A5075056333- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Nitric Oxide and Endothelin Effects
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Hormonal Regulation and Hypertension
- Cardiovascular Syncope and Autonomic Disorders
- Long-Term Effects of COVID-19
- Sodium Intake and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Advanced MRI Techniques and Applications
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Fatty Acid Research and Health
- Renin-Angiotensin System Studies
- Vitamin C and Antioxidants Research
King's College London
2015-2024
British Heart Foundation
2015-2024
St Thomas' Hospital
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2012-2024
St. Thomas Hospital
1993-2024
Royal Brompton Hospital
2024
Imperial College London
2012-2024
National Institute for Health Research
2011-2023
King's College School
2005-2023
King's College Hospital
2004-2023
Stiffness of elastic arteries like the aorta predicts cardiovascular risk. By directly reflecting arterial stiffness, having best predictive value for outcome and ease its measurement, carotid-femoral pulse wave velocity is now considered gold standard stiffness assessment in daily practice. Many different measurement procedures have been proposed. Therefore, standardization urgently needed, particularly regarding distance measurement. This consensus document advises on general provides...
The stiffness of the aorta can be determined by measuring carotid–femoral pulse wave velocity (PWVcf). PWV may also influence contour peripheral pulse, suggesting that analysis might used to assess large artery stiffness. An index (SIDVP) derived from digital volume (DVP) measured transmission IR light (photoplethysmography) was examined. SIDVP obtained subject height and time delay between direct reflected waves in DVP. timing these components DVP is arteries. was, therefore, expected...
Background— This study sought to evaluate whether risks of diabetes mellitus and cardiovascular disease are elevated across a range organ-specific multisystem chronic inflammatory disorders. Methods Results— A matched cohort was implemented in the UK Clinical Practice Research Datalink including participants with severe psoriasis (5648), mild (85 232), bullous skin diseases (4284), ulcerative colitis (12 203), Crohn’s (7628), arthritis (27 358), systemic autoimmune disorders (7472),...
The gut microbiome influences metabolic syndrome (MetS) and inflammation is therapeutically modifiable. Arterial stiffness poorly correlated with most traditional risk factors. Our aim was to examine whether microbial composition associated arterial stiffness. We assessed the correlation between carotid-femoral pulse wave velocity (PWV), a measure of stiffness, in 617 middle-aged women from TwinsUK cohort concurrent serum metabolomics data. Pulse negatively alpha diversity (Shannon index,...
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It widely measured by both consumer and clinical devices. However, the physical determinants PW are not yet fully understood, development analysis algorithms limited lack data sets containing reference CV measurements. Our aim was to create database PWs simulated computer span range conditions, representative sample healthy adults. typical properties 25–75 yr olds were identified through literature...
Acute Coronavirus Disease 2019 (COVID-19) has been associated with new-onset cardiovascular disease (CVD) and diabetes mellitus (DM), but it is not known whether COVID-19 long-term impacts on cardiometabolic outcomes. This study aimed to determine the incidence of new DM CVDs are increased over 12 months after compared matched controls. We conducted a cohort from 2020 2021 analysing electronic records for 1,356 United Kingdom family practices population 13.4 million. Participants were...
Smart wearables provide an opportunity to monitor health in daily life and are emerging as potential tools for detecting cardiovascular disease (CVD). Wearables such fitness bands smartwatches routinely the photoplethysmogram signal, optical measure of arterial pulse wave that is strongly influenced by heart blood vessels. In this survey, we summarize fundamentals wearable photoplethysmography its analysis, identify clinical applications, outline pressing directions future research order...
Aortic augmentation index, a measure of central systolic blood pressure arising mainly from pressure-wave reflection, increases with vascular aging. The index is influenced by aortic pulse-wave velocity (related to stiffness) and the site extent wave reflection. To clarify relative influence reflection on we studied association between velocity, age examined effects vasoactive drugs determine whether altering tone has differential index. We made simultaneous measurements carotid-to-femoral...
Nebivolol, a beta 1 selective adrenergic receptor antagonist with additional properties, is racemic mixture of (S,R,R,R)- and (R,S,S,S)-enantiomers. We investigated its effects on human forearm vasculature. Blood flow was measured using venous occlusion plethysmography during brachial artery infusion drugs. Interaction between nebivolol the L-arginine/nitric oxide pathway via comparison carbachol (an endothelium-dependent agonist) nitroprusside, by coinfusion competitive inhibitor nitric...
Previous studies suggest that vascular endothelial function may be impaired in essential hypertension. Although muscarinic agonists dilate blood vessels by releasing an endothelium-derived relaxing factor closely related to nitric oxide, nitroprusside dilates a mechanism is independent of the endothelium. The finding response but normal patients with hypertension has suggested abnormal
Abstract —The digital volume pulse can be recorded simply and noninvasively by photoplethysmography. The objective of the present study was to determine whether a generalized transfer function used relate peripheral pressure and, hence, both waveforms are influenced same mechanism. photoplethysmography in 60 subjects (10 women, aged 24 80 years), including 20 with previously diagnosed hypertension. Simultaneous recordings radial artery were obtained applanation tonometry servocontrolled cuff...
Carotid-femoral pulse wave velocity (PWV), a measure of arterial stiffness, is determined from the time taken for to propagate carotid femoral artery. Propagation measured variously foot waveform or point maximum upslope. We investigated whether these methods give comparable values PWV at rest, during β-adrenergic stimulation, and pacing-induced tachycardia. In subjects rest (n=43), obtained using foot-to-foot method (SphygmoCor system) were 1.7±0.75 m/s (mean±SD) greater than those slope...
Abstract —There is indirect evidence for a gender difference in nitric oxide (NO) synthesis from vascular endothelium. The aim of the present study was to determine NO production more directly healthy women and men by measurement 15 N nitrate excreted urine after intravenous administration l -[ N] 2 -guanidino arginine. Twenty-four volunteers (13 aged 22 40 years 11 23 42 years) participated this study. No subjects were receiving any medication. Women studied between 7th 14th days their...
We examined whether vasodilator responses to beta-agonists in human forearm vasculature are mediated part through the nitric oxide pathway.We measured blood flow brachial artery infusions of beta-adrenergic agonists healthy men. Salbutamol was more than 100 times as potent dobutamine. Cumulative doses salbutamol (0.3 3.5 nmol.min-1) did not cause tachyphylaxis an identical repeated infusion after a 24-minute recovery period. Vasodilators were infused with this sequence during coinfusion...