A5013344724- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Peptidase Inhibition and Analysis
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Chemotherapy-induced cardiotoxicity and mitigation
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Fibrosis and Remodeling
- Innovations in Medical Education
- Medical Imaging Techniques and Applications
- Acute Myocardial Infarction Research
- Protease and Inhibitor Mechanisms
- Health and Medical Research Impacts
- Acute Ischemic Stroke Management
- Diversity and Career in Medicine
- Aortic Disease and Treatment Approaches
- Neuroendocrine Tumor Research Advances
- Antiplatelet Therapy and Cardiovascular Diseases
- Otolaryngology and Infectious Diseases
- Clinical practice guidelines implementation
- Neuroblastoma Research and Treatments
- Coronary Interventions and Diagnostics
University of Edinburgh
2022-2025
Edinburgh College
2024-2025
British Heart Foundation
2023-2025
Edinburgh Royal Infirmary
2023-2024
University of Iowa Hospitals and Clinics
2024
Cedars-Sinai Medical Center
2024
Bournemouth University
2021-2022
Dorset County Hospital
2020
University Hospital Southampton NHS Foundation Trust
2019
Essex Cardiothoracic Centre
2019
Myocardial fibrosis is a key healing response after myocardial infarction driven by activated fibroblasts. Gallium-68-labeled fibroblast activation protein inhibitor ([68Ga]-FAPI) novel positron-emitting radiotracer that binds The aim of this study was to investigate the intensity, distribution, and time-course acute infarction. A total 40 patients with underwent hybrid [68Ga]FAPI-46 positron emission tomography cardiac magnetic resonance were compared matched control subjects (n = 19) those...
Abstract Background The myocardium is in direct contact with the epicardial fat. We hypothesized that surrounding cardiac adipose tissue might influence left ventricular (LV) structure and remodeling patients aortic stenosis. This study aimed to investigate association between pericardial fat volume markers of function myocardial fibrosis Method studied subjects were participants CMRAS-cohort included stenosis healthy controls. All underwent comprehensive echocardiography magnetic resonance...
Abstract Introduction In patients with aortic stenosis, fibrosis is a common pathophysiological feature of leaflet thickening as well left ventricular decompensation it transitions from hypertrophy to heart failure. Valvular can be quantified by contrast-enhanced computed tomography, and myocardial late gadolinium enhancement on magnetic resonance imaging, but neither detect the activity extracellular matrix remodelling. Gallium-68 Fibroblast Activation Protein Inhibitor (68Ga-FAPI) binds...
<h3>Introduction</h3> Carcinoid heart disease is characterised by thickening and dysfunction of the right sided valves due to endocardial fibrous tissue deposition, eventually leading failure. <sup>68</sup>Gallium-labelled fibroblast activation protein inhibitor (<sup>68</sup>Ga-FAPI) a novel radiotracer that binds specifically activated fibroblasts. We used <sup>68</sup>Ga-FAPI investigate role fibroblasts in these patients. <h3>Methods</h3> 10 patients with active carcinoid syndrome were...
Abstract Background Novel molecular positron emission tomography (PET) assessments of fibrosis are now available but have not been compared directly to cardiovascular magnetic resonance (CMR), the current reference standard for myocardial scar assessment. Using 68Gallium-fibroblast activation protein inhibitor (FAPI), a radiotracer that binds activated fibroblasts, we CMR and PET following ST-elevation infarction. Methods Hybrid 68Ga-FAPI-46 PET/MR with gadolinium-based contrast agent was...
Abstract Introduction Progressive leaflet thickening in aortic stenosis is driven by fibrosis and calcification. Recent studies have quantified valvular using contrast enhanced computed tomography (CT) techniques, with the combined fibro-calcific score correlating better disease severity than CT-calcium scoring alone. However, understanding activity within valve may allow detection of prior to extracellular matrix remodelling progressive thickening. Gallium68 Fibroblast Activation Protein...
Abstract Introduction Atrial fibrosis is a key factor in the development of atrial fibrillation (AF)(1). 68Gallium-labelled fibroblast activation protein inhibitor (68Ga-FAPI) binds to activated fibroblasts, enabling tracking and activity (2). Methods Participants with heart failure preserved ejection fraction (HFPEF), aortic stenosis (AS) healthy volunteers underwent 68Ga-FAPI PET, cardiac magnetic resonance (CMR) imaging echocardiography. 2 analysers were blinded AF status participants....
Background: Bicuspid aortic valve is associated with thoracic aortopathy many patients suffering dissection below the diameter threshold for prophylactic replacement surgery. In aortopathy, wall media initially undergoes increasing microcalcification due to elastin fibre fragmentation but disease progression, degradation leads loss of microcalcification. 18 F-Sodium fluoride positron emission tomography (PET) a non-invasive method detecting arterial that has been successfully used in...
Activated fibroblasts drive leaflet thickening and left ventricular decompensation in aortic stenosis. Gallium-68 Fibroblast Activation Protein Inhibitor (68Ga-FAPI) binds to these key effector cells, provides a readout of fibroblast activation. We aimed describe the role activated patients with stenosis vivo using 68Ga-FAPI. In prospective observational study, control subjects underwent echocardiography, 68Ga-FAPI PET, CT, MRI. Valvular myocardial uptake was quantified maximal standardised...
Abstract Introduction Carcinoid heart disease is a rare affecting the right sided valves (1) while anthracycline cardiotoxicity dreaded sequelae of common chemotherapeutic agent that can occur early or even years after exposure (2). Activated fibroblasts, key factor in these diseases, be imaged with 68Gallium-fibroblast activation protein inhibitor (68Ga-FAPI). Method 12 patients carcinoid syndrome, previous and 10 healthy volunteers underwent hybrid 68Ga-FAPI positron emission tomography...
Abstract Aim To investigate myocardial calcium handling using manganese-enhanced magnetic resonance imaging in patients with type 2 diabetes the presence and absence of heart failure reduced ejection fraction. Methods In a prospective case-control study, 14 healthy volunteers, 24 normal left ventricular function (early stages diabetic cardiomyopathy), 20 fraction, both fraction (late cardiomyopathy) underwent cardiac imaging. Results Mean manganese uptake was 8.3±1.3 mL/100 g tissue/min...
18F-GP1 is a novel highly specific radiotracer that binds to activated platelets and thrombus. We aimed establish the observer repeatability of coronary, carotid cerebral uptake in patients presenting with acute myocardial infarction or ischaemic stroke. Forty-three stroke underwent hybrid positron emission tomography (PET) computed (CT) angiography. Qualitative quantitative assessment was performed on coronary arteries, arteries brain parenchyma. had excellent intraobserver interobserver...
Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): NA Background Endocarditis is a complex condition with high rates morbidity and mortality. The clinical presentation highly variable diagnosis may be difficult. ESC guidelines include modified diagnostic criteria utilising both Duke multimodality imaging techniques in order to improve sensitivity. A Multidisciplinary Team (MDT) recommended patient care has been shown reduce 1 year We have...
Ticagrelor is a potent and orally active P2Y12 inhibitor. has been extensively tested in Phase II III trials patients with coronary artery disease. The pharmacokinetics pharmacodynamics of ticagrelor result more rapid effective inhibition platelet activation compared other inhibitors. This resulted reduction recurrent major cardiovascular events initial randomized controls comparing clopidogrel. More recently, clinical have investigated the use stable disease high residual risk thrombotic...
We sought to evaluate the potential impact of racial difference (Asians vs Caucasians) on clinical usefulness pressure recovery (PR) adjustment for preventing discordant aortic stenosis (AS) grading in patients with severe AS.Data from 1450 (mean age, 70.2±10.6 years; 290 (20%) Caucasians; valve area (AVA), 0.77±0.26 cm2) were retrospectively analysed. PR-adjusted AVA was calculated using a validated equation. Discordant AS defined as <1.0 cm2 and mean gradient <40 mm Hg. The frequency...