A5057093962- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Hemodynamic Monitoring and Therapy
- Cardiovascular Disease and Adiposity
- Galaxies: Formation, Evolution, Phenomena
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Adaptive optics and wavefront sensing
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Astronomy and Astrophysical Research
- Pancreatic function and diabetes
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- Neuroscience and Neuropharmacology Research
- Cardiovascular Effects of Exercise
- Metabolism, Diabetes, and Cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Diet, Metabolism, and Disease
- Menopause: Health Impacts and Treatments
Brigham Young University
2024
South Infirmary Victoria University Hospital
2018
Stony Brook University Hospital
2018
Stony Brook University
2018
National University of Singapore
2015
Eli Lilly (Singapore)
2013
King's College London
2001-2002
Max Planck Institute of Molecular Physiology
2002
St Thomas' Hospital
2000-2002
St Vincent's Hospital Sydney
1985-2000
Arterial pressure waves were recorded noninvasively from the carotid, radial, femoral, or all three of these arteries 1,005 normal subjects, aged 2-91 years, using a new transcutaneous tonometer containing high fidelity Millar micromanometer. Waves ensemble-averaged into age-decade groups. Characteristic changes noted with increasing age. In sites, pulse amplitude increased advancing age (carotid, 91.3%; radial 67.5%; 50.1% first to eighth decade), diastolic decay steepened, and became less...
BACKGROUND This study tested whether the simple ratio of ventricular end-systolic pressure to stroke volume, known as effective arterial elastance (Ea), provides a valid measure load in humans with normal and aged hypertensive vasculatures. METHODS AND RESULTS Ventricular pressure-volume invasive aortic flow were simultaneously determined 10 subjects (four young normotensive six older hypertensive). Measurements obtained at rest, during mechanically reduced preload, after pharmacological...
The stiffness of the aorta can be determined by measuring carotid–femoral pulse wave velocity (PWVcf). PWV may also influence contour peripheral pulse, suggesting that analysis might used to assess large artery stiffness. An index (SIDVP) derived from digital volume (DVP) measured transmission IR light (photoplethysmography) was examined. SIDVP obtained subject height and time delay between direct reflected waves in DVP. timing these components DVP is arteries. was, therefore, expected...
Aortic augmentation index, a measure of central systolic blood pressure arising mainly from pressure-wave reflection, increases with vascular aging. The index is influenced by aortic pulse-wave velocity (related to stiffness) and the site extent wave reflection. To clarify relative influence reflection on we studied association between velocity, age examined effects vasoactive drugs determine whether altering tone has differential index. We made simultaneous measurements carotid-to-femoral...
This study tests the hypothesis that arterial vascular stiffening adversely influences in situ left ventricular contractile function and energetic efficiency. Ten reflex-blocked anesthetized dogs underwent a bypass operation which Dacron graft was sewn to ascending aorta connected infrarenal abdominal via plastic conduit. Flow directed through either native or conduit by placement of clamps. Arterial properties were measured from aortic pressure-flow data, assessed pressure-volume (PV)...
Nitroglycerin (0-3 mg) was administeredsublingually to 14patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta brachial artery. After nitroglycerin, aortic systolic fell all cases (by 6–44, average 22 mmHg) whereas remained unchanged (in three) or a lesser degree (4–33, average12 mmHg). Diastolic did not change significantly. Alterations wave contour were explained on basis of arterial dilation, with reduction reflection. reduces left ventricular...
In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with first evolving myocardial infarction onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion 100 mg recombinant tissue-type plasminogen activator (rt-PA) or placebo over 3 hr. The groups at entry similar. At assessment 21 days later, left ventricular ejection fraction measured both by contrast radionuclide...
We compared dilevalol (an isomer of labetalol), 200-400 mg daily, against atenolol, 50-100 in a double-blind, crossover, placebo-controlled trial with respect to effects on arterial distensibility (measured as pulse wave velocity [PWV]) and reflection (assessed from carotid pressure contour). Twelve patients mean age 58 years (range 44-73 years) essential hypertension (supine diastolic blood 95-114 mm Hg) took active therapy for 12 weeks, separated by 2-4 week placebo period. Carotid...
Aim To describe the clinical effects of single and multiple doses a potent, selective, orally administered, small‐molecule antagonist human glucagon receptor, LY2409021 , in healthy subjects patients with type 2 diabetes. Methods was administered dose‐escalation studies to (n = 23) diabetes 9) as ( S tudy 1) daily 47) for 28 days 2). Safety, tolerability, pharmacokinetic PK ) pharmacodynamic PD assessments were made after receiving once‐daily (5, 30, 60 or 90 mg) days. Results well tolerated...
Assembly of muscle sarcomeres is a complex dynamic process and involves large number proteins. A growing these have regulatory functions are transiently present in the myofibril. We show here that novel tubulin-associated RING/B-box protein MURF2 associates with microtubules, myosin titin during sarcomere assembly. During assembly, first microtubules at exclusion tyrosinated tubulin. Then, MURF2-labelled associate sarcomeric later A-band when non-striated myofibrils differentiate into mature...
Galaxy sizes correlate with many other important properties of galaxies, and the cosmic evolution galaxy is an observational diagnostic for constraining models. The effective radius probably most widely used indicator size. We TNG50-SKIRT Atlas to investigate wavelength dependence galaxies at optical near-infrared (NIR) wavelengths. find that, on average, in every band exceeds stellar mass radius, that this excess systematically decreases increasing wavelength. g -band (NIR K s -band)...
Abstract —Less than 50% of the variance in left ventricular mass is explained by conventional factors such as age, blood pressure, and body size. Genetic influences may account for part unexplained variance. The central (aortic) pressure augmentation index has been suggested a noninvasive measure pulsatile load, which likely determinant mass. We quantified genetic influence on determined extent to this dependent effects height, heart rate, pressure. performed classical twin study composed...
Galaxy morphology is a powerful diagnostic to assess the realism of cosmological hydrodynamical simulations. Determining simulated galaxies requires generation synthetic images through 3D radiative transfer post-processing that properly accounts for different stellar populations and interstellar dust attenuation. We use SKIRT code generate TNG50-SKIRT Atlas, UV near-infrared broadband image atlas complete stellar-mass selected sample 1154 extracted from TNG50 simulation at z = 0. The have...
To determine the detailed effects of hormone replacement therapy (HRT) on non-invasive haemodynamics, including an assessment effect pulsatile afterload assessed in terms augmentation index and pulse-wave velocity.A cross-sectional study healthy postmenopausal women using carotid radial tonometry velocity measurements.Community-based ambulatory attending menopause centre at a tertiary hospital.Seventy divided into those not currently being administered HRT (n = 38, aged 46-72 years) who were...
1. The whole‐cell configuration of the patch clamp technique was used to study inward and delayed outward currents in beta‐cells isolated from human pancreatic islets. 2. current activated at about ‐20 mV increased linearly with further depolarization. instantaneous current‐voltage (I‐V) relation, measured by tail analysis, reversed ‐70 mV. This is close K+ equilibrium potential suggests carried primarily potassium ions. In support this idea, were abolished when internal replaced impermeant...