A5103060733- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Domain Adaptation and Few-Shot Learning
- Transplantation: Methods and Outcomes
- Cardiovascular and exercise physiology
- Energy Load and Power Forecasting
- Nitric Oxide and Endothelin Effects
- Fuel Cells and Related Materials
- Congenital Heart Disease Studies
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Aerospace and Aviation Technology
- Advanced MRI Techniques and Applications
- Long-Term Effects of COVID-19
- Machine Learning and ELM
British Heart Foundation
2015-2023
King's College London
2014-2023
Stevens Institute of Technology
2023
China University of Mining and Technology
2022
NARI Group (China)
2022
King & Spalding
2021
Pulmonary Vascular Research Institute
2021
St. Thomas Hospital
2020
Geomechanica (Canada)
2020
Institute of Seismology
2020
Impaired shortening deactivation of cardiac myocytes could sustain myocardial contraction, preserving ejection fraction at the expense diastolic dysfunction. We examined relationship between first-phase (EF1), left ventricular volume ejected from start systole to time first peak in pressure (corresponding maximal shortening) duration contraction and function patients with hypertension (n=163), varying degrees Left systolic was estimated by carotid tonometry; time-resolved cavity wall were...
We tested the hypothesis that increased pulse wave reflection and altered backward waveform morphology contribute to pressure in subjects with higher compared lower actions of vasoactive drugs increase pressure. examined relationship forward 158 who were evaluated for hypertension (including some normotensive subjects) divided into 3 groups by central pressure: group 1, 33±6.5 mm Hg; 2, 45±4.1 3, 64±12.9 Hg (means±SD) healthy during administration inotropic vasomotor drugs. Aortic flow...
We examined the ability of a simple reduced model comprising proximal characteristic impedance linked to Windkessel element accurately predict central pulse pressure (PP) from aortic blood flow, verified that parameters corresponded physical properties, and applied examine PP dependence on cardiac vascular properties. obtained was compared with theoretical values in silico measured vivo. Theoretical were using distributed multisegment population virtual (computed) subjects which...
Systemic arterial hypertension predisposes children to cardiovascular risk in childhood and adult life. Despite extensive study of left ventricular (LV) hypertrophy, detailed 3-dimensional strain analysis cardiac function hypertensive has not been reported. The aim this was evaluate LV mechanics (strain, twist, torsion) young patients with compared a healthy control group assess factors associated functional measurements. Sixty-three (26 37 normotensive) were enrolled (mean age, 14.3 11.4...
Chronic low-dose cabergoline treatment for microprolactinoma may cause cardiac valve pathology, but the evidence is contradictory. We investigated whether expectation of echocardiographer could influence report.Transthoracic echocardiograms from 40 patients aged 49·3 ± 9·6 (mean SD) years (Men:Women 7:33) on long-term and bromocriptine therapy (duration 9·94 4·5 years) were randomly assigned to two groups echocardiographers so that each echocardiogram was reported twice. One group told 'the...
Aims The aims of the present study were to explore whether a long‐term intervention with dietary nitrate [(NO 3 − ), potential tolerance‐free source beneficial vasoactive nitric oxide] and spironolactone (to oppose aldosterone's deleterious cardiovascular effects) improve cardiac structure/function, independently blood pressure (BP), in patients with/at risk type 2 diabetes (a population at heart failure). Methods A subsample participants our double‐blind, randomized, factorial‐design...
Objective First-phase ejection fraction (EF1) is a novel measure of early left ventricular systolic dysfunction. We investigated determinants EF1 and its prognostic value in aortic stenosis. Methods was measured retrospectively participants an echocardiography/cardiovascular magnetic resonance cohort study which recruited patients with stenosis (peak velocity ≥2 m/s) between 2012 2014. Linear regression models were constructed to examine variables associated EF1. Cox proportional hazards...
Background Primary hypertension in children is often characterized by high pulse pressure that could be attributable to increased ventricular ejection velocities and volumes and/or arterial stiffness. The objective of this study was examine the contributions cardiac (ventricular ejection) vascular (systemic resistance, stiffness, wave reflection) properties primary adolescents. Methods Results Children aged 8 18 years referred a tertiary center for evaluation found have (n=31) were compared...
Objectives: To evaluate the effect of in-hospital pulmonary rehabilitation (PR) on short-term functional recovery in patients with COVID-19. Methods: Patients COVID-19 ( n = 123) were divided into two groups (PR group or Control group) according to recipient rehabilitation. Six-min walk distance (6MW), heart rate (HR), forced vital capacity (FVC), expiratory volume 1 s (FEV ), diffusing lung for carbon monoxide (DL CO and CT scanning measured at time discharge, 1, 4, 12, 24 weeks. Results:...
Presence of heart failure is associated with a poor prognosis in patients coronavirus disease 2019 (COVID-19). The aim the present study was to examine whether first-phase ejection fraction (EF1), measured early systole up time peak aortic velocity, sensitive measure preclinical failure, survival hospitalized COVID-19. A retrospective outcome performed COVID-19 who underwent echocardiography (n=380) at West Branch Union Hospital, Wuhan, China and admitted King's Health Partners South London,...
We examined the influence of arterial stiffening and ventricular ejection dynamics on age-related increase in central pulse pressure. A total 2033 women aged 18 to 91 years from Twins UK cohort were studied. Aortic flow blood pressure measured by Doppler sonography carotid tonometry, respectively. Measured values compared with predicted aortic wave velocity characteristics. Central at first shoulder ( P1) increased age 29.2±8.0 those <40 44.2±13.8 mm Hg >70 (means±SD; P<0.001), an explained...
Background: Lung injury is a common condition among hospitalized patients with coronavirus disease 2019 (COVID-19). However, whether lung ultrasound (LUS) score predicts all-cause mortality in COVID-19 unknown. The aim of the present study was to explore predictive value for COVID-19. Methods: Patients who underwent were prospectively enrolled from three hospitals Wuhan, China between February 2020 and March 2020. Demographic, clinical, laboratory data collected digital patient records....
First-phase ejection fraction (EF1), the EF at time to peak aortic jet velocity, has been proposed as a novel marker of systolic function in stenosis (AS). This study aimed explore association myocardial contractility and arterial load with EF1 AS patients.Data from prospective, cross-sectional 114 patients mild, moderate, severe preserved left ventricular (>50%) were analysed. was measured volume change end-diastole that corresponded velocity. Myocardial assessed by strain rate speckle...
There is growing recognition of hypertension in a significant proportion children with ADPKD. In this study, we assessed blood pressure and cardiovascular status A prospective two-centre observational study (< 18 years) ADPKD was compared against age- BMI-matched healthy controls. Children underwent peripheral BP (pBP) measured using an aneroid sphygmomanometer auscultation, 24-h ambulatory monitoring (ABPM), non-invasive central (cBP) measurement, carotid-femoral pulse wave velocity (PWVcf)...
Myocardial wall stress (MWS) is thought to be the mechanical stimulus ventricular hypertrophy. The objective of this study was examine whether MWS elevated in children with chronic kidney disease (CKD) who are at high risk developing adverse cardiovascular events related left (LV) MWS, a function pressure, myocardial volume, and cavity obtained using carotid tonometry estimate pressure 2-dimensional transthoracic echocardiographic wall-tracking obtain LV volumes. Ninety-two (50 boys) aged...
Abstract Background/Objectives Obesity in pregnancy has been associated with increased childhood cardiometabolic risk and reduced life expectancy. The UK UPBEAT multicentre randomised control trial was a lifestyle intervention of diet physical activity pregnant women obesity. We hypothesised that the 3-year-old children obesity would have heightened cardiovascular compared to normal BMI women, mitigate this risk. Subjects/Methods Children were recruited from one centre. Cardiovascular...
Aims: In hypertensive adults, first-phase ejection fraction (EF1), a measure of early ventricular contraction is reduced and associated with prolonged systolic diastolic dysfunction. Whether this true in children primary hypertension unknown. Methods: Echocardiography was performed 47 normotensive 81 children. Hypertensive were stratified according to tertiles LVMi (g/m 2.7 ). EF1 calculated from the LV volume ejected up time peak aortic flow. E / e’ used as function. Myocardial wall stress...
A novel method was presented to separate the central blood pressure wave (CBPW) into five components with different biophysical and temporal origins. It includes a time-varying emission coefficient ( γ) that quantifies pulse generation reflection at aortic root.The applied normotensive subjects modulated physiology by inotropic/vasoactive drugs (n = 13), hypertensive 158), virtual 4,374).γ is directly proportional flow throughout cardiac cycle. Mean peak γ increased increasing (from <30 >70...
Transfer learning is a popular paradigm for utilizing existing knowledge from previous tasks to improve the performance of new ones. It has enjoyed numerous empirical successes and inspired growing number theoretical studies. This paper addresses feasibility issue transfer learning. begins by establishing necessary mathematical concepts constructing framework then identifies formulates three-step procedure as an optimization problem, allowing resolution issue. Importantly, it demonstrates...
Adults with childhood-onset chronic kidney disease (CKD) have an increased risk of cardiovascular disease. First-phase ejection fraction (EF1), a novel measure early systolic function, may be more sensitive marker left ventricular dysfunction than other markers in children CKD.