A5054248333- Diet and metabolism studies
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Nuts composition and effects
- Gut microbiota and health
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Dietary Effects on Health
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- COVID-19 and Mental Health
- Food composition and properties
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Muscle metabolism and nutrition
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Menopause: Health Impacts and Treatments
- Bee Products Chemical Analysis
- Food Chemistry and Fat Analysis
- Nutrition and Health in Aging
King's College London
2016-2025
ZOE (United Kingdom)
2024
King's College - North Carolina
2020-2022
Crohn's and Colitis UK
2021-2022
Royal Jubilee Maternity Services
2021
University of Cambridge
2020
Baylor College of Medicine
2017
University of Messina
2014
Norwich Research Park
2014
Quadram Institute
2014
Abstract Metagenomic assembly enables new organism discovery from microbial communities, but it can only capture few abundant organisms most metagenomes. Here we present MetaPhlAn 4, which integrates information metagenome assemblies and isolate genomes for more comprehensive metagenomic taxonomic profiling. From a curated collection of 1.01 M prokaryotic reference metagenome-assembled genomes, define unique marker genes 26,970 species-level genome bins, 4,992 them taxonomically unidentified...
COVID-19 vaccines show excellent efficacy in clinical trials and effectiveness real-world data, but some people still become infected with SARS-CoV-2 after vaccination. This study aimed to identify risk factors for post-vaccination infection describe the characteristics of illness.
Poor metabolic health and unhealthy lifestyle factors have been associated with risk severity of COVID-19, but data for diet are lacking. We aimed to investigate the association quality COVID-19 its interaction socioeconomic deprivation.
Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary were less likely test positive for infection.
Gut transit time is a key modulator of host-microbiome interactions, yet this often overlooked, partly because reliable methods are typically expensive or burdensome. The aim single-arm, single-blinded intervention study to assess (1) the relationship between gut and human microbiome, (2) utility 'blue dye' method as an inexpensive scalable technique measure time.We assessed interactions taxonomic functional potential profiles microbiome (profiled via shotgun metagenomic sequencing),...
Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in diet-health axis, but while its bacterial fraction widely studied, role micro-eukaryotes, including Blastocystis, underexplored. We performed global-scale analysis on 56,989 metagenomes showed that Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, dietary habits. presence defined specific signature was positively...
Large variability exists in people's responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a program (PDP) versus general (control) on cardiometabolic using randomized clinical trial. The PDP used food characteristics, individual postprandial glucose and triglyceride (TG) foods, microbiomes history, produce scores an 18-week app-based program. control group received standard care (US Department Agriculture Guidelines Americans,...
Abstract As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little known about diet-pattern-specific metagenomic profiles across populations. Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences diet pattern (omnivore, vegetarian and vegan) are reflected microbiomes. Microbial distinguished these common patterns well (mean AUC = 0.85). Red meat was a strong driver of omnivore...
Cereal crops, particularly wheat, are a major dietary source of starch, and the bioaccessibility starch has implications for postprandial glycemia. The structure properties plant foods have been identified as critical factors in influencing nutrient bioaccessibility; however, physical biochemical disassembly cereal food during digestion not widely studied.The aims this study were to compare effects 2 porridge meals prepared from wheat endosperm with different degrees on metabolism (e.g.,...
Background: The particle size and structure of masticated almonds have a significant impact on nutrient release (bioaccessibility) digestion kinetics. Objectives: goals this study were to quantify the effects mastication bioaccessibility intracellular lipid almond tissue examine microstructural characteristics almonds. Design: In randomized, subject-blind, crossover trial, 17 healthy subjects chewed natural (NAs) or roasted (RAs) in 4 separate sessions. Particle distributions (PSDs)...
SummaryBackgroundSelf-reported symptoms during the COVID-19 pandemic have been used to train artificial intelligence models identify possible infection foci. To date, these only considered culmination or peak of symptoms, which is not suitable for early detection infection. We aimed estimate probability an individual being infected with SARS-CoV-2 on basis self-reported enable timely self-isolation and urgent testing.MethodsIn this large-scale, prospective, epidemiological surveillance...
Abstract Metagenomic assembly enables novel organism discovery from microbial communities, but most metagenomes it can only capture few abundant organisms. Here, we present a method - MetaPhlAn 4 to integrate information both metagenome assemblies and isolate genomes for improved more comprehensive metagenomic taxonomic profiling. From curated collection of 1.01M prokaryotic reference metagenome-assembled genomes, defined unique marker genes 26,970 species-level genome bins, 4,992 them...
Racial/ethnic minorities have been disproportionately impacted by COVID-19. The effects of COVID-19 on the long-term mental health remains unclear. To evaluate differences in odds screening positive for depression and anxiety among various racial ethnic groups during latter phase pandemic, we performed a cross-sectional analysis 691,473 participants nested within prospective smartphone-based COVID Symptom Study United States (U.S.) Kingdom (U.K). from February 23, 2021 to June 9, 2021. In...
Abstract Although diet is a substantial determinant of the human gut microbiome, interplay between specific foods and microbial community structure remains poorly understood. Coffee habitually consumed beverage with established metabolic health benefits. We previously found that coffee is, among >150 items, food showing highest correlation microbiome components. Here we conducted multi-cohort, multi-omic analysis US UK populations detailed dietary information from total 22,867...
Plant cell walls are known to influence the rate and extent of lipid release from plant food tissues during digestion; however, effect wall structure on postprandial lipemia is unknown.The objective was investigate effects (bioaccessibility) by comparing encapsulated with present as free oil.A randomized crossover trial (n = 20 men) compared 3 meals containing 54 g fat provided whole almond seed macroparticles (WA), oil defatted flour (AO), or a sunflower blend control (CO) changes in...
K-rich fruit and vegetables may lower blood pressure (BP) improve vascular function. A randomised controlled trial (ISRCTN50011192) with a cross-over design was conducted in free-living participants early stages of hypertension (diastolic BP>80 < 100 mmHg, not receiving BP-lowering medication) to test this hypothesis. Following 3-week run-in period on control diet, each subject completed four dietary 6-week interventions (control+placebo capsules, an additional 20 or 40 mmol K + /d...