A5045796083- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Advanced X-ray and CT Imaging
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Energy and Environment Impacts
- Climate Change and Health Impacts
- Cardiovascular Effects of Exercise
- Air Quality and Health Impacts
- Trace Elements in Health
- Cardiac Ischemia and Reperfusion
- Blood donation and transfusion practices
- Health, Environment, Cognitive Aging
- Sarcoidosis and Beryllium Toxicity Research
- IgG4-Related and Inflammatory Diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac tumors and thrombi
- Cardiovascular Health and Risk Factors
- Vector-borne infectious diseases
- Blood transfusion and management
- Radiomics and Machine Learning in Medical Imaging
University of Edinburgh
2013-2024
Edinburgh College
2024
Edinburgh Royal Infirmary
2020-2023
Icahn School of Medicine at Mount Sinai
2020
British Heart Foundation
2018-2020
Universitat Autònoma de Barcelona
2019
Waikato Hospital
2015-2017
St George's, University of London
2011-2013
NHS Lothian
2013
Lung Institute
2013
Acute stress-induced (takotsubo) cardiomyopathy can result in a heart failure phenotype with prognosis comparable that of myocardial infarction. In this study, we hypothesized inflammation is central to the pathophysiology and natural history takotsubo cardiomyopathy.In multicenter prospectively recruited 55 patients 51 age-, sex-, comorbidity-matched control subjects. During index event at 5-month follow-up, underwent multiparametric cardiac magnetic resonance imaging, including ultrasmall...
The sudden death of young individuals is commonly attributed to inherited cardiac disorders, and familial evaluation advocated. identification pathognomonic histopathologic findings, or the absence pathology (sudden arrhythmic syndrome [SADS]) at postmortem, directs targeting structural disorders primary arrhythmogenic syndromes, respectively. In a proportion autopsies, abnormalities uncertain significance are reported. We explored hypothesis that such deaths represent SADS.Families (n=340)...
Objective First-phase ejection fraction (EF1) is a novel measure of early left ventricular systolic dysfunction. We investigated determinants EF1 and its prognostic value in aortic stenosis. Methods was measured retrospectively participants an echocardiography/cardiovascular magnetic resonance cohort study which recruited patients with stenosis (peak velocity ≥2 m/s) between 2012 2014. Linear regression models were constructed to examine variables associated EF1. Cox proportional hazards...
Cardiac MR is widely used to diagnose cardiac amyloid, but cannot differentiate AL and ATTR subtypes: an important distinction given their differing treatments prognoses. We PET/MR imaging quantify myocardial uptake of 18F-fluoride in amyloid patients, as well participants with aortic stenosis age/sex-matched controls.
Manganese-enhanced MRI (MEMRI) has the potential to identify viable myocardium and quantify calcium influx handling. Two distinct manganese contrast media have been developed for clinical application, mangafodipir EVP1001-1, employing different strategies mitigate against adverse effects resulting from calcium-channel agonism. Mangafodipir delivers ions as a chelate, EVP1001-1 coadministers gluconate. Using myocardial T1 mapping, we aimed explore chelated nonchelated agents, their mechanism...
CaseThis case is of a 52-year-old lady, who presented with 7-day history headache associated nausea and vomiting.On physical examination, she was apyrexial, neurological examination unremarkable.She had seropositive rheumatoid arthritis diagnosed 20 years previously.During this time, been treated multiple anti-rheumatic drugs, including Gold, Sulphasalazine, Methotrexate, Penicillamine Leflunomide, in addition to several arthroplasties arthrodeses.No extra-articular manifestations disease...
To use global longitudinal strain (GLS) as a marker of left ventricular decompensation in aortic stenosis and to investigate the relationship GLS measured with cardiac MRI markers myocardial fibrosis, symptom development, remodeling, clinical outcomes.Patients healthy control subjects were assessed. was assessed by using feature tracking, diffuse fibrosis T1 mapping, replacement late gadolinium enhancement. Follow-up prospective for primary endpoint all-cause mortality.GLS reduced (n = 159)...
The aim of this study is to quantify altered myocardial calcium handling in non-ischaemic cardiomyopathy using magnetic resonance imaging.
Abstract Aim To investigate myocardial calcium handling using manganese-enhanced magnetic resonance imaging in patients with type 2 diabetes the presence and absence of heart failure reduced ejection fraction. Methods In a prospective case-control study, 14 healthy volunteers, 24 normal left ventricular function (early stages diabetic cardiomyopathy), 20 fraction, both fraction (late cardiomyopathy) underwent cardiac imaging. Results Mean manganese uptake was 8.3±1.3 mL/100 g tissue/min...
Abstract Manganese-enhanced magnetic resonance imaging can provide a surrogate measure of myocardial calcium handling. Its repeatability and reproducibility are currently unknown. Sixty-eight participants: 20 healthy volunteers, with acute infarction, 18 hypertrophic 10 non-ischemic dilated cardiomyopathy underwent manganese-enhanced imaging. Ten volunteers were re-scanned at 3 months. Native T1 values manganese uptake assessed for intra inter-observer repeatability. Scan-rescan was in ten...
<h3>Background</h3> Investigation of blood relatives for evidence an inherited cardiac condition is advocated following unexplained sudden death (SCD). <h3>Aim</h3> We determined the diagnostic yield exercise tolerance testing (ETT) in investigation conditions familial premature SCD. <h3>Methods</h3> Between 2006 and 2010, we evaluated 308 148 SCD victims, who completed at least 3 min Bruce protocol. ETTs were analysed for: QT prolongation; Brugada type 1 pattern; ST depression: pressure...
Background.Delayed-enhancement magnetic resonance imaging (DEMRI) using gadolinium-based contrast media overestimates infarct size acutely.Furthermore, DEMRI can only indirectly assess myocardial viability by quantifying scar burden.Manganese, an essential trace element and paramagnetic calcium-analogue, defines viable myocardium directly functional calcium-handling (administered as chelated manganese dipyridoxyl diphosphate, Mn-DPDP).Our previous preclinical work demonstrated...
<h3>Introduction</h3> Cardiac MR is widely used to diagnose cardiac amyloid but cannot differentiate AL and ATTR subtypes: an important distinction given their differing treatments prognoses. We PET/MR imaging quantify myocardial uptake of 18F-fluoride in patients as well participants with aortic stenosis age/sex matched controls (both negative controls). <h3>Methods</h3> In this prospective multi-centre study, were recruited Edinburgh New York underwent imaging. Standardised volumes...
Purpose: Myocardial inflammation following infarction or coronary bypass graft (CABG) surgery exerts detrimental effects on ventricular remodelling and function. “Ultrasmall superparamagnetic particles of iron-oxide” (USPIOs) are internalised by inflammatory cells, shorten T2* decay times during magnetic resonance imaging (MRI). The aim the study was to assess whether USPIOs could be used measure in vivo myocardial cellular after ST-elevation (STEMI) CABG surgery. Methods: Patients underwent...
Background: Hybrid magnetic resonance / positron emission tomography (MR/PET) offers combined functional metabolic imaging with advanced tissue characterisation.To date, the published literature on MR/PET in aortic stenosis (AS) comprises just a single patient.Purpose: To investigate utility of patients AS and whether radiotracer 18F sodium fluoride (18F-NaF) can measure calcification activity valve detect co-existent cardiac transthyretin (TTR) amyloidosis myocardium.Methods: Patients...
Abstract Background Delayed-enhancement magnetic resonance imaging (DEMRI) with gadolinium detects macroscopic myocardial fibrosis, but does not directly assess function. Manganese, a paramagnetic calcium-analogue, enables direct dynamic assessment myocyte calcium handling and is potential early marker of dysfunction. We have previously demonstrated manganese-enhanced MRI (MEMRI) can detect altered calcium-handling in remote remodelling myocardium rodent infarct model. Purpose To evaluate...