A5048766102- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Advanced X-ray and CT Imaging
- Autoimmune Neurological Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Viral-associated cancers and disorders
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- AI in cancer detection
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Radiotherapy Techniques
- Oral and Maxillofacial Pathology
- Medical Image Segmentation Techniques
Université de Reims Champagne-Ardenne
2016-2025
Agostino Gemelli University Polyclinic
2022-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2025
Institut Jean Godinot
2016-2024
Centre de Recherche en Sciences et Technologies de l'Information et de la Communication
2016-2024
Centre for Research in Engineering Surface Technology
2019-2023
Centre de Recherche en Économie et Statistique
2018-2021
Centre d'Excellence en Technologies de l'Information et de la Communication
2016-2021
Centre de Médecine Préventive
2019-2020
Piramal (Germany)
2017
A mesenteric mass (MM), characterized by fibrotic reaction, is present in most small-intestinal neuroendocrine tumors (SI-NETs). <sup>177</sup>Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) has shown its efficacy patients with progressive SI-NETs. However, because of specific tissue characteristics desmoplastic MMs, we hypothesize that these lesions may be refractory to PRRT. <b>Methods:</b> From the national French Groupe d'étude des Tumeurs Endocrines database, identified an...
In a previous preliminary study, radiomic features from the largest and hottest lesion in baseline 18F-FDG PET/CT (bPET/CT) of classical Hodgkin's Lymphoma (cHL) predicted early response-to-treatment prognosis. Aim this large retrospectively-validated study is to evaluate predictive role two-lesions radiomics comparison with other clinical conventional models. cHL patients bPET/CT between 2010 2020 were retrospectively included randomized into training-validation sets. Target lesions were:...
This paper provides a set of guidelines for the design software interfaces video terminals. It describes how to optimize screen layouts, interactive data entry, and error handling, as well many practical techniques improving man-machine interaction. Emphasis is placed on factors relating perceptual cognitive psychology rather than gross physiological concerns. Ways in which can be evaluated improve their user friendliness are also suggested. The author summarizes ideas that found other, more...
Patients (pts) with asymptomatic low-burden follicular lymphoma (FL) are usually observed at diagnosis. Time to treatment (TLT) initiation can however be very heterogeneous and risk factors of progression poorly studied. Our study evaluated 201 pts grade 1-3a low-tumor burden FL diagnosed in four French centers between 2010 2020 managed by a watch wait strategy real-life settings. After median follow-up 4.8 years, the TLT was 4.2 years (95% confidence interval, 3.1-5.5). On multivariate...
This study investigated the predictive role of baseline 18F-FDG PET/CT (bPET/CT) radiomics from two distinct target lesions in patients with classical Hodgkin’s lymphoma (cHL). cHL examined bPET/CT and interim between 2010 2019 were retrospectively included. Two selected for radiomic feature extraction: Lesion_A, largest axial diameter, Lesion_B, highest SUVmax. Deauville score at (DS) 24-month progression-free-survival (PFS) recorded. Mann–Whitney test identified most promising image...
A 70-year-old man with prostate cancer and increased prostate-specific antigen level of 55 ng/mL underwent staging F-fluorocholine PET/CT, which demonstrated the primary tumor a focal area corresponding to 2-cm hypodense nodule in left thyroid lobe. Fine-needle aspiration subsequent total thyroidectomy central lymph node dissection showed an oxyphilic papillary carcinoma medullary microcarcinoma. Oxyphilic tumors represent significant proportion few case reports incidental fluorocholine uptake.
Abstract Hyperparathyroidism is a common endocrine disorder. The precise localization of causal parathyroid gland crucial to guide surgical treatment. Several studies report the added value 18F-fluorocholine (FCH) positron emission tomography-computed tomography (PET/CT) as second line imaging but rely on suboptimal first-line using 99mTc-sestaMIBI dual phase scintigraphy. aim this study evaluate percentage successful with FCH PET/CT after failure more sensitive detection protocol...
We present the case of a 53-year-old woman presenting several episodes body image distortions, ground deformation illusions, and problems assessing distance in orthostatic position corresponding to Alice Wonderland syndrome. No symptoms were reported when sitting or lying down. She had uncontrolled hypertension, hyperglycemia, hypercholesterolemia, history head trauma. Her condition been diagnosed with left internal carotid artery dissection 2 years earlier. Brain SPECT 99mTc-ECD performed...
PET/CT with 6-18F-fluoro-l-dopa (18F-FDOPA) has high diagnostic performance for midgut neuroendocrine tumors (NETs). We explored the prognostic role of 18F-FDOPA uptake in metastatic NETs. Methods: included, a test cohort (n = 166) and full external validation 86), all consecutive patients NETs who underwent 5 expert centers from 2010 to 2021. measured maximal (SUVmax SUVpeak) tumor nontumor liver on each scan. overall survival (OS) time assessed factors using Kaplan-Meier multivariable Cox...
We report the case of a 28-year-old woman presenting behavior disorders subacute onset. She was referred in our institution for suspicion limbic encephalitis. F-FDG PET/CT did not show any mesiotemporal abnormality but depicted decreased uptake bilateral parietal and occipital lobes. This atypical pattern compatible with an anti-N-methyl-D-aspartate receptor encephalitis that later confirmed.
Optimal scan time of F-fluorocholine (FCH) PET/CT for localization hyperfunctioning parathyroid glands is poorly documented. We report a small series 9 histologically proven gland with heterogeneous temporal uptake profile. Thirty-minute dynamic acquisition starting just after administration and delayed were recorded. Three different patterns are seen (early washout, stable uptake, late increase) indicating the importance an early (5-10 minutes) acquisition. A (60 could be useful when...
A 53-year-old woman presented with a 3-month history of left inguinocrural and lumbar pain anorexia weight loss. No fever was reported. The patient had no prior pelvic surgery. Physical examination revealed palpable nontender mass in the groin area. There bloody or purulent discharge. Laboratory findings inflammation an increased C-reactive protein level (127 mg/L [1209 nmol/L]), leukocytosis (13 800/mm(3)), microcytic anemia (hemoglobin level, 7.2 g/dL). Computed tomography (CT), fluorine...
A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed mild focal uptake in the projection right thyroid lobe negative ultrasonography. F-Fluorocholine PET/CT quickly performed considering this discrepancy not only confirmed scintigraphic findings but also revealed second contralateral focus...
Purpose Peritoneal carcinomatosis (PC) concerns up to 30% of patients with a neuroendocrine tumor (NET), especially the small intestine. Aggressive management seems be justified, regard possible mechanical complications. 18 F-FDOPA PET/CT is known most sensitive imaging modality for detection bowel NET metastases, yet its performance in PC not well studied. The main objective our study evaluate performances preoperative prediction surgical peritoneal cancer index. Methods All referred center...
Accurate tumor volume delineation is a crucial step for disease assessment, treatment planning and monitoring of several kinds cancers. However, this process complex due to variations in tumors properties. Recently, some methods have been proposed taking advantage the spatial spectral information carried by coupled modalities (e.g., PET-CT, MRI-PET). Simultaneously, development attributebased approaches has contributed improve PET image analysis. In work, we aim at developing multimodal /...
We report the case of a 69-year-old man referred for F-fluorocholine (FCH) PET/CT biochemical recurrence prostate cancer. FCH demonstrated 2 hypodense hepatic lesions with no uptake but progressing in size compared previous assessment. MRI showed suspicious peripheral contrast enhancement, raising question liver metastasis. Histopathologic examination concluded to adenocarcinoma This highlights an unusual pitfall PET/CT: lack prostatic metastasis is presumably due partial volume effect...
Healthy organs uptake, including cerebellar and liver SUVs have been reported to be inversely correlated total metabolic tumor volume (TMTV), a controversial predictor of event-free survival (EFS) in classical Hodgkin's Lymphoma (cHL). The objective this study was estimate TMTV by using healthy SUV measurements assess the performance new index (UF, Uptake Formula) predict EFS cHL.Patients with cHL were retrospectively included. values derived from baseline 18F-FDG PET/CT harmonized ComBat...