A5021529820- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Pharmaceutical studies and practices
- Heart Rate Variability and Autonomic Control
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Hormonal and reproductive studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacogenetics and Drug Metabolism
- Renin-Angiotensin System Studies
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and exercise physiology
- Antioxidant Activity and Oxidative Stress
- Pharmacology and Obesity Treatment
- Receptor Mechanisms and Signaling
- Clinical practice guidelines implementation
- Pharmaceutical Practices and Patient Outcomes
- Cardiovascular Function and Risk Factors
- Statistical Methods in Clinical Trials
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical Economics and Policy
- Cardiac Arrhythmias and Treatments
- Pharmaceutical industry and healthcare
Charité - Universitätsmedizin Berlin
2024
German Rheumatism Research Centre
2024
St Thomas' Hospital
2005-2023
GlaxoSmithKline (United Kingdom)
2019
Guy's Hospital
1990-2018
IQVIA (United Kingdom)
2012-2018
King's College London
2006-2015
Faculty (United Kingdom)
2015
University College London
1995-2015
King's College Hospital
1999-2010
The amyloid fibril deposits that cause systemic amyloidosis always contain the nonfibrillar normal plasma protein, serum P component (SAP). drug (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC) efficiently depletes SAP from but leaves some in can be specifically targeted by therapeutic IgG anti-SAP antibodies. In murine A type amyloidosis, binding of these antibodies to residual activates complement and triggers rapid clearance macrophage-derived...
Aortic augmentation index, a measure of central systolic blood pressure arising mainly from pressure-wave reflection, increases with vascular aging. The index is influenced by aortic pulse-wave velocity (related to stiffness) and the site extent wave reflection. To clarify relative influence reflection on we studied association between velocity, age examined effects vasoactive drugs determine whether altering tone has differential index. We made simultaneous measurements carotid-to-femoral...
Previous studies suggest that vascular endothelial function may be impaired in essential hypertension. Although muscarinic agonists dilate blood vessels by releasing an endothelium-derived relaxing factor closely related to nitric oxide, nitroprusside dilates a mechanism is independent of the endothelium. The finding response but normal patients with hypertension has suggested abnormal
Abstract —The digital volume pulse can be recorded simply and noninvasively by photoplethysmography. The objective of the present study was to determine whether a generalized transfer function used relate peripheral pressure and, hence, both waveforms are influenced same mechanism. photoplethysmography in 60 subjects (10 women, aged 24 80 years), including 20 with previously diagnosed hypertension. Simultaneous recordings radial artery were obtained applanation tonometry servocontrolled cuff...
Abstract —There is indirect evidence for a gender difference in nitric oxide (NO) synthesis from vascular endothelium. The aim of the present study was to determine NO production more directly healthy women and men by measurement 15 N nitrate excreted urine after intravenous administration l -[ N] 2 -guanidino arginine. Twenty-four volunteers (13 aged 22 40 years 11 23 42 years) participated this study. No subjects were receiving any medication. Women studied between 7th 14th days their...
We examined whether vasodilator responses to beta-agonists in human forearm vasculature are mediated part through the nitric oxide pathway.We measured blood flow brachial artery infusions of beta-adrenergic agonists healthy men. Salbutamol was more than 100 times as potent dobutamine. Cumulative doses salbutamol (0.3 3.5 nmol.min-1) did not cause tachyphylaxis an identical repeated infusion after a 24-minute recovery period. Vasodilators were infused with this sequence during coinfusion...
Synthesis of the aortic pressure waveform by application a transfer function to radial pulse allows estimation systolic blood and augmentation index, an index wave reflection derived from early component waveform. The accuracy this approach for determining has been questioned, however, it may be possible derive similar information without using function. We compared obtained carotid arteries with use functions. examined correlation between Arterial tonometry (Sphygmocor) was performed in 84...
Endothelial damage is believed to play a key role in the development of both micro- and macrovascular disease diabetes, advanced glycation end products (AGEs) may contribute importantly this. To determine whether glucose-derived AGEs can cause endothelial dysfunction, we examined effects albumin AGE-modified by glucose (AGE-Glu) vivo, after injection into rabbit femoral artery, vitro on aortic rings cultured human umbilical vein cells (HUVEC). Exposure blood vessels AGE-Glu, vivo vitro,...
Background —Genistein, a phytoestrogen, may have estrogenic cardioprotective actions. We investigated whether genistein influences endothelium-dependent vasodilation in forearm vasculature of healthy human subjects and compared the effects with those 17β-estradiol. Methods Results —The brachial arterial was cannulated 27-gauge needle for drug infusion. Forearm blood flow responses were measured strain-gauge plethysmography. Genistein (10 to 300 nmol/min, each dose 6 minutes) produced...
Repeat cycles of miridesap, to deplete circulating serum amyloid P component (SAP), followed by the anti-SAP antibody, dezamizumab, cleared visceral deposits in patients with systemic amyloidosis.
Some animal studies suggest that β‐adrenoceptor‐mediated vasorelaxation is in part mediated through nitric oxide (NO) release. Furthermore, humans, we have recently shown forearm blood flow increased by infusion of β 2 ‐adrenergic agonists into the brachial artery, and synthase (NOS) inhibitor N G ‐monomethyl‐ L ‐arginine ( ‐NMMA) inhibits this response. The purpose present study was to determine whether stimulation human umbilical vein endothelial β‐adrenoceptors causes generation, might be...
Aortic stiffness, as measured by carotid-femoral pulse wave velocity (PWV), is a powerful, independent predictor of vascular risk. PWV in muscular arteries influenced basal nitric oxide (NO) release. It not known whether NO also influences PWV. We examined the effects an synthase inhibitor, NG-monomethyl-l-arginine (L-NMMA), on and aortic augmentation index (AIx, indirect measure arterial stiffness). To control for L-NMMA distending pressure, we used doses norepinephrine dobutamine that...
Type II diabetes is characterized by increased oxidative stress, endothelial dysfunction and hypertension. We investigated whether short-term treatment with oral vitamin C reduces stress improves function blood pressure in subjects diabetes. Subjects ( n =35) received (1.5 g daily three doses) or matching placebo for 3 weeks a randomized, double-blind, parallel-group design. Plasma concentrations of 8-epi-prostaglandin F(2alpha) (8-epi-PGF(2alpha)), non-enzymically derived oxidation product...
Metabolic factors, including plasma concentrations of cholesterol and insulin resistance, may influence blood pressure through effects on vascular reactivity. Such might during exercise more strongly than at rest.We examined whether there is an association between serum or resistance change in mild exercise. Blood was measured rest fixed low-workload bicycle ergometry (50, 75, 100 W, each for 3 minutes) 75 healthy active men (age, 18 to 66 years). not significantly correlated with (estimated...
Immunization against components of the renin–angiotensin system offers a potential alternative to daily medication in some patients with hypertension or heart failure. Our primary objective was determine whether sustained antibody titre Ang I (angiotensin I) can be achieved hypertensive patients. The secondary antibodies block renin system. Patients (n=27) essential responsive an ACEi (angiotensin-converting enzyme inhibitor) ARB blocker) were randomly assigned receive three four injections...
Hypertension and type 2 diabetes are associated with increased aortic pulse wave velocity (PWV), a measure of stiffness powerful risk factor for cardiovascular events. The association hypertension may obscure the degree to which rather than contributes an elevated PWV. objective this study was determine whether presence is PWV compared nondiabetic subjects matched mean arterial blood pressure. determined by measuring carotid femoral transit time using applanation tonometry in 186 (104 women)...