and Microvascular Techniques
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Surgical Sutures and Adhesives
- Breast Implant and Reconstruction
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Facial Rejuvenation and Surgery Techniques
- Soft tissue tumor case studies
- Vascular Tumors and Angiosarcomas
- Reconstructive Facial Surgery Techniques
- Cutaneous Melanoma Detection and Management
- Mesenchymal stem cell research
- Chemotherapy-related skin toxicity
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Pressure Ulcer Prevention and Management
- Cancer Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Body Contouring and Surgery
- Cancer Treatment and Pharmacology
- Vascular Malformations and Hemangiomas
- Systemic Sclerosis and Related Diseases
- Genetic and rare skin diseases.
- Surgical site infection prevention
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2011-2024
Plastic Surgery Hospital
2021
Ospedale di Livorno
2020
Ospedale San Pietro Fatebenefratelli
2012-2013
University of Perugia
2008-2011
Istituto Giannina Gaslini
2009
Fatebenefratelli Hospital
1998
The present study was designed to evaluate the clinical outcome of cell-based therapy with cultured adipose derived stromal cells (ASCs) for treatment cutaneous manifestations in patients affected by systemic sclerosis (SSc). ASCs have an extraordinary developmental plasticity, including ability undergo multilineage differentiation and self-renewal. Moreover, can be easily harvested from small volumes liposuction aspirate, showing great vitro viability proliferation rate. Here we isolated,...
Abstract Background The use of conservative mastectomies has risen significantly during the last few years. reconstructive choice direct-to-implant reconstruction become more practicable with modern mastectomy techniques. initial trend in Italian centers was to dual-plane hybrid reconstruction. However, a high level complications been registered. From 2015 onward, our centers, pre-pectoral approach adopted. authors sought describe gradually discard sub-pectoral technique lower lateral pole...
Background. Systemic sclerosis (SSc) is a multisystem disease characterized by cutaneous and visceral fibrosis. Face mouth changes include telangiectasia, sicca syndrome, thinning reduction of width (microcheilia) opening (microstomia). We applied autologous fat transplantation compared with adipose-derived stromal cells (ADSCs) injection to evaluate the clinical improvement opening. Methods. From February May 2013 ten consecutive SSc patients were enrolled from outpatient clinic Plastic...
Giant condyloma acuminatum (GCA) is a slow-growing, large, cauliflower-like tumor located in the anogenital region. This has locally destructive behavior, high recurrence rate and occasional transformation to squamous cell carcinoma. Risk factors include anoreceptive intercourse, HIV immunosuppression. There no general agreement on choice of treatment for this tumor. Wide radical excision with plastic reconstruction skin defects seems be best treatment, while adjuvant therapies, such as...
Results of a national retrospective survey on Hyalomatrix PA in burn patients are reported. A total 11 centers were contacted. 57 available. was used young and adult patients, mainly deep partial thickness full burns. In most cases, applied immediately after the wound cleaning (wound debridement or escharectomy for adults, dermabrasion patients). After 7 days, reepithelization processes more frequent One-half patient population underwent grafting. 29 complete closure achieved almost all...
Hypertrophic and contracture scars are common problems after burn injuries cause functional cosmetic deformities. A wide variety of treatments has been advocated for postburn pathologic regression. Unfortunately, the reported efficacy variable.To investigate use extracorporeal shock wave therapy (ESWT), which mainly targets fibroblasts in scar tissue, as an effective modality treatment patients.An experimental study with ESWT was performed 16 patients contractures, hypertrophic scars, or...
Malar bags are a common aesthetic concern characterized by swelling and puffiness in the prezygomatic space cheek area. Various medical surgical techniques have been developed to address this condition restore more youthful rejuvenated appearance. In terms of therapies, non-invasive options such as topical creams containing retinoids, peptides, hyaluronic acid shown promise reducing mild malar bags. These substances help improve skin texture, promote collagen production, enhance elasticity,...
We discuss our experience with antineoplastic drug extravasation. Between December 1988 and 1990, 40 patients cytostatic extravasation lesions of varying seriousness were observed. In these patients, whenever possible, depending on the amount time that elapsed since accident severity lesion, conservative therapy was done. The procedure consisted local injection a considerable saline solution (20-90 ml, site extravasation) topical occlusive applications corticosteroids locally. all this...
Abstract Non‐invasive ventilation ( NIV ) provides an effective ventilatory support in patients with respiratory failure without endotracheal intubation. However, there are potential problems its clinical application and the development of pressure ulcers represents a common complication. Often several intensive care units treat facial skin breakdown related to . In this article, we report our experience treatment prevention these lesions, emphasising higher risk certain age groups develop...
The skin graft is a surgical technique commonly used in the reconstructive surgery of limbs, order to repair loss, as well donor area flaps and cover dermal substitutes after engraftment. unavoidable side effect this consists unaesthetic scars. In achieve healing posttraumatic ulcers by means tissue regeneration avoid excessive scarring, new innovative technology based on application autologous micrografts, obtained Rigenera technology, was reported. This able induce highly viable...
"Vulvar dystrophy" is characterized by chronic alterations of vulvar trophism, occurring in both physiological (menopause) and pathological (lichen sclerosus, graft-versus-host disease) conditions. Associated symptoms are itching, burning, dyspareunia vaginal dryness. Current treatments often do not imply a complete remission symptoms. Adipose-Derived Stem Cells (ADSCs) injection represents valid alternative therapy to enhance trophism tone dystrophic tissues. We evaluated efficacy...
Malignant degeneration of wounds is rare and often misdiagnosed. Delay in diagnosis may result a worse prognosis. The aim this study to determine the number skin cancers associated with chronic ulcers our facility over period 10 years. Between January 2002 December 2012, total about 1000 patients had consulted us for wounds, especially vascular, diabetic traumatic origin pressure ulcers. Thirteen been detected: seven squamous cell five basal carcinomas one melanoma. We highlight how...
More than 50% of breast cancer care occurs in elderly but women aged 65 and over generally have lower reconstruction (BR) rates. In medical literature, few papers focused on BR patients usually the reported techniques are multisteps such as expander-implant reconstruction, local, free flaps. We present a one-stage technique employed patients: muscle-sparing immediate with subcutaneous implant Braxon acellular dermal matrix. prove feasibility safety believe that this new procedure could...
Chemotherapy extravasation may result in serious damage to patients, with irreversible local injures and disability. Evidence-based standardization on management is lacking many institutions do not practice adequate procedures prevent the severer damages. Our aim was explore prevention treatment of injuries, proposing a standard therapeutic protocol together review literature. From January 1994 December 2015, 545 cases were reviewed (age range, 5-87 years; 282 men 263 women). consisted...
Adipogenesis is regulated by a complex network of molecules, including fibroblast growth factors. Keratinocyte factor (KGF) has been previously reported to promote proliferation on rat preadipocytes, although the expression its specific receptor, FGFR2-IIIb/KGFR, not actually detected in mesenchymal cells. Here, we demonstrate that human adipose-derived stem cells (ASCs) show increased KGF during adipogenic differentiation, especially early steps. Moreover, able induce transient activation...
Extensive skin defect represents a real problem and major challenge in plastic reconstructive surgery. On one hand, grafts offer practical method to deal with defects despite their unsuitability for several complicated wounds. the other negative pressure wound therapy (NPWT), applied before grafting, promotes granulation tissue growth. The aim of study is evaluate improvement healing given by merger these two different approaches. We treated 23 patients large wounds multiple factors. Of...
Linear scleroderma and Parry-Romberg Syndrome (PRS) are chronic diseases that can affect the face, with patients therefore requiring facial volumetric correction.We have used poly-L-lactic acid (PLLA) to treat asymmetry in linear PRS, because it restore defects has been proven be safe.Since February 2004, we treated six patients: four two PRS. The were every 4 weeks for three five sessions. Photographic documentation was taken at beginning completion of treatment 12 18 months later.In PRS...