A5085649082- Carcinogens and Genotoxicity Assessment
- Occupational and environmental lung diseases
- Breast Cancer Treatment Studies
- Air Quality and Health Impacts
- DNA Repair Mechanisms
- Cancer Treatment and Pharmacology
- Reproductive Biology and Fertility
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Effects and risks of endocrine disrupting chemicals
- Cancer Immunotherapy and Biomarkers
- Glutathione Transferases and Polymorphisms
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Colorectal Cancer Treatments and Studies
- Breast Lesions and Carcinomas
- Ovarian function and disorders
- Health, Environment, Cognitive Aging
- Multiple and Secondary Primary Cancers
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Indoor Air Quality and Microbial Exposure
- Genetically Modified Organisms Research
- Cancer Diagnosis and Treatment
Ospedale Policlinico San Martino
2016-2025
University of Genoa
1994-2020
Université Libre de Bruxelles
2018
Cleveland Clinic
2018
Institut Jules Bordet
2018
Ospedale San Giovanni Bellinzona
2018
Ninewells Hospital
2018
Alleanza Contro il Cancro
2000-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2016
National Cancer Research Institute
2001-2015
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker chromosomal damage and genome stability human populations. Much theoretical evidence has been accumulated supporting the causal role MN induction cancer development, although prospective cohort studies are needed to validate risk biomarker. A total 6718 subjects from 10 countries, screened 20 laboratories for between 1980 2002 ad hoc or routine cytogenetic surveillance, were selected...
Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage human populations. The first results of an analysis pooled data from laboratories using the cytokinesis-block micronucleus (CBMN) assay and participating HUMN (HUman MicroNucleus project) international collaborative study are presented. effects laboratory protocol, scoring criteria, host factors on baseline micronucleated binucleate cell (MNC) frequency...
Background: The occurrence of spontaneous tumors in pet animals has been estimated a few European and North American veterinary cancer registries with dissimilar methodologies variable reference populations. Objectives: Animal Tumor Registry (ATR) Genoa, Italy, was established 1985 the aim estimating dogs. Methods: Six thousand seven hundred forty‐three tumor biopsy specimens were received from local veterinarians Municipality Genoa between 2002. Three three (48.9%) specimen samples...
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results epidemiological studies that associated CA frequency in peripheral lymphocytes healthy individuals future incidence. To overcome limitations single and evaluate strength this association, a pooled analysis was carried out. The database included 11 national cohorts total 22 358 cancer-free who underwent genetic screening with for biomonitoring purposes during 1965-2002...
The aim of this study was to determine the association between dietary intake, determined using a food frequency questionnaire, and genome damage in lymphocytes measured micronucleus (MN) assay. study, performed on 190 healthy individuals (mean age 47.8 years, 46% males), also examined whether supplementation with β-carotene, vitamins C E along zinc (ACEZn), randomized trial for 6 months, improves stability. Multivariate analysis baseline data showed that (1) highest tertile intake vitamin...
There is evidence that increased frequency of chromosomal aberration (CA) in peripheral blood lymphocytes a predictor cancer, but further data are needed to better characterize CA as marker cancer risk. From the archives 15 laboratories we gathered cytogenetic records 11,834 subjects who were free at moment drawing and underwent examination for preventive purposes Czech Republic during 1975–2000. We linked these national registry, revealing total 485 cases. Subjects classified according...
Abstract Purpose: High levels of serum-soluble mesothelin family proteins (SMRP) have been found to be associated with malignant mesothelioma (MM), but not lung cancer (LC). To verify the clinical role this marker for both these tumors, we tested serum SMRP in largest population thoracic cancers ever assembled. Experimental Design: blood concentrations were measured 107 patients MM, 215 LC, 130 benign respiratory diseases (BRD), and 262 controls. Statistical comparison between mean all...
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate risk overall mortality, mortality by cause, cancer incidence associated damage, cohort 2,403 healthy individuals (25,978 person-years) screened 16 laboratories using between 1996 2016 was followed-up. Kaplan-Meier analysis indicated worse survival medium high tertile damage (p < 0.001). effect on modelled according...