A5071733291- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Advanced Breast Cancer Therapies
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Urological Disorders and Treatments
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Social Media in Health Education
University of Southern California
2017-2022
Olive View-UCLA Medical Center
2022
Harbor–UCLA Medical Center
2022
USC Norris Comprehensive Cancer Center
2018-2020
Keck Hospital of USC
2018
University of Toronto
2011-2017
St. Michael's Hospital
2011-2017
Princess Margaret Cancer Centre
2016
University of Calgary
2016
Queen's University
2016
The natural history and prognosis of appendiceal adenocarcinomas differ from those arising in other large bowel sites. We aimed to compare the molecular profiles exhibited by colorectal cancers, or between histopathologic subtypes adenocarcinoma.A total 183 samples adenocarcinoma [46 adenocarcinoma, not otherwise specified (NOS), 66 pseudomyxoma peritonei (PMP), 44 mucinous (MU), 27 signet ring cell carcinoma (SR)], 994 right-sided cancer (R-CRC), 1,080 left-sided CRC (L-CRC) were analyzed...
Abstract Purpose: GEP-NENs are rare malignancies with increasing incidence. Their molecular characteristics still undefined. We explored the underlying biology of and differences between gastrointestinal (GI) pancreatic (PNEN), high-grade (HG), low-grade (LG) tumors. Experimental Design: were analyzed using next-generation sequencing (NGS; MiSeq on 47 genes, NextSeq 592 genes), IHC, in situ hybridization. Tumor mutational burden (TMB) was calculated basis somatic nonsynonymous missense...
Cancer management requires coordinated care from many health providers, and its complexity physicians be up to date on current research. Web-based social media support physician collaboration information sharing, but the extent which use for these purposes remains unknown. The complex field of oncology will benefit increased online enhance communication, education, mentorship. To facilitate this, patterns among oncologists must better understood.A nine-item survey investigating use, designed...
Tertiary lymphoid structures (TLSs) provide an immunological antineoplastic effect. Recent evidences link a unique 12-chemokine (CCL2, -3, -4, -5, -8, -18, -19, -21, CXCL9, -10, -11, -13) signature status from tumor tissue and the TLS expression. However, potential significance of for clinical use is unknown. We aimed to evaluate association with patient outcomes in colorectal cancer (CRC). used integrated data resected 975 CRC cases within three independent cohorts France, Japan United...
Microcalcifications (MCs) are tiny deposits of calcium in breast soft tissue. Approximately 30% early invasive cancers have fine, granular MCs detectable on mammography; however, their significance tumorigenesis is controversial. This study had two objectives: (1) to find associations between mammographic and tumor pathology, (2) compare the diagnostic value mammograms biopsies identifying malignant MCs. A retrospective chart review was performed for 937 women treated cancer during 2000–2012...
Abstract Lymph nodes (LNs) and distant metastases can arise from independent subclones of the primary tumor. Herein, we characterized molecular landscape differences between LNs, colorectal cancers (CRCs). Samples were analyzed using next generation sequencing (NGS, MiSeq on 47 genes, NextSeq 592 genes) immunohistochemistry. Tumor mutational burden (TMB) was calculated based somatic nonsynonymous missense mutations, microsatellite instability (MSI) evaluated by NGS known MSI loci. In total,...
<i>Objectives:</i> Bladder and prostate cancers occur with increasing prevalence in the ageing population. Our study aims to quantify incidence of cancer patients undergoing cystoprostatectomy for bladder assess impact that incidental on oncological outcome. <i>Methods Materials:</i> We retrospectively reviewed pathology reports 128 men who underwent cancer. <i>Results:</i> Twenty-three (18%) were found have All organ confined 91% well or moderately...
3588 Background: Gene fusions involving R-spondin ( RSPO) family members have been shown to drive Wnt-dependent tumor initiation in colorectal cancer (CRC). Therapies targeting Wnt pathway are being actively investigated for tumors harboring RSPO2/3 fusions. Here we set out characterize the molecular features of CRC with and without RSPO gain insight into potential rationale combination therapy strategies. Methods: Tumor DNA sequencing 592 genes (NextSeq, Illumina), RNA 53 gene (ArcherDx...
The treatment scenario of colorectal cancer (CRC) has been evolving in recent years with the introduction novel targeted agents and new therapeutic strategies for metastatic disease. An extensive effort directed to identification predictive biomarkers aid patients selection guide choices. Pharmacogenomics represents an irreplaceable tool individualize based on germline tumor acquired somatic genetic variations able predict drugs response risk toxicities. growing knowledge CRC molecular...
606 Background: Between 3-5% of CRC patients have BRCA1/2 pathogenic mutations. This study aims to identify associations between BRCA1 and BRCA2 mutations clinical characteristics in CRC. Methods: A total 6396 tumor samples were tested with Next-Generation Sequencing (NGS) on a 592-gene panel, or presumed variants counted as (mt). Microsatellite instability (MSI) mutational burden (TMB) by NGS. Statistical correlations investigated using ANOVA, Chi-square t-test. Results: Among tumors...
3600 Background: The SWI/SNF complex includes proteins produced by 29 genes that regulate chromatin structure remodeling through effects upon transcription, replication, and repair. Understanding how gene mutations interact to affect cancer progression could lead new treatment strategies. Methods: We analyzed 7,370 colorectal (CRC) samples with immunohistochemical stains (IHC) Next-Generation Sequencing (NGS) using a 592-gene panel examine the association between of ( ARID1A, ARID2, PBRM1,...
3130 Background: LNs mets are thought to occur before distant mets. However, lymphatic and arise from independent subclones of the primary tumor, suggesting that not essential intermediaries for We aimed comprehensively characterize molecular profile LN explore differences between vs tumors. Methods: Tumor samples CRCs, LNs, were analyzed using NGS (MiSeq on 47 genes, NextSeq 592 genes), immunohistochemistry. mutational burden (TMB) was calculated based somatic nonsynonymous missense...