Irene Aprile

ORCID: 0000-0001-8123-9977
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About
Contact & Profiles
Research Areas
  • Stroke Rehabilitation and Recovery
  • Peripheral Nerve Disorders
  • Botulinum Toxin and Related Neurological Disorders
  • Cerebral Palsy and Movement Disorders
  • Acute Ischemic Stroke Management
  • Orthopedic Surgery and Rehabilitation
  • Balance, Gait, and Falls Prevention
  • Nerve Injury and Rehabilitation
  • Peripheral Neuropathies and Disorders
  • Musculoskeletal pain and rehabilitation
  • Muscle activation and electromyography studies
  • Parkinson's Disease Mechanisms and Treatments
  • Hereditary Neurological Disorders
  • Pain Mechanisms and Treatments
  • EEG and Brain-Computer Interfaces
  • Nutrition and Health in Aging
  • Myasthenia Gravis and Thymoma
  • Telemedicine and Telehealth Implementation
  • Prosthetics and Rehabilitation Robotics
  • Muscle Physiology and Disorders
  • Transcranial Magnetic Stimulation Studies
  • Motor Control and Adaptation
  • Neuroscience and Neural Engineering
  • Genetic Neurodegenerative Diseases
  • Spine and Intervertebral Disc Pathology

Don Carlo Gnocchi Foundation
2016-2025

International Flame Research Foundation
2008-2025

University of Pavia
2024

Istituti di Ricovero e Cura a Carattere Scientifico
2002-2023

Università Cattolica del Sacro Cuore
2002-2019

iRobot (United States)
2019

Scuola Superiore Sant'Anna
2019

Molina Center for Energy and the Environment
2008

Neuroscience Institute
2004-2006

Fondazione Roma
2003-2006

To assess the course of untreated carpal tunnel syndrome (CTS).The Italian CTS Study Group prospectively followed up (10 to 15 months) 196 patients (274 hands) with idiopathic multiple measurements CTS. Baseline factors were used predict evolution in regression analysis.Comparison baseline and follow-up data showed a significant spontaneous improvement patient-oriented neurophysiologic measurements. A correlation between initial severity was observed. improved more severe impairment whereas...

10.1212/wnl.56.11.1459 article EN Neurology 2001-06-12

After stroke, only 12% of survivors obtain complete upper limb (UL) functional recovery, while in 30% to 60% UL deficits persist. Despite the complexity UL, prior robot-mediated therapy research has used one robot comparisons conventional therapy. We evaluated efficacy robotic treatment using a set 4 devices, compared with therapy.In multicenter, randomized controlled trial, 247 subjects subacute stroke were assigned either (using devices) or treatment, each consisting 30 sessions. Subjects...

10.1097/npt.0000000000000295 article EN Journal of Neurologic Physical Therapy 2019-12-11

Abstract The adult somatosensory system has shown reorganizational abilities at cortical and subcortical levels after peripheral nerve lesions. In the present study effects of carpal tunnel syndrome (CTS) are investigated as reflected on somatotopy primary hand representation. Position intensity sources activated by separate electrical stimulation median Digits 1, 3, 5 both affected non‐affected hands evaluated magnetoencephalographic (MEG) technique. Correlation MEG results with patient‐,...

10.1002/hbm.10049 article EN Human Brain Mapping 2002-07-19

<b><i>Objective:</i></b> To assess the clinical and neurophysiologic dissociation often observed in practice, to improve patient evaluation for diagnosis of carpal tunnel syndrome (CTS). <b><i>Methods:</i></b> The Italian CTS Study Group studied 1,123 idiopathic hands with multiple measurements—clinical, neurophysiologic, patient-oriented—of CTS. <b><i>Results:</i></b> Clinical relationships were very strong when picture was evaluated by hand functional measurements, an exponential increase...

10.1212/wnl.53.8.1654 article EN Neurology 1999-11-01

Abstract Background The majority of stroke survivors experiences significant hand impairments, as weakness and spasticity, with a severe impact on the activity daily living. To objectively evaluate deficits, quantitative measures are needed. aim this study is to assess reliability, validity discriminant ability instrumental provided by robotic device for rehabilitation, in sample patients subacute stroke. Material methods In study, 120 40 controls were enrolled. Clinical evaluation included...

10.1186/s12984-019-0634-5 article EN cc-by Journal of NeuroEngineering and Rehabilitation 2020-01-03

The aim of this study was to assess quality life (QoL) and evaluate the occurrence characteristics pain in facioscapulohumeral muscular dystrophy (FSHD) patients. No has yet assessed QoL a large group FSHD patients and, overall, few studies have neuromuscular diseases. We performed prospective using multidimensional protocol including: clinical (according Clinical Severity Scale Rev1); genetic (p13E-11 EcoRI fragments (Short Form-36); (Visual Analog Portenoy-6 questions); depression (Beck...

10.1002/mus.21308 article EN Muscle & Nerve 2009-07-16

Advanced rehabilitation strategies of the upper limb in stroke patients focus on recovery most important daily activities. In this study we analyzed quantitatively and qualitatively motor employed by when reaching drinking from a glass. We enrolled 6 hemiparetic poststroke healthy subjects. Motion analysis task proposed (reaching for glass, bringing it to mouth, putting back table) with affected was performed. Clinical assessment using Fugl-Meyer Assessment Upper Extremity also included....

10.1155/2014/636123 article EN cc-by BioMed Research International 2014-01-01

In the last few years, there has been an increasing interest in use of robotic devices to objectively quantify motor performance patients after brain damage. Although these robot-derived measures can potentially add meaningful information about patient's dexterity, as well be used outcome measurements rehabilitation treatment, they need validated before being clinical practice. The present work aims evaluate reliability, validity and discriminant ability metrics provided by a novel device...

10.1186/s12984-018-0385-8 article EN cc-by Journal of NeuroEngineering and Rehabilitation 2018-05-16

Although stroke survivors can benefit from robotic gait rehabilitation, stationary robot-assisted training needs further investigation. In this paper, we investigated the efficacy of approach (with an exoskeleton or end-effector robot) in comparison to conventional overground subacute survivors.In a multicenter controlled clinical trial, 89 conducted twenty sessions (Robotic Group) (Control addition standard daily therapy. The was performed with (RobotEXO-group) (RobotEND-group). Clinical...

10.3390/jcm12020439 article EN Journal of Clinical Medicine 2023-01-05

Robotic rehabilitation of the upper limb has demonstrated promising results in terms improvement arm function post-stroke patients. The current literature suggests that robot-assisted therapy (RAT) is comparable to traditional approaches when clinical scales are used as outcome measures. Instead, effects RAT on capacity execute a daily life task with affected unknown, measured using kinematic indices. Through analysis drinking task, we examined performance between patients following robotic...

10.3390/s23063089 article EN cc-by Sensors 2023-03-13

Context Chronic Neurological Disorders (CNDs) are among the leading causes of disability worldwide, and their contribution to overall need for rehabilitation is increasing. Therefore, identification new digital solutions ensure early continuous care mandatory. Objective This protocol proposes test usability, acceptability, safety, efficacy Telerehabilitation (TR) protocols with robotic tools in reducing perceived level CNDs including Parkinson's Disease (PD), Multiple Sclerosis (MS),...

10.1177/20552076241228928 article EN cc-by-nc-nd Digital Health 2024-01-01

Bioelectrical Impedance Vector Analysis (BIVA) is a valuable tool for evaluating hydration and body composition, but its application in subacute post-stroke patients remains unexplored. This study aimed to fill this gap by analyzing BIVA cohort of 87 (42 women, mean age 69 ± 12) undergoing rehabilitation. At admission (T0), diagnosis malnutrition with GLIM criteria sarcopenia EWGSOP2 was done, were analyzed BIVA. The change modified Barthel Index (mBIT1-mBIT0) assessed evaluate the...

10.1038/s41598-024-84968-y article EN cc-by-nc-nd Scientific Reports 2025-01-13

ABSTRACT Full thickness thoraco‐abdominal defects are traditionally challenging to reconstruct, exposing the patient a significant risk of wound complications and functional impairment. The authors present an extremely unique case where huge lateral defect was reconstructed with combination innervated flaps allowing completely restore contour function operated region. A 77‐year‐old male presented leiomyosarcoma arising in right Full‐thickness resection involved anterior part latissimus dorsi...

10.1002/micr.70038 article EN cc-by Microsurgery 2025-02-01

Parkinson’s disease (PD) and multiple sclerosis (MS) are two chronic neurological diseases (CNDs) that have a high demand for early continuous rehabilitation. However, accessing professional care remains challenge, making it key priority to identify sustainable solutions ensuring rehabilitation availability. Objective: The FIT4TeleNEURO pragmatic trial proposes investigate, in real-life settings, the superiority terms of effectiveness intervention with harmonized, mix-model...

10.3390/healthcare13060682 article EN Healthcare 2025-03-20
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