A5072246025- Reproductive Physiology in Livestock
- Blood Pressure and Hypertension Studies
- Genetic and phenotypic traits in livestock
- Ruminant Nutrition and Digestive Physiology
- Inflammatory mediators and NSAID effects
- Hormonal Regulation and Hypertension
- Effects of Environmental Stressors on Livestock
- Health Systems, Economic Evaluations, Quality of Life
- Drug-Induced Adverse Reactions
- Lipoproteins and Cardiovascular Health
- Helicobacter pylori-related gastroenterology studies
- Animal Behavior and Welfare Studies
- Cardiovascular Health and Disease Prevention
- Human-Animal Interaction Studies
- Pharmaceutical Practices and Patient Outcomes
- Sodium Intake and Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Economics and Policy
- Milk Quality and Mastitis in Dairy Cows
- Growth Hormone and Insulin-like Growth Factors
- Multiple Sclerosis Research Studies
- Probiotics and Fermented Foods
- Asthma and respiratory diseases
- Proteins in Food Systems
- Fatty Acid Research and Health
University of Dundee
2015-2024
Ninewells Hospital
2002-2021
Molecular Medicine Ireland
2004-2018
National Hospital for Neurology and Neurosurgery
2017
University of Southern California
2017
University College London
2017
University of California, San Francisco
2017
University of Basel
2017
Institute of Neuroimmunology of the Slovak Academy of Sciences
2017
Queen Mary University of London
2017
Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses that most often caused by excessive sodium retention, and spironolactone would therefore be superior non-diuretic add-on drugs at lowering blood pressure.In this double-blind, placebo-controlled, crossover trial, we enrolled aged 18-79 years seated clinic systolic pressure 140 mm Hg or greater (or ≥135 diabetes) home (18 readings over 4 days) 130 greater, despite least 3 months...
<h3>Objectives</h3> To estimate the incidence and prevalence of multiple sclerosis (MS) by age describe secular trends geographic variations within UK over 20-year period between 1990 2010 hence to provide updated information on impact MS throughout UK. <h3>Design</h3> A descriptive study. <h3>Setting</h3> The study was carried out in General Practice Research Database (GPRD), a primary care database representative population. <h3>Main outcome measures</h3> Incidence per 100 000 Secular...
In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess mechanisms underlying this superiority and pathogenesis hypertension.PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary secondary care sites in 314 patients with hypertension. Patients were given 12 weeks once daily treatment each placebo, 25-50 mg, bisoprolol 5-10 doxazosin 4-8 mg...
<h3>Objective:</h3> To investigate a potential effect of riluzole on serum neurofilaments (Nf) compared to placebo and the relationship between longitudinal clinical MRI outcomes Nf levels. <h3>Methods:</h3> Serum samples were obtained from participants enrolled in randomized double-blind trial neuroprotection with vs as an add-on weekly interferon-β (IFN-β)–1a IM initiated 3 months after randomization. measurements performed by ELISA electrochemiluminescence immunoassay. <h3>Results:</h3>...
<h3>Abstract</h3> <b>Objectives:</b> To determine the profile of risk upper gastrointestinal toxicity during continuous treatment with, and after cessation of, non-steroidal anti-inflammatory drugs. <b>Design:</b> Cohort study with a prospectively constructed, population based, record linkage database containing details exposure to all community dispensed drugs also admissions hospital for diagnoses. <b>Setting:</b> The Tayside, Scotland. <b>Subjects:</b> 52 293 subjects aged 50 over who...
To obtain information on the physiological mechanisms controlling partition of dietary energy between body weight and milk production in lactating cattle, concentrations hormones (prolactin, growth hormone, insulin thyroxine) metabolites (glucose, non-esterified fatty acids, β-hydroxybutyric acid l-lactic acid) plasma obtained from eight high-yielding seven low-yielding cows, matched for diet stage lactation, were compared. Blood samples taken via a jugular catheter, throughout four 48 h...
To perform a randomized, double-blind, crossover clinical trial of diclofenac + misoprostol versus acetaminophen in ambulatory patients with osteoarthritis the hip or knee.Patients 12 care settings were eligible if they age >40 years and had Kellgren/Lawrence radiographic grade 2-4 knee score > =30 mm on 100-mm visual analog pain scale. Patients randomized to one two groups, 75 mg 200 microg twice daily 1,000 4 times (each for 6 weeks), then crossed over other treatment weeks. A placebo was...
Potassium depletion by thiazide diuretics is associated with a rise in blood glucose. We assessed whether addition or substitution of potassium-sparing diuretic, amiloride, to treatment can prevent glucose intolerance and improve pressure control.We did parallel-group, randomised, double-blind trial 11 secondary two primary care sites the UK. Eligible patients were aged 18-80 years; had clinic systolic 140 mm Hg higher home 130 mmHg on permitted background drugs angiotensin-converting enzyme...
Background Guidelines for hypertension vary in their preference initial combination therapy or monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches. Methods Results We performed a 1‐year, double‐blind, randomized controlled trial 605 untreated patients aged 18 to 79 years with systolic blood pressure ( BP ) ≥150 mm Hg diastolic ≥95 Hg. In phase 1 (weeks 0–16), were randomly assigned monotherapy (losartan 50–100 mg...
Timing drug administration to endogenous circadian rhythms may enhance treatment efficacy. In the Chronotype sub-study of Treatment in Morning versus Evening (TIME) clinical trial we examined whether timing usual antihypertensive medications according patient chronotype (a behavioural marker personal rhythm) influence cardiovascular outcomes.
Background: There are considerable variations in estimates of the number emergency upper gastrointestinal admissions per annum which attributable to nonsteroidal anti‐inflammatory drug (NSAID) use. Aim : To obtain a more accurate estimate these UK. Methods A retrospective survey case notes all for disease (‘Cases’) two English District General Hospitals with combined catchment population 550000. Records community deaths attributed diagnoses (with same ICD codes) were also surveyed. Matched...
ABSTRACT Six alternative lactation curves were derived by considering the proportional rates of change in milk yield during lactation. Experimental data showed that do not necessarily fall to a constant value mid and late This accounts for systematic lack fit reported several authors using derivative incomplete gamma function, whose second has horizontal asymptote. Curves derivatives are restricted this way described patterns first third animals more closely. Some statistical properties...
Summary The aggregation of casein micelles in milk by the action rennet, examined electron microscopy and viscometry, was correlated with visually-observed coagulation. spatial relationships between were quantified from measurements made on micrographs. Aggregation did not start until about 60% rennet-clotting time, when enzymic almost complete. tended to form chains which then linked into a loose network. This became more extensive time as average size aggregates increased. By clotting most...
Summary Twenty-four Friesian cows were allocated to one of four diets for weeks 3–14 lactation following 2 on a common diet. The (kg air-dry feed/day) 7–2 kg hay and 10·8 either starchy or fibrous concentrates (60S 60F) 3·5 14·0 (80S 80F). Rumen samples taken by stomach tube in 10 12 the digestibility was measured with per treatment during 13 14. same feeds also sheep at maintenance. principal carbohydrate constituents barley, wheat cassava citrus pulp, sugar-beet pulp feed concentrates....
This study updated our knowledge of UK primary care neuropathic pain incidence rates and prescribing practices. Patients with a first diagnosis post-herpetic neuralgia (PHN), painful diabetic neuropathy (PDN) or phantom limb (PLP) were identified from the General Practice Research Database (2006 – 2010) calculated. Prescription records searched for treatments these conditions duration daily dose estimated first-line subsequent treatment regimens. Recording back post-operative was...
Previous studies have suggested that some pet dogs respond to their owners' hypoglycaemic state. Here, we show trained glycaemia alert placed with clients living diabetes afford significant improvements owner well-being. We investigated whether reliably state, and owners experience facilitated tightened glycaemic control, wider psychosocial benefits. Since obtaining dog, all seventeen studied reported positive effects including reduced paramedic call outs, decreased unconscious episodes...
1. The present paper reports the effects of dietary modifications on diurnal pattern concentrations certain metabolites and hormones in peripheral blood lactating dairy cows. cows were given fixed rations hay high-cereal concentrates proportions 30:70 or 10:90 (w/w). either two six equal meals daily; was twice daily. 2. Previous same experiment had shown that milk-fat yield concentration reduced by increasing proportion diet increased more frequent feeding concentrates. These changes could...
1. Circulating concentrations of some hormones and metabolites nitrogen balance were measured in lactating beef dairy cows given daily injections growth hormone (GH) compared to values before injection. Changes milk yield composition recorded these additional injected with GH fragments. 2. GH, but not fragments, raised while did change. injection caused a large, rapid increase the level blood slower, smaller increases insulin, prolactin thyroxine. Blood metabolite levels unaltered except for...
<h3>Background:</h3> Influenza and pneumococcal vaccination are recommended in patients with chronic obstructive pulmonary disease (COPD). A recent study from Tayside found a reduced risk of all-cause mortality COPD. The Health Improvement Network (THIN) database was used to test this hypothesis different data source. <h3>Methods:</h3> THIN searched for Vaccination status against <i>Pneumococcus</i> the annual influenza were determined. Mortality rates calculated periods December March April...
<b>Objective </b>To investigate whether exposure to spironolactone treatment affects the risk of incident breast cancer in women over 55 years age. <b>Design</b> Retrospective, matched cohort study. <b>Setting</b> General Practice Research Database, a primary care anonymised database representative general population United Kingdom. <b>Participants</b> 1 290 625 female patients, older than and with no history cancer, from 557 practices total follow-up time 8.4 million patient years. We...
Lamotrigine trial in SPMS was a randomised control to assess whether partial blockade of sodium channels has neuroprotective effect. The current study an additional investigate the value neurofilament (NfH) and other biomarkers predicting prognosis and/or response treatment.SPMS patients who attended NHNN or Royal Free Hospital, UK, eligible for inclusion were invited participate biomarker study. Primary outcome lamotrigine would significantly reduce detectable serum NfH at 0-12, 12-24 0-24...