A5049987083- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- PARP inhibition in cancer therapy
- Gut microbiota and health
- Ovarian cancer diagnosis and treatment
- Bioinformatics and Genomic Networks
- Mental Health Research Topics
- Endometrial and Cervical Cancer Treatments
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Renal function and acid-base balance
- Cerebral Palsy and Movement Disorders
- Nutritional Studies and Diet
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Pediatric Hepatobiliary Diseases and Treatments
- Balance, Gait, and Falls Prevention
- Breast Lesions and Carcinomas
- AI in cancer detection
- Digital Radiography and Breast Imaging
- Drug Transport and Resistance Mechanisms
- Cutaneous Melanoma Detection and Management
- Thyroid Cancer Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
King's College London
2023-2025
St Thomas' Hospital
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2023
Mario Negri Institute for Pharmacological Research
2017-2022
Humanitas University
2021-2022
The optimal dietary pattern to improve metabolic function remains elusive. In a 21-day randomized controlled inpatient crossover feeding trial of 20 insulin-resistant obese women, we assessed the extent which two isocaloric interventions—Mediterranean (M) and high protein (HP)—improved parameters. Obese women were assigned one following sequences: M–HP or HP–M. Cardiometabolic parameters, body weight, glucose monitoring gut microbiome composition assessed. Sixteen completed study. Compared M...
isoUDCA are determined by the gut microbiome d levels associate with higher post-prandial lipemia and fasting appetite Higher correlate worse liver function enzyme values decrease post-bariatric surgery after fiber supplementation
Chronic kidney disease (CKD) is a major public health burden, with dietary acid load (DAL) and gut microbiota playing crucial roles. As DAL can affect the host metabolome, potentially via microbiota, we cross-sectionally investigated interplay between DAL, early-stage CKD (TwinsUK, n = 1,453). was positively associated stage G1-G2 (Beta (95% confidence interval) 0.34 (0.007; 0.7), p 0.046). After adjusting for covariates multiple testing, identified 15 serum, 14 urine, 8 stool, 7 saliva...
High-throughput omics technologies have revolutionised the identification of associations between individual traits and underlying biological characteristics, but still use 'one effect-size fits all' approaches. While covariates are often used, their potential as effect modifiers remains unexplored. We propose ESPClust, a novel unsupervised method designed to identify that modify size sets variables outcomes. By extending concept moderators encompass multiple exposures, ESPClust analyses...
Prediabetes is a metabolic condition associated with gut microbiome composition, although mechanisms remain elusive. We searched for fecal metabolites, readout of function, impaired fasting glucose (IFG) in 142 individuals IFG and 1,105 healthy from the UK Adult Twin Registry (TwinsUK). used Cooperative Health Research Region Augsburg (KORA) cohort (318 individuals, 689 individuals) to replicate our findings. linearly combined eight IFG-positively metabolites (1-methylxantine, nicotinate,...
TPS5608 Background: Prognosis of advanced/recurrent endometrial cancer (EC) is poor with median survival 12-15 months for patients measurable disease. Treatment options are limited, primary management being chemotherapy carboplatin and paclitaxel. EC known to be one the tumor types highest mutational load. Ultra- hyper-mutated EC, which harbor POLE mismatch repair gene defects respectively, have shown peri-tumoral T cell infiltration high expression PD-1 PD-L1 proteins, suggesting that...
Abstract High-throughput omics technologies have revolutionised the identification of associations between individual traits and underlying biological characteristics, but still use ‘one effect-size fits all’ approaches. While covariates are often used, their potential as effect modifiers remains unexplored. To bridge this gap, we introduce ESPClust, a novel unsupervised method designed to identify that modify size sets variables outcomes. By extending concept moderators encompass multiple...
To evaluate the performance, quality and effectiveness of "IEO-TIRADS" in assigning a TI-RADS score to thyroid nodules (TN) when compared with "EU-TIRADS" US risk calculated S-Detect software ("S-Detect"). The primary objective is evaluation diagnostic accuracy (DA) by "IEO-TIRADS", "S-Detect" "EU-TIRADS", secondary performances scores, using histological report as gold standard. A radiologist collected all three scores TNs detected determined malignancy. results were specimens. sensitivity...
<p dir="ltr">Prediabetes is a metabolic condition associated with gut microbiome composition, though mechanisms remain elusive. We searched for faecal metabolites, readout of function, impaired fasting glucose (IFG) in 142 individuals IFG and 1105 healthy from TwinsUK. used the KORA cohort (318 individuals, 689 individuals) to replicate our findings. linearly combined 8 IFG-positively metabolites (1-methylxantine, nicotinate, glucuronate, uridine, cholesterol, serine, caffeine...
<p dir="ltr">Prediabetes is a metabolic condition associated with gut microbiome composition, though mechanisms remain elusive. We searched for faecal metabolites, readout of function, impaired fasting glucose (IFG) in 142 individuals IFG and 1105 healthy from TwinsUK. used the KORA cohort (318 individuals, 689 individuals) to replicate our findings. linearly combined 8 IFG-positively metabolites (1-methylxantine, nicotinate, glucuronate, uridine, cholesterol, serine, caffeine...