A5090730634- Carcinogens and Genotoxicity Assessment
- Thyroid Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Microplastics and Plastic Pollution
- BRCA gene mutations in cancer
- Effects and risks of endocrine disrupting chemicals
- Recycling and Waste Management Techniques
- Dialysis and Renal Disease Management
- Glutathione Transferases and Polymorphisms
- Genetic Associations and Epidemiology
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Folate and B Vitamins Research
- Nanoparticles: synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Genetically Modified Organisms Research
- Thyroid Disorders and Treatments
- RNA modifications and cancer
- Water Treatment and Disinfection
- Acute Lymphoblastic Leukemia research
- CRISPR and Genetic Engineering
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Chronic Kidney Disease and Diabetes
- Molecular Biology Techniques and Applications
Universitat Autònoma de Barcelona
2015-2024
Instituto de Salud Carlos III
2010-2021
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2011-2020
Centro Científico Tecnológico - San Juan
2020
Environmental Mutagenesis and Genomics Society
2019
Centro de Investigación Biomédica en Red
2013-2014
Joint Research Centre
2008-2010
Syngenta (United States)
2009
University of Fort Lauderdale
1980
Our results show that both nPS are easily internalized by Caco-2 cells in a concentration-dependent manner, but no relevant toxic effects observed under the analyzed exposure conditions.
Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12 (NRG1), 9q22.33 (FOXE1), and 14q13.2 (NKX2-1). However, most the inherited genetic risk factors DTC remain to be discovered. Our objective was identify additional common susceptibility loci. We conducted a GWAS in high-incidence Italian population 690 cases 497 controls followed up significant 2 series 3 low-incidence populations totaling 2958...
The increasing presence of micro- and nanoplastics (MNPLs) in the environment, their consequent accumulation trophic niches, could pose a potential health threat to humans, especially due chronic ingestion. In vitro studies using human cells are considered pertinent approaches determine risks humans. Nevertheless, most such have been conducted short exposure times high concentrations. Since MNPLs is supposed be chronic, there lack information regarding effects under conditions. To this aim,...
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate risk overall mortality, mortality by cause, cancer incidence associated damage, cohort 2,403 healthy individuals (25,978 person-years) screened 16 laboratories using between 1996 2016 was followed-up. Kaplan-Meier analysis indicated worse survival medium high tertile damage (p < 0.001). effect on modelled according...
The environmental presence of micro/nanoplastics (MNPLs) is an and human health concern. Such MNPLs can result from the physicochemical/biological degradation plastic goods (secondary MNPLs) or industrial production at that size, for different commercial purposes (primary MNPLs). Independently their origin, toxicological profile be modulated by as well ability cells/organisms to internalize them. To get more information on these topics we have determined three sizes polystyrene (50, 200, 500...
This paper presents the results obtained within framework of an EU research project aimed at investigating relationship between occupational exposure to pesticides and induction cytogenetic damage. Populations from Greece, Spain, Poland Hungary, all them characterised by intensive agricultural activity, were subject study. A total 239 workers 231 unexposed controls examined for effects in lymphocytes peripheral blood exfoliated cells oral mucosa. The frequency micronuclei (MN) was evaluated...
The presence of plastic waste in our environment has continued growing and become an important environmental concern. Because its degradation into micro- nanoplastics (MNPLs), MNPLs are becoming pollutants special environmental/health Since ingestion is one the main exposure routes to MNPLs, potential effects digestion on physicochemical/biological characteristics polystyrene (PSNPLs) were determined. results indicated a high tendency digested PSNPLs agglomerate differential proteins their...
The potential cytogenetic damage associated with pesticide use in Greek agricultural workers was evaluated using micronuclei (MN) as biomarkers lymphocytes of peripheral blood and exfoliated cells the buccal mucosa. In addition, effects exposure other variables on cytokinesis block proliferation index (CBPI) were also evaluated. Both exposed control individuals selected from Nea Makri, a village near Athens (Greece). This location for its high greenhouse density. Micronuclei analysed 50 to...
Abstract Chronic kidney disease (CKD) patients have many affected physiological pathways. Variations in the genes regulating these pathways might affect incidence and predisposition to this disease. A total of 722 Spanish adults, including 548 174 controls, were genotyped better understand effects genetic risk loci on susceptibility CKD. We analyzed 38 single nucleotide polymorphisms (SNPs) candidate associated with inflammatory response (interleukins IL-1A , IL-4 IL-6 IL-10 TNF-α ICAM-1)...
The increasing presence of secondary micro/nanoplastics (MNPLs) in the environment requires knowing if they represent a real health concern. To such end, an important point is to test representative MNPLs as denominated true-to-life MNPLs, resulting from degradation plastic goods lab conditions. In this study, we have used polyethylene terephthalate (PET) NPLs PET water bottles. Since inhalation exposure route environmental MNPLS, mouse alveolar macrophages (MH-S) target cell, and study...
The increased environmental presence of micro-/nanoplastics (MNPLs) and the potential health risks associated with their exposure classify them as pollutants special concerns. Consequently, there is an urgent need to investigate secondary MNPLs. In this context, using "true-to-life" MNPLs, resulting from laboratory degradation plastic goods, may be a sound approach. These non-commercial MNPLs must labeled track presence/journeys inside cells or organisms. Because cell internalization...
Background: Chronic renal failure (CRF) patients present a high incidence of cardiovascular pathologies and cancer. This has been attributed to the existence genomic instability in these patients, consequently they should elevated levels genetic damage.
Genome-wide association studies (GWASs) on differentiated thyroid cancer (DTC) have identified robust associations with single nucleotide polymorphisms (SNPs) at 9q22.33 (FOXE1), 14q13.3 (NKX2-1), and 2q35 (DIRC3). Our recently published GWAS suggested additional susceptibility loci specific for the high-incidence Italian population.The purpose of this study was to identify novel Italian-specific DTC risk variants based our test them further in low-incidence populations.We investigated 45...
Thyroid cancer is the most heritable of all those not displaying typical Mendelian inheritance. However, genetic factors that would explain high heritability remain unknown. Our aim was to identify additional common variants associated with susceptibility this disease. In order do so, we performed a genome‐wide association study in series 398 cases and 502 controls from Spain, followed by replication four well‐defined Southern European case‐control collections contributing total 1,422 1,908...
Abstract The frequency of micronuclei (MN) in peripheral blood lymphocytes and buccal epithelial cells was used as a biomarker genotoxic effects resulting from occupational exposure to pesticides. In addition, the cytokinesis‐block proliferation index (CBPI) calculated detect possible variations proliferative kinetics due pesticide exposure. This study performed on 84 pesticide‐exposed workers 65 unexposed controls Hungary. workers, classified moderately highly exposed, were also evaluated...
Swimming in pools is a healthy activity that entails exposure to disinfection by-products (DBPs), some of which are irritant and genotoxic. We evaluated DBPs during swimming chlorinated pool the association with short-term changes genotoxicity lung epithelium permeability biomarkers. Non-smoker adults (N = 116) 40 min an indoor were included. measured range biomarkers before at different times after swimming: trihalomethanes (THMs) exhaled breath (5 min), trichloroacetic acid (TCAA) urine...
Thyroid cancer risk involves the interaction of genetic and environmental factors. The thyroperoxidase (TPO) has a key role in iodine metabolism, being essential for thyroid function. Mutations TPO gene are common congenital hypothyroidism, there also signs implication cancer. We performed case-control association study variants differentiated carcinoma (DTC) 1,586 DTC patients 1,769 controls including two European populations (Italy: 1,190 1,290 controls; Spain: 396 479 controls)....
Abstract A genome-wide association study (GWAS) performed on a high-incidence Italian population followed by replications low-incidence cohorts suggested strong of differentiated thyroid cancer (DTC) with single nucleotide polymorphisms (SNPs) at 9q22.33, 2q35, 20q11.22-q12 and 14q24.3. Moreover, six additional susceptibility loci were associated the disease only among Italians. The present had two aims, first to identify involved in DTC risk then assess cumulative effect SNPs identified so...