A5075349555- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Cancer survivorship and care
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Tumor Detection and Classification
- Advanced X-ray and CT Imaging
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- Radiation Therapy and Dosimetry
- Lymphoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer-related cognitive impairment studies
- Neuroblastoma Research and Treatments
- Cancer Diagnosis and Treatment
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Università Cattolica del Sacro Cuore
2012-2024
University of the Sacred Heart
2024
Ospedaliera di Piacenza
2021-2023
Azienda Unità Sanitaria Locale Piacenza
2023
University Health Network
2022
Great Ormond Street Hospital for Children NHS Foundation Trust
2022
Guglielmo da Saliceto Hospital
2022
University of California, Irvine
2022
The survival benefit in maximizing resection glioblastomas (GBMs) has been demonstrated by numerous studies. true limit of infiltration GBMs an overwhelming obstacle, and several technological advances have introduced to improve the identification residual tumors.To evaluate whether integration 5-aminolevulinic acid (5-ALA) with microbubble contrast-enhanced ultrasound (CEUS) improves tumor impact on extent (EOR), overall (OS), progression-free (PFS).A total 230 GBM procedures were...
In the randomized phase II REGOMA trial, regorafenib showed promising activity in patients with recurrent glioblastoma. We conducted a large, multicenter, prospective, observational study to confirm data real-world setting.
Background and purpose. Anatomic changes during head neck radiotherapy require replanning. The primary aim of this study is the definition agreement among experts in automatic delineation frame to use as benchmark. secondary goal assess reliability for nasopharynx time saving. Material methods. A computed tomography (CT) scan was acquired 10 patients along intensity-modulated (IMRT) treatment Deformable registration with replanning autocontouring structures performed using VelocityAI 2.3©...
In a previous preliminary study, radiomic features from the largest and hottest lesion in baseline 18F-FDG PET/CT (bPET/CT) of classical Hodgkin's Lymphoma (cHL) predicted early response-to-treatment prognosis. Aim this large retrospectively-validated study is to evaluate predictive role two-lesions radiomics comparison with other clinical conventional models. cHL patients bPET/CT between 2010 2020 were retrospectively included randomized into training-validation sets. Target lesions were:...
Abstract Purpose Neuro-oncology is a multidisciplinary subspecialty that has evolved and expanded tremendously over the last 20 years. In Europe, notwithstanding number of commendable initiatives, neither specific neuro-oncology training curriculum nor consensus on ideal tools have been set. this context, Youngster Committee Italian Association for Neuro-Oncology (AINO) run nationwide survey to take snapshot current situation education in Italy. Methods Between July November 2023, we...
We explored the feasibility of concurrent palliative chemotherapy and low-dose fractionated radiotherapy (LD-FRT) in glioblastoma multiforme (GBM). Patients with recurrent/progressive GBM at least 3 months after end primary received 0.3 Gy twice daily cisplatin fotemustine if progressing on temozolomide, or 0.4 temozolomide recurrent 4-6 later (retreatment group). Newly diagnosed gross residual mass 30 concomitant adjuvant from second cycle (naive group) for 2-4 cycles. Twenty-six patients...
Age is an unfavorable prognostic factor in glioblastoma multiforme (GBM). To assess the possibility and advantage of radiotherapy (RT) plus concomitant/sequential temozolomide (TMZ) patients over 65 years with GBM, we analyzed 4 prospective trials terms compliance outcomes.Elderly histologically proven included phase II studies a Karnofsky Performance Status (KPS) >70 Charlson Comorbidity Index (CCI) <3, were selected for these analyses. Patients treated by 3D-conformal RT (60 Gy),...
The multi-disciplinary tumor board (MTB) is essential to quality cancer care and currently recommended offer the best personalized clinical approach, but little has been published regarding MTBs in neuro-oncology (nMTBs). aim of present paper describe our nMTB, evaluate its impact on management decisions, assess role neuroradiologists.The retrospective evaluation cases discussed at nMTB from March 2017 2020. From electronic records, we extracted epidemiological, other specific data nMTB....
The aim of this study is to test a novel multiparametric imaging guided procedure for high-dose-rate brachytherapy in anal canal cancer, order evaluate the feasibility and safety.For analysis, we considered all consecutive patients who underwent magnetic resonance/computed tomography image adapted (MR/CT-IABT) treated from February 2012 July 2014. To conduct project, formed working group that established identified indicators benchmarks safety. We acceptable if 90% were consistent with...
Abstract Background Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In previous exploratory study patients bipolar I disorder, we found that history suicide attempts was differences between winter summer levels solar insolation. The purpose this to confirm finding using international data from 42% more collection sites 25% countries. Methods Data analyzed were 71 prior new in 40 countries at wide range latitudes. analysis included 4876 45% than...
Abstract In research and clinical contexts, it is important to briefly evaluate perceived Psychological Social Support (PSS) plan psychological interventions allocate efforts resources. However, an appropriate brief assessment tool for PSS was lacking. This study aimed at developing a accurate scale specifically measure in emergency with specific, relevant, targeted, irredundant items. Experienced clinicians developed the Psycho-Social Scale (PSSS) administered sample (N = 112) seeking help...
Background: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment. Several other therapeutic strategies have been attempted in last years without significant effect on OS. Although radiological imaging gold standard for DIPG diagnosis, urgent need to improve has led reconsideration biopsy aim better understand molecular profile and support personalized...
Decades of therapeutic and molecular refinements, the prognosis patients with glioblastoma (GBM) still remains unfavorable. Integrative clinical studies allow a better understanding natural evolution GBM. To assess independent predictors overall survival (OS) progression free (PFS) clinical, surgical, radiological variables were evaluated. A novel preoperative volumetric magnetic resonance imaging (MRI) Index for tumor in GBM was investigated.A cohort 195 cases operated newly analyzed....
Abstract Predictive factors for response to regorafenib in recurrent glioblastoma, IDH- wildtype, are scarcely recognized. The objective of this study was identify molecular predictive using a clinically available platform. We analyzed prospective cohort 30 patients harboring and treated with regorafenib. Next-generation sequencing (NGS) analysis performed on DNA extracted from paraffin-embedded tissues Moreover, MGMT methylation EGFRvIII expression analyses were performed. Six-month...