A5055366797- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Adolescent and Pediatric Healthcare
- Dialysis and Renal Disease Management
- Global Health Care Issues
- Healthcare Policy and Management
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Peripheral Artery Disease Management
- Neonatal Health and Biochemistry
- Growth Hormone and Insulin-like Growth Factors
- Chronic Kidney Disease and Diabetes
- Organ Donation and Transplantation
- Pregnancy and Medication Impact
- Organ Transplantation Techniques and Outcomes
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Ureteral procedures and complications
- Pharmacological Effects and Toxicity Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Coronary Interventions and Diagnostics
- Ethics and Legal Issues in Pediatric Healthcare
- Complement system in diseases
- Muscle metabolism and nutrition
Royal Hospital for Children
2015-2024
Dorset County Hospital NHS Foundation Trust
2024
Gilead Sciences (United States)
2021-2024
NHS Greater Glasgow and Clyde
2017-2022
Glasgow Royal Infirmary
2022
Gilead Sciences (Australia)
2020
University Hospitals Coventry and Warwickshire NHS Trust
2019
Queen Elizabeth II Hospital
2018
European Society for Paediatric Oncology
2018
Næstved Sygehus
2017
Minimizing steroid exposure in pediatric renal transplant recipients can improve linear growth and reduce metabolic disorders. This randomized multicenter study investigated the impact of early withdrawal on mean change height standard deviation score (SDS) safety efficacy two immunosuppressive regimens during first 6 months after transplantation. Children received tacrolimus, MMF, doses daclizumab steroids until day 4 (TAC/MMF/DAC, n = 98) or MMF standard-dose (TAC/MMF/STR, 98). Mean SDS...
Primary membranoproliferative GN, including complement 3 (C3) glomerulopathy, is a rare, untreatable kidney disease characterized by glomerular deposition. Complement gene mutations can cause familial C3 and studies have reported rare variants in genes nonfamilial primary GN.We analyzed whole-genome sequence data from 165 GN cases 10,250 individuals without the condition (controls) as part of National Institutes Health Research BioResource-Rare Diseases Study. We examined copy number, common...
In Brief Background Corticosteroid withdrawal (CW) after pediatric kidney transplantation potentially improves growth while avoiding metabolic and other adverse events. We have recently reported the results of a 196 subject randomized controlled trial comparing early CW (tacrolimus, mycophenolate mofetil (MMF), daclizumab, corticosteroids until day 4) with tacrolimus, MMF, corticosteroid continuation (CC). At 6 months, subjects showed better no impact on acute rejection or graft survival (Am...
To evaluate the efficacy (height velocity (HV), change in height standard deviation score (delta HSDS)), and safety (glomerular filtration rate (GFR), incidence of rejection, calcium glucose metabolism) recombinant human growth hormone (rhGH) treatment after renal transplantation.A two year randomised controlled trial.Fifteen prepubertal seven pubertal children: mean (SD) age, 13.0 (2.6) 15.2 (2.4) years, respectively; GFR, 51 (30) 48 (17) ml/min/1.73 m2, respectively. Six three children...
Background. Little is known about the group of children on renal replacement therapy (RRT) who reach age 18 years and are transferred from paediatric to adult nephrology services. The aim this study was describe patient demographics, primary diseases, treatment history determine risk factors for mortality these young adults started RRT in childhood. Methods. We included 1777 had during childhood turned between 1985 2004 nine European registries submitting data ERA-EDTA Registry. chi-square...
Background and objectives Membranoproliferative GN C3 glomerulopathy are rare overlapping disorders associated with dysregulation of the alternative complement pathway. Specific etiologic data for pediatric membranoproliferative GN/C3 lacking, outcome based on retrospective studies without data. Design, setting, participants, & measurements A total 80 prevalent patients underwent detailed phenotyping long-term follow-up within National Registry Rare Kidney Diseases (RaDaR). Risk factors...
Background. Improved management of growth impairment might have resulted in less retardation after pediatric kidney transplantation (KT) over time. We aimed to analyze recent longitudinal data KT comparison previous eras, its determinants, and the association with transplant outcome a large cohort transplanted children using from European Society for Paediatric Nephrology/European Renal Association Dialysis Transplant Registry. Methods. A total 3492 patients before 18 years 1990 2012 were...
In children with corticosteroid-sensitive nephrotic syndrome, many relapses are triggered by upper respiratory tract infections. Four small studies found that administration of daily low-dose prednisolone for 5 to 7 days at the time an infection reduced risk relapse, but generalizability their findings is limited location and selection study population.To investigate use treatment infection-related relapses.This double-blind, placebo-controlled randomized clinical trial (Prednisolone in...
Remdesivir decreases the risk of SARS-CoV-2 infection progressing to severe disease in adults. This study evaluated remdesivir safety and pharmacokinetics infants children.
Relapses of childhood steroid-sensitive nephrotic syndrome (SSNS) are treated with a 4- to 8-week course high-dose oral prednisolone, which may be associated significant adverse effects. There is clear association between upper respiratory tract infection (URTI) and relapse development. Previous studies in developing nations have suggested that introducing 5- 7-day daily prednisolone during an URTI prevent the need for treatment prednisolone. The aim PREDNOS 2 evaluate effectiveness 6-day...
Abstract Corticotropin‐releasing hormone (CRH) has multiple roles in coordinating the behavioral and endocrine responses to a host of environmental challenges, including social stressors. In present study we evaluated role CRH mediating moderate stressor Wied's black tufted‐eared marmosets ( Callithrix kuhlii ). Male female (n=14) were administered antalarmin (a selective CRH‐1 receptor antagonist; 50µg/kg, p.o.) or vehicle blind, counterbalanced, crossover design. One hr after treatment,...
Aims: To describe the demographics of paediatric RRT population under age 16 years in UK and to analyse changes demography with time. Methods: Data were collected from all 13 renal centres within UK. A series cross-sectional longitudinal analyses performed patients. Results: total 856 children young people 18 ERF receiving treatment at nephrology 2011. At census date, 80.1% had a functioning transplant, 10.5% peritoneal dialysis (PD) 9.4% haemodialysis (HD). In patients aged <16...
A total of 941 children and young people aged ,18 years with established renal failure (ERF) were receiving treatment at paediatric nephrology centres in 2015.. At the census date (31st December 2015), 75.3% prevalent patients ,16 had a functioning kidney transplant, 13.0% haemodialysis (HD) 11.7% peritoneal dialysis (PD). .In years, prevalence ERF was 62.7 per million age related population (pmarp) incidence 10.2 pmarp.. The most common primary diagnosis dysplasia + reflux, present 34.7%...