A5086466612- Carcinogens and Genotoxicity Assessment
- Nanoparticles: synthesis and applications
- Frailty in Older Adults
- DNA Repair Mechanisms
- Nutrition and Health in Aging
- Marine Toxins and Detection Methods
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Effects and risks of endocrine disrupting chemicals
- Heavy Metal Exposure and Toxicity
- Microplastics and Plastic Pollution
- Genetically Modified Organisms Research
- Environmental Toxicology and Ecotoxicology
- Pesticide Exposure and Toxicity
- Air Quality and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Selenium in Biological Systems
- Tryptophan and brain disorders
- Higher Education Teaching and Evaluation
- Protist diversity and phylogeny
- Microbial metabolism and enzyme function
- E-Learning and Knowledge Management
- Anesthesia and Neurotoxicity Research
- Occupational and environmental lung diseases
- Health, Environment, Cognitive Aging
Instituto de Investigación Biomédica de A Coruña
2020-2025
Complexo Hospitalario Universitario A Coruña
2023-2025
Universidade da Coruña
2015-2024
Universidade do Porto
2017-2020
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018
Center for Psychobiology and Behavioral Medicine
2016
In-Q-Tel
2016
IRCCS Ospedale San Raffaele
2013-2015
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2013-2015
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2015
Frailty denotes a multidimensional syndrome that gives rise to vulnerability stressors and leads an increase of the age-related decline different physiological systems cognitive abilities. Aging-related alterations immune system may compromise its competence culminating in chronic low-grade inflammation state. Thus, it has been proposed frailty is associated with concentration pro-inflammatory molecules lymphocyte subpopulations. To provide further support validity hypothesis, we conducted...
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate risk overall mortality, mortality by cause, cancer incidence associated damage, cohort 2,403 healthy individuals (25,978 person-years) screened 16 laboratories using between 1996 2016 was followed-up. Kaplan-Meier analysis indicated worse survival medium high tertile damage (p < 0.001). effect on modelled according...
Due to their extensive use, the release of zinc oxide nanoparticles (ZnO NP) into environment is increasing and may lead unintended risk both human health ecosystems. Access ZnO NP brain has been demonstrated, so potential toxicity on nervous system a matter particular concern. Although evaluation reported in several previous studies, specific effects are not completely understood and, particularly, genetic material organism behaviour poorly addressed. We evaluated toxic vitro vivo, role ions (Zn
Abstract Superparamagnetic iron oxide nanoparticles (ION) have attracted great interest for use in several biomedical fields. In general, they are considered biocompatible, but little is known of their effects on the human nervous system. The main objective this work was to evaluate cytotoxicity two ION (magnetite), coated with silica and oleic acid, previously determining possible interference methodological procedures assure reliability results obtained. Human neuroblastoma SHSY5Y...
There are substantial inter-laboratory variations in the levels of DNA damage measured by comet assay. The aim this study was to investigate whether adherence a standard assay protocol would reduce variation reported values damage. Fourteen laboratories determined baseline level strand breaks (SBs)/alkaline labile sites and formamidopyrimidine glycosylase (FPG)-sensitive coded samples mononuclear blood cells (MNBCs) from healthy volunteers. were technical problems seven adopting protocol,...
The alkaline comet assay is an established, sensitive method extensively used in biomonitoring studies. This can be modified to measure a range of different types DNA damage. However, considerable differences the protocols by research groups affect inter-laboratory comparisons results. aim this study was assess inter-laboratory, intra-laboratory, sample and residual (unexplained) variations strand breaks formamidopyrimidine glycosylase (FPG)-sensitive sites measured using balanced Latin...