A5012386391- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Sodium Intake and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Coffee research and impacts
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Function and Risk Factors
- Meat and Animal Product Quality
- Diet, Metabolism, and Disease
- Food Security and Health in Diverse Populations
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Obesity, Physical Activity, Diet
- Lipid metabolism and disorders
- Heart Rate Variability and Autonomic Control
University of North Carolina at Greensboro
2025
University of Reading
2013-2024
King's College London
2015-2023
King's College Hospital NHS Foundation Trust
2022
St Thomas' Hospital
2015-2021
Guy's and St Thomas' NHS Foundation Trust
2015-2021
Food & Nutrition
2020
Ghent University
2020
European Society of Cardiology
2020
Kings Health Partners
2016-2017
Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic (DBP) at least 90 (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. is associated with increased risk cardiovascular disease (CVD) events (e.g. coronary heart disease, failure and stroke) death. An international panel experts convened by the International College Experts compiled lifestyle management recommendations first-line strategy to...
Coffee is a relatively rich source of chlorogenic acids (CGA), which, as other polyphenols, have been postulated to exert preventive effects against CVD and type 2 diabetes. As considerable proportion ingested CGA reaches the large intestine, may be capable exerting beneficial in gut. Here, we utilise stirred, anaerobic, pH-controlled, batch culture fermentation model distal region colon order investigate impact coffee on growth human faecal microbiota. Incubation samples with microbiota led...
The beneficial health effects of cranberries have been attributed to their (poly)phenol content. Recent studies investigated the absorption, metabolism and excretion cranberry (poly)phenols; however, little is known about whether they follow a dose response in vivo at different levels intake. An acute double-blind randomized controlled trial 10 healthy men with juices containing 409, 787, 1238, 1534 1910 mg total (poly)phenols was performed. Blood urine were analyzed by UPLC-Q-TOF-MS. Sixty...
Background & aimsPolyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet studied. We aimed investigate the impact of coffee rich function and whether CGAs are involved potential effects.MethodsTwo acute randomized, controlled, cross-over intervention trials were conducted. The intake, matched for caffeine but differing CGA content (89, 310 mg) flow-mediated dilatation (FMD) was assessed 15...
Dietary nitrate (found in green leafy vegetables such as rocket and beetroot) is now recognized to be an important source of nitric oxide, via the nitrate-nitrite-NO pathway. confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency exercise. Having described key twists turns elucidation pathway underlying mechanisms Part I, we explore more recent developments which have served confirm mechanisms, extend our understanding,...
Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with failure diabetes and eNAMPT immuno-neutralisation improves glucose tolerance mouse models Despite this, effects on poorly elucidated, some studies having separately reported cell-protective eNAMPT. exists structurally functionally distinct monomeric dimeric forms. Dimerisation essential for...
This study aims to foster apparel students' knowledge of denim sustainability. The two research objectives were (1) increase about sustainability innovations and (2) enhance competency in applying this promote among brands. To address the objectives, we employed problem-oriented project-based learning (POPBL) as a pedagogical approach develop an experiential module.
Abstract Interesterified ( IE ) fats are used in a wide range of food products and were introduced as replacement for trans fats, which known to be detrimental cardiovascular health. However, the effects interesterification on metabolism subsequent health not understood previous studies have seldom investigated industrially‐relevant fats. No legislation currently exists regarding labelling therefore estimates average consumption rates UK population unavailable. In order meet urgent need...
To test if spironolactone or dietary nitrate from beetroot juice could reduce arterial stiffness as aortic pulse wave velocity (PWVart), a potential treatment target, independently of blood pressure.
Aims The aims of the present study were to explore whether a long‐term intervention with dietary nitrate [(NO 3 − ), potential tolerance‐free source beneficial vasoactive nitric oxide] and spironolactone (to oppose aldosterone's deleterious cardiovascular effects) improve cardiac structure/function, independently blood pressure (BP), in patients with/at risk type 2 diabetes (a population at heart failure). Methods A subsample participants our double‐blind, randomized, factorial‐design...
Diabetes and hypertension increase arterial stiffness cardiovascular events in all societies studied so far; sub-Saharan African studies are sparse. We investigated factors affecting function Ghanaians with diabetes, hypertension, both or neither. Testing the hypothesis that would progressively from controls to multiply affected patients, 270 participants were stratified into those diabetes only, both, without either. Cardio-ankle vascular index (CAVI), heart–ankle pulse wave velocity...
Aims Dietary nitrate from sources such as beetroot juice lowers blood pressure (BP) via the nitrate–nitrite–nitric oxide (NO) pathway. However, NO and nitrite are inactivated reoxidation to nitrate, potentially limiting their activity. Cytochrome P450‐3A4 inhibition with troleandomycin prevents re‐oxidation in rodent liver. Grapefruit contains CYP3A4 inhibitor furanocoumarin. We therefore hypothesized that grapefruit would enhance BP‐lowering by maintaining circulating [nitrite]. Methods...
Interesterified (IE) fats are widely used in place of trans fats; however, little is known about their metabolism. To test the impact a commonly consumed IE compared with non-IE equivalent fat on vivo postprandial and vitro lipid metabolism, reference oil [rapeseed (RO)]. A double-blinded, 3-phase crossover, randomized controlled trial was performed healthy adults (n = 20) aged 45-75 y. Postprandial plasma triacylglycerol lipoprotein responses (including stable isotope tracing) to meal (50 g...
Most comparisons of arterial stiffness between ethnic groups focus on pulse wave velocity. This study used the cardio-ankle vascular index (CAVI) in European compared to Japanese individuals investigate how cardiovascular risk factors affect aging across geographic regions.Four hundred and ninety-four 1044 underwent measurements CAVI, blood pressure information factors. Both datasets included with 0-5 factors.Average CAVI was higher than group every age category, significant differences up...
Raised vascular function measures are associated with adverse maternal and perinatal outcomes in low-risk pregnancy. This study aimed to evaluate the association between longitudinal parameters outcome pregnant women chronic hypertension, assess whether these vary according baseline such as black ethnicity.This was a nested cohort of hypertension singleton pregnancy recruited PANDA (Pregnancy And hypertension: NifeDipine vs lAbetalol antihypertensive treatment) at one three UK maternity...
Industrially generated trans-fats have been linked with cardiovascular disease (CVD) and thus replaced by interesterified (IE) fats, in foods. Interesterification rearranges fatty acids on the glycerol backbone of a triacylglycerol molecule. However, impact IE fat health is unknown. We recently reported differences lipid absorption kinetics between rapeseed oil (RO). Here, we investigated mechanisms underpinning digestion same muffins baked using an fat, non-IE [with acid composition] (RO)...
The majority of university curricula for health professionals does not incorporate courses on human nutrition and its links with planetary health. This primarily applies to medical pharmacy students, who have important counselling roles are at the forefront public To address this issue, EIT Food recently launched an online course nutrition, health, sustainability. Learners were able provide feedback through end-of-course survey social interaction FutureLearn platform. was very well attended...
Anthocyanins have poor bioavailability, but the factors affecting this remain unclear. Uptake into cells could impact bioavailability; therefore, understanding anthocyanin uptake is pivotal to improve their bioavailability and reveal mechanism for uptake. This study aimed investigate effect of structure, pH glucose on anthocyanins by Caco-2 cells. Anthocyanin extract from strawberry red grape at 10 or 20 µM was added toxicity firstly examined ensure same cell viability. The carried out 7 6.5...