A5100339274- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Neutrino Physics Research
- Blood Pressure and Hypertension Studies
- Non-Invasive Vital Sign Monitoring
- Particle physics theoretical and experimental studies
- Dark Matter and Cosmic Phenomena
- Astrophysics and Cosmic Phenomena
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Particle Detector Development and Performance
- Heart Rate Variability and Autonomic Control
- Radiation Detection and Scintillator Technologies
- Cerebrovascular and Carotid Artery Diseases
- Hemodynamic Monitoring and Therapy
- Cardiovascular Disease and Adiposity
- Advanced X-ray and CT Imaging
- Elasticity and Material Modeling
- Connective tissue disorders research
- Radiomics and Machine Learning in Medical Imaging
- Cardiac pacing and defibrillation studies
- MRI in cancer diagnosis
- Cardiac Arrhythmias and Treatments
- Cardiovascular and exercise physiology
- Advanced Fluorescence Microscopy Techniques
Hebei Medical University
2011-2025
Dalian Medical University
2022-2024
First Affiliated Hospital of Dalian Medical University
2022-2024
Brookhaven National Laboratory
2015-2024
Capital Medical University
2016-2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Guangdong Provincial People's Hospital
2024
British Heart Foundation
2014-2023
King's College London
2014-2023
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It widely measured by both consumer and clinical devices. However, the physical determinants PW are not yet fully understood, development analysis algorithms limited lack data sets containing reference CV measurements. Our aim was to create database PWs simulated computer span range conditions, representative sample healthy adults. typical properties 25–75 yr olds were identified through literature...
The development and operation of liquid-argon time-projection chambers for neutrino physics has created a need new approaches to pattern recognition in order fully exploit the imaging capabilities offered by this technology. Whereas human brain can excel at identifying features recorded events, it is significant challenge develop an automated, algorithmic solution. Pandora Software Development Kit provides functionality aid design implementation pattern-recognition algorithms. It promotes...
We describe the concept and procedure of drifted-charge extraction developed in MicroBooNE experiment, a single-phase liquid argon time projection chamber (LArTPC). This technique converts raw digitized TPC waveform to number ionization electrons passing through wire plane at given time. A robust recovery from both induction collection anode planes will augment 3D reconstruction, is particularly important for tomographic reconstruction algorithms. building blocks overall are described. The...
We present several studies of convolutional neural networks applied to data coming from the MicroBooNE detector, a liquid argon time projection chamber (LArTPC). The algorithms studied include classification single particle images, localization and neutrino interactions in an image, detection simulated event overlaid with cosmic ray backgrounds taken real detector data. These demonstrate potential for identification or on interactions. also address technical issues that arise when applying...
The single-phase liquid argon time projection chamber (LArTPC) provides a large amount of detailed information in the form fine-grained drifted ionization charge from particle traces. To fully utilize this information, deposited must be accurately extracted raw digitized waveforms via robust signal processing chain. Enabled by ultra-low noise levels associated with cryogenic electronics MicroBooNE detector, precise extraction induction wire planes LArTPC is qualitatively demonstrated on data...
The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution ionization charge deposited on wire planes TPC, especially for induction planes. This paper describes characteristics and mitigation observed noise MicroBooNE detector. MicroBooNE's single-phase LArTPC comprises two one collection sense plane with total 8256 wires. Current induced each TPC amplified shaped by custom low-power, ASICs immersed...
Augmentation pressure (AP), the increment in aortic above its first systolic shoulder, is thought to be determined mainly by wave reflection but could influenced ventricular ejection characteristics. We sought determine mechanism which AP selectively reduced nitroglycerin (NTG). Simultaneous measurements of and flow were made at time cardiac catheterization 30 subjects (11 women; age, 61±13 years [mean±SD]) perform intensity analysis calculate forward backward components generated ventricle...
Large liquid argon time projection chambers (LArTPCs), especially those operating near the surface, are susceptible to space charge effects. In context of LArTPCs, effect is build-up slow-moving positive ions in detector primarily due ionization from cosmic rays, leading a distortion electric field within detector. This leads displacement reconstructed position signal electrons LArTPC detectors ("spatial distortions"), as well variations amount electron-ion recombination experienced by...
We describe a method used to calibrate the position- and time-dependent response of MicroBooNE liquid argon time projection chamber anode wires ionization particle energy loss. The makes use crossing cosmic-ray muons partially correct wire signals for multiple effects as function position, including cross-connected TPC wires, space charge effects, electron attachment impurities, diffusion, recombination. overall scale is then determined using fully-contained beam-induced originating stopping...
Liquid argon time projection chambers (LArTPCs) are now a standard detector technology for making accelerator neutrino measurements, due to their high material density, precise tracking, and calorimetric capabilities. An electric field (E-field) is required in such detectors drift ionization electrons the anode where they collected. The E-field of TPC often approximated be uniform between cathode planes. However, significant distortions can appear from effects as mechanical deformations,...
Abstract Primary challenges for current and future precision neutrino experiments using liquid argon time projection chambers (LArTPCs) include understanding detector effects quantifying the associated systematic uncertainties. This paper presents a novel technique assessing propagating LArTPC detector-related The makes modifications to simulation waveforms based on parameterization of observed differences in ionization signals from TPC between data simulation, while remaining insensitive...
Hyperglycemia induces chronic inflammation and oxidative stress in cardiomyocyte, which are the main pathological changes of diabetic cardiomyopathy (DCM). Treatment aimed at these processes may be beneficial DCM. Phloretin (PHL), a promising natural product, has many pharmacological activities, such as anti-inflammatory, anticancer, anti-oxidative function. The aim this study was to investigate whether PHL could ameliorate high glucose-mediated oxidation, hypertrophy, fibrosis H9c2 cells...
Impaired shortening deactivation of cardiac myocytes could sustain myocardial contraction, preserving ejection fraction at the expense diastolic dysfunction. We examined relationship between first-phase (EF1), left ventricular volume ejected from start systole to time first peak in pressure (corresponding maximal shortening) duration contraction and function patients with hypertension (n=163), varying degrees Left systolic was estimated by carotid tonometry; time-resolved cavity wall were...
We tested the hypothesis that increased pulse wave reflection and altered backward waveform morphology contribute to pressure in subjects with higher compared lower actions of vasoactive drugs increase pressure. examined relationship forward 158 who were evaluated for hypertension (including some normotensive subjects) divided into 3 groups by central pressure: group 1, 33±6.5 mm Hg; 2, 45±4.1 3, 64±12.9 Hg (means±SD) healthy during administration inotropic vasomotor drugs. Aortic flow...
The MicroBooNE liquid argon time projection chamber (LArTPC) has been taking data at Fermilab since 2015 collecting, in addition to neutrino beam, cosmic-ray muons. Results are presented on the reconstruction of Michel electrons produced by decay rest abundantly TPC, and given their well known energy spectrum can be used study MicroBooNE's detector response low-energy (electrons with energies up ~ 50 MeV). We describe fully-automated algorithm developed reconstruct electrons, which a sample...
Sarcopenia is a common complication in elderly patients with coronary heart disease (CHD). This study aims to analyse and explore the occurrence of sarcopenia CHD its associations short-term prognosis. A total 318 were enrolled between March 2020 2022. was assessed at admission using grip strength gait speed; subsequently, clinical data, cardiac function indicators, adverse events mortality compared two groups prognosis CHD. Among included this study, 69 developed sarcopenia, an incidence...
Recently, the necessity of term "small for gestational age" (SGA) has been questioned in fetal growth studies.1 Researchers have argued that, while this describes fetuses small size, it does not necessarily indicate restriction (FGR), which can both short- and long-term consequences. Consequently, its use studies may introduce bias. Although is acknowledged that all a pathological condition any size potentially be pathological,2 we believe SGA remains irreplaceable clinical practice. To...
We report results from an updated search for neutral current (NC) resonant $\Delta$(1232) baryon production and subsequent $\Delta$ radiative decay (NC $\Delta\rightarrow N \gamma$). consider events with without final state protons; a proton can be compared the kinematics of $\Delta(1232)$ decay, while visible represent more generic phase space. In order to maximize sensitivity each topology, we simultaneously make use two different reconstruction paradigms, Pandora Wire-Cell, which have...
We present an inclusive search for anomalous production of single-photon events from neutrino interactions in the MicroBooNE experiment. The and its signal definition are motivated by previous observation a low-energy excess electromagnetic shower MiniBooNE use Wire-Cell reconstruction framework to select sample final-state with final efficiency purity 7.0% 40.2%, respectively. leverage simultaneous measurements sidebands charged current $\nu_{\mu}$ neutral producing $\pi^{0}$ mesons...
This article presents the first search for neutrino-induced neutral current coherent single-photon production (NC 1$\gamma$). The makes use of data from MicroBooNE 85-tonne active volume liquid argon time projection chamber detector, situated in Fermilab Booster Neutrino Beam (BNB), with an average neutrino energy $\langle E_{\nu}\rangle \sim 0.8$ GeV. A targeted selection candidate interactions a single photon-like electromagnetic shower final state and no visible vertex activity was...
We examined the ability of a simple reduced model comprising proximal characteristic impedance linked to Windkessel element accurately predict central pulse pressure (PP) from aortic blood flow, verified that parameters corresponded physical properties, and applied examine PP dependence on cardiac vascular properties. obtained was compared with theoretical values in silico measured vivo. Theoretical were using distributed multisegment population virtual (computed) subjects which...
Abstract Stiffening of the aorta is an important independent risk factor for myocardial infarction and stroke. Yet its genetics complex little known about molecular drivers. We have identified first time, tagSNPs in genes extracellular matrix proteins, aggrecan fibulin-1, that modulate stiffness young healthy adults. confirmed SNP associations with ex vivo measurements expression studies human donor aortic tissues. Both fibulin-1 were found wall, but marked differences distribution...
Abstract Aims Haemodynamic determinants of blood pressure (BP) include cardiac output (CO), systemic vascular resistance (SVR), and arterial stiffness. We investigated the heritability these phenotypes, their association with BP-related single-nucleotide polymorphisms (SNPs), causal between BP Methods results assessed BP, central components, haemodynamic properties (during a single visit) including CO, SVR, pulse wave velocity (PWV, measure stiffness) in 3531 (1934 monozygotic, 1586...
Pulsatile components of blood pressure may arise from forward (ventricular generated) or backward wave travel in the arterial tree. The objective this study was to determine relative contributions and waves pulsatility. We used intensity separation analysis pulsatile during inotropic vasopressor stimulation by dobutamine norepinephrine normotensive subjects compared pulse hypertensive (mean±SD, 48.8±11.3 years; 165±26.6/99±14.2 mm Hg) (52.2±12.6 120±14.2/71±8.2 Hg). Dobutamine (7.5 μg/kg per...