Derek Muradali

ORCID: 0000-0001-9567-8196
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About
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Research Areas
  • Breast Cancer Treatment Studies
  • Global Cancer Incidence and Screening
  • Breast Lesions and Carcinomas
  • AI in cancer detection
  • Digital Radiography and Breast Imaging
  • BRCA gene mutations in cancer
  • MRI in cancer diagnosis
  • Radiomics and Machine Learning in Medical Imaging
  • Economic and Financial Impacts of Cancer
  • Appendicitis Diagnosis and Management
  • Liver Disease and Transplantation
  • Organ Transplantation Techniques and Outcomes
  • Cancer Risks and Factors
  • Ultrasound Imaging and Elastography
  • Colorectal Cancer Screening and Detection
  • Medical Imaging Techniques and Applications
  • Maternal and fetal healthcare
  • Male Breast Health Studies
  • Cancer Treatment and Pharmacology
  • Ultrasound and Hyperthermia Applications
  • Cancer Diagnosis and Treatment
  • Cancer and Skin Lesions
  • Gallbladder and Bile Duct Disorders
  • Pediatric Hepatobiliary Diseases and Treatments
  • Endometriosis Research and Treatment

University of Toronto
2011-2024

St. Michael's Hospital
2015-2024

Cancer Care Ontario
2013-2019

St Michael's Hospital
2019

3M (United States)
2019

Canada Research Chairs
2015

North York General Hospital
2014

Sunnybrook Health Science Centre
2014

St Michaels Hospital
2011-2013

Princess Margaret Cancer Centre
2011

To characterize blood flow in focal hepatic lesions with harmonic ultrasonographic (US) imaging and a microbubble contrast agent.Thirty patients known masses were examined after injection of perfluorocarbon agent. Tumor vascularity was assessed continuous, gray-scale low mechanical index (MI). vascular volume brief, high-MI insonation called interval-delay imaging, which caused destruction. As the total agent liver reflects volume, quantitation lesion enhancement relative to normal helped...

10.1148/radiology.215.1.r00ap08153 article EN Radiology 2000-04-01

The Ontario Breast Screening Program expanded in July 2011 to screen women age 30 69 years at high risk for breast cancer with annual magnetic resonance imaging (MRI) and digital mammography. To the best of our knowledge, this is first organized screening program cancer.Performance measures after assessment were compared results 2,207 initial examinations. following criteria used determine eligibility: known mutation BRCA1, BRCA2, or other gene predisposing a markedly increased cancer,...

10.1200/jco.2013.52.8331 article EN Journal of Clinical Oncology 2014-06-17

To describe the gray-scale and color duplex Doppler ultrasound (US) magnetic resonance (MR) imaging features of uterine arteriovenous malformations (AVMs).Uterine AVMs in 10 patients were retrospectively evaluated. All underwent US US. Nine angiography with therapeutic embolization; four, MR imaging. The resistance index (RI), pulsatility (PI), peak systolic velocities (PSVs) evaluated.At US, nonspecific manifested as subtle myometrial inhomogeneity, tubular spaces within myometrium,...

10.1148/radiology.206.1.9423660 article EN Radiology 1998-01-01

The Ontario Breast Screening Program expanded in July 2011 to screen high-risk women age 30–69 years with annual magnetic resonance imaging (MRI) and digital mammography. This study examined the benefits of screening mammography MRI by risk criteria. prospective cohort included 8782 referred High Risk from June 2015, final results December 2016. Cancer detection rates, sensitivity, specificity combined were compared each modality individually within groups stratified using generalized...

10.1093/jnci/djz079 article EN JNCI Journal of the National Cancer Institute 2019-04-30

At our institution, ultrasound probes are wiped with a clean, dry, soft, absorbent paper towel after each procedure as basic standard of probe disinfection. However, it was unclear if this provided sufficient level decontamination. This study designed to determine the and coupling gel can act vector nosocomial infection describe cost-effective method handling that allows optimal control infection.In first part study, exposed disrupted skin patients recruited from inpatient population, using...

10.2214/ajr.164.6.7754907 article EN American Journal of Roentgenology 1995-06-01

We report the clinical, microbiological, and radiological features of four cases multifocal osteoarticular tuberculosis, we review management this condition. In each case initial clinical diagnosis was one malignant disease, possibility tuberculous bone infection overlooked. There neither nor evidence pulmonary involvement in any case. Antituberculous chemotherapy initiated two instances on basis histopathologic findings compatible with osteomyelitis; such treatment delayed other until...

10.1093/clinids/17.2.204 article EN Clinical Infectious Diseases 1993-08-01

To evaluate the performance of digital direct radiography (DR) and computed (CR) compared with that screen-film mammography (SFM) in large concurrent cohorts.This study was approved by University Toronto Research Ethics Board did not require informed consent. Concurrent cohorts women aged 50-74 years screened DR (n = 220 520), CR 64 210), or SFM 403 688) between 2008 2009 were identified followed for 12 months. Performance cohorts, as referent cohort. Associations examined using mixed-effect...

10.1148/radiol.13122567 article EN Radiology 2013-05-15

Microcalcifications (MCs) are tiny deposits of calcium in breast soft tissue. Approximately 30% early invasive cancers have fine, granular MCs detectable on mammography; however, their significance tumorigenesis is controversial. This study had two objectives: (1) to find associations between mammographic and tumor pathology, (2) compare the diagnostic value mammograms biopsies identifying malignant MCs. A retrospective chart review was performed for 937 women treated cancer during 2000–2012...

10.1186/s12885-015-1312-z article EN cc-by BMC Cancer 2015-04-21

Background: Classifying papillary lesions of the breast on core biopsy (CB) is challenging. Although traditionally all such were surgically excised, at present, conservative management benign being advocated; therefore, accurately classifying CB more imperative. The extent to which subspecialty training in pathology might mitigate difficulties diagnosis has not yet been reported. We investigated change diagnoses from surgical excision according subspecialist and interobserver agreement...

10.1097/pas.0b013e318243fa00 article EN The American Journal of Surgical Pathology 2012-02-07

Venous outflow problems in right lobe, living-donor liver transplantation are uncommon, but devastating when they occur. We describe the successful use of recipient’s left portal vein as an interposition graft to drain a dominant middle hepatic lobe transplant. Two weeks after transplantation, accounted for 56% total venous liver.

10.1097/00007890-200106270-00028 article EN Transplantation 2001-06-01

Purpose: To compare physical measures pertaining to image quality among digital mammography systems utilized in a large breast screening program. examine qualitatively differences these and clinical cancer detection rates between CR DR sites within that Methods: As part of the routine assurance program for screening, field measurements are made several variables considered correlate with diagnostic medical images including: modulation transfer function, noise equivalent quanta, d′ (an index...

10.1118/1.4829516 article EN Medical Physics 2013-11-27

The aim of this study was to investigate the CT findings and prevalence hepatic subcapsular steatosis in patients undergoing peritoneal dialysis with intraperitoneal insulin delivery.Hepatic appeared as nodules often rindlike areas low attenuation seven (18%) 39 who received their dialysate. Cessation therapy led reversal three patients.

10.2214/ajr.180.6.1801601 article EN American Journal of Roentgenology 2003-06-01

Timely coordinated diagnostic assessment following an abnormal screening mammogram reduces patient anxiety and may optimise breast cancer prognosis. Since 1998, the Ontario Breast Screening Program (OBSP) has offered organised through Assessment Centres (BACs). For OBSP women seen at a BAC, is followed by referrals use of navigators for further imaging, biopsy, surgical consultation as indicated. usual care (UC), imaging arranged directly from centre and/or their physician; results must be...

10.1038/bjc.2017.87 article EN cc-by-nc-sa British Journal of Cancer 2017-03-30

To compare measures of diagnostic accuracy between large concurrent cohorts women screened with digital computed radiography (CR), direct (DR), and screen-film mammography (SFM).This study was approved by the University Toronto Research Ethics Board; informed consent not required. Three aged 50-74 years who were from 2008-2009 in Ontario Breast Screening Program SFM (487,334 screening examinations, 403,688 women), DR (254,758 220,520 or CR (74,140 64,210 women) followed for 2 until breast...

10.1148/radiol.2015150733 article EN Radiology 2015-09-03

To describe the spectrum of ultrasonographic (US) appearances intraluminal gas, including two clinically relevant gas artifacts.Observations were made in patients and reproduced an animal model, ex vivo gut preparation, a tissue-mimicking phantom. Appearances classified according to physical model interaction between sound collections gas.Free bubbles appeared as bright echogenic foci extending artifactually owing lateral axial blooming. This causes that abut wall enhance layer one echo,...

10.1148/radiology.210.1.r99ja12113 article EN Radiology 1999-01-01

Failure to reveal pneumoperitoneum is a recognized weakness of abdominal sonography. Our objective describe reliable and reproducible sign that was first identified in an animal model then confirmed patients who had undergone laparoscopy.We injected 300 ml degassed water into the peritoneal cavity 15-kg anesthetized pig. Sonographic images were obtained anterior area after intraperitoneal injection single bubble, series bubbles, and, subsequently, 10-ml bolus air. Later, sonography performed...

10.2214/ajr.173.5.10541100 article EN American Journal of Roentgenology 1999-11-01

The purpose of this study was to describe the sonographic appearance and histopathologic basis those malignancies breast that show non-enhancement on MRI.Breast with suspicious features sonography may not be detected MRI due lesions. In such cases, we suggest use tissue sampling differentiate between benign malignant

10.2214/ajr.185.2.01850481 article EN American Journal of Roentgenology 2005-08-01

Background: The use of preoperative breast magnetic resonance imaging (MRI) after the diagnosis cancer by mammography and/or ultrasound is inconsistent. Methods: After conducting a systematic review and meta-analysis comparing MRI versus no MRI, we reconvened to prepare clinical practice guideline on this topic. Results: Based evidence that improved recurrence, decreased rates reoperations (re-excisions or conversion mastectomy), increased detection synchronous contralateral cancer,...

10.3390/curroncol30070463 article EN cc-by Current Oncology 2023-06-30

A multicenter placebo-controlled trial of early short-term high-dose methylprednisolone enrolled 78 patients with moderate to severe Pneumocystis carinii pneumonia (PCP) complicating HIV infection. The mean pressure oxygen (PO2) at study entry was 55 mm Hg for the 71 who had blood gases monitored while breathing room air. Patients were randomized receive (40 mg) or placebo parenterally twice daily 10 days, and first dose medication given within 24 h antimicrobial therapy PCP. primary end...

10.1097/00042560-199504000-00005 article EN Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 1995-04-01
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