A5088954452- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Nutritional Studies and Diet
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Bladder and Urothelial Cancer Treatments
- Polyomavirus and related diseases
- Fatty Acid Research and Health
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- Microbial Metabolism and Applications
- Vitamin D Research Studies
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Adipokines, Inflammation, and Metabolic Diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- Enterobacteriaceae and Cronobacter Research
- Immune cells in cancer
- Coffee research and impacts
- Antifungal resistance and susceptibility
European Institute of Oncology
2022-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
University of Trento
2023
Patient responses to immune checkpoint inhibitors can be influenced by the gastrointestinal microbiome. Mouse models used study microbiome–host crosstalk, yet their utility is constrained substantial anatomical, functional, immunological and microbial differences between mice humans. Here we show that a gut-on-a-chip system mimicking architecture functionality of human intestine including faecal microbiome peristaltic-like movements recapitulates interactions predicts in patients with...
CD8+ T cells are a major prognostic determinant in solid tumors, including colorectal cancer (CRC). However, understanding how the interplay between different immune impacts on clinical outcome is still its infancy. Here, we describe that interaction of tumor infiltrating neutrophils expressing high levels CD15 with effector memory (TEM) correlates progression. Mechanistically, stromal cell-derived factor-1 (CXCL12/SDF-1) promotes retention within increasing crosstalk cells. As consequence...
Abstract Although diet is a substantial determinant of the human gut microbiome, interplay between specific foods and microbial community structure remains poorly understood. Coffee habitually consumed beverage with established metabolic health benefits. We previously found that coffee is, among >150 items, food showing highest correlation microbiome components. Here we conducted multi-cohort, multi-omic analysis US UK populations detailed dietary information from total 22,867...
Several studies suggest a role of gut microbiota in colorectal cancer (CRC) initiation and progression. Vitamin D (vitD) blood levels are also inversely correlated with CRC risk prognosis. However, these factors' interplay remains unknown.
Immune checkpoint inhibitors (ICIs) improve outcomes in advanced melanoma, but many patients are refractory or experience relapse. The gut microbiota modulates antitumor responses. However, inconsistent baseline predictors point to heterogeneity responses and inadequacy of cross-sectional data. We followed with unresectable melanoma from during anti-PD-1 therapy, collecting fecal blood samples that were surveyed for changes the immune markers. Varying patient linked different dynamics ICI...
A recent metagenomic survey has revealed an unknown bacterial clade within the Catenibacterium mitsuokai species to be significantly more prevalent in non-urbanized populations, compared urbanized ones. We isolated and characterized a strain of this from stool healthy adult volunteer. Strain CMD8551 T is strictly anaerobic, appears as long chains Gram-positive rods produces acetate presence glucose. The lipidomic profile showed higher proportion saturated lipid amongst detected...
Unhealthy dietary habits and highly caloric foods induce metabolic alterations promote the development of inflammatory consequences obesity, insulin resistance, diabetes cardiovascular diseases. Describing an effect diet is difficult to pursue, owing lacks standardized quali-quantitative assessments. The Dietary Inflammatory Index (DII) has been proposed as estimator pro- or anti-inflammatory nutrients higher DII values, which indicate increased intake with pro-inflammatory effects, relate...
A strain from a previously undescribed species belonging to the Catenibacterium genus was isolated stool of healthy volunteer. The is strictly anaerobic, and genome encodes CRISPR-Cas system genes related trimethylamine production.
Bacterial isolation is necessary for functional and mechanistic analyses, the increased human microbiome diversity revealed by metagenomic sequencing expanding relevant cultivation targets. Here, we report 46 draft genome sequences of bacterial isolates obtained from fecal samples healthy adults in Trento Milan (Italy), including strains seven taxonomically uncharacterized species.
Abstract Background and aim: Unhealthy dietary habits highly caloric foods induce metabolic alterations promote the development of inflammatory consequences obesity insulin resistance, which are epidemic conditions leading to diabetes cardiovascular diseases. Describing an effect diet is difficult pursue, owing lack quali-quantitative assessment standardization. The Dietary Inflammatory Index (DII) has been proposed as estimator pro- or anti-inflammatory nutritional components. Higher DII...
<h3>Background</h3> The advent of immune checkpoint inhibition (ICI) therapy markedly improved the outcome for melanoma. However, response remains heterogeneous, with about half patients being refractory or developing relapse. Although a causal link between gut microbiota and modulation antitumor has been established, current knowledge is limited to findings from cross-sectional analyses. Here, we follow melanoma over course anti-PD1 therapy, delineate changes related host identify factors...