A5049512715- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Metabolism and Genetic Disorders
- Pregnancy and Medication Impact
- Adolescent and Pediatric Healthcare
- Central Venous Catheters and Hemodialysis
- Pharmacological Effects and Toxicity Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Nutrition and Health
- Organ Donation and Transplantation
- Nephrotoxicity and Medicinal Plants
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Muscle and Compartmental Disorders
- Clinical Nutrition and Gastroenterology
- Liver Disease and Transplantation
- Electrolyte and hormonal disorders
- Renal and related cancers
- Growth Hormone and Insulin-like Growth Factors
- Urological Disorders and Treatments
- Ion Transport and Channel Regulation
- Ocular Diseases and Behçet’s Syndrome
Helsinki University Hospital
1998-2019
Helsinki Children's Hospital
1985-2019
University of Helsinki
2007-2018
Children's Hospital
2015
Vaasa Central Hospital
2012
Finnish Institute for Health and Welfare
2012
Tampere University
1997
Very young children with chronic kidney disease often have difficulty maintaining adequate nutrition, which contributes to the high prevalence of short stature in this population. Characteristics dialysis prescription and supplemental feeding via a nasogastric (NG) tube or gastrostomy may improve growth, but is not well understood. Here, we analyzed data from 153 18 countries who commenced peritoneal at <24 months age. From diagnosis last observation, 57 patients were fed on demand, 54 by NG...
Abstract: Patient and graft survival rates of pediatric renal transplant recipients are currently excellent, but there few reports regarding the long‐term neurodevelopmental outcome after transplantation (Tx) in early childhood. Children with failure from infancy would be expected to have a less favorable developmental prognosis. We report 33 school‐age children transplanted between 1987 1995 when < 5 yr age. prospectively performed neurological examination, magnetic resonance imaging...
Congenital nephrotic syndrome (CNS) can be caused by neonatal infections, renal diseases which exceptionally occur in early infancy and syndromes with a histology of DMS. The most common CNS is the Finnish-type (CNF), an autosomal recessively inherited disease characterized intrauterine onset massive proteinuria. CNF gene has been localized to long arm chromosome 19, but pathogenesis remains unclear. Forty-six patients have treated at our institution. diagnosis was based on family history,...
Psychosocial adjustment and quality of life has been reported good in children after a successful renal transplantation (Tx). There are, however, few reports using standardized methods evaluating these issues, particularly small children. We investigated the psychosocial 32 at school age (mean 9.6 +/- 1.6), who had received Tx under 5 yr, Achenbach Child Behavior Checklist with data collected from both parents (CBCL) teachers (CBCL-TRF). Health-related (HRQOL) was assessed by interviewing...
Outcome of renal function and blood pressure (BP) at early middle age was clarified in patients treated for vesicoureteral reflux (VUR) during childhood.Information available from 147 (55%) 267 non-obstructive VUR any grade. Twelve had died kidney-related conditions eight gone into terminal uraemia. A total 127 participated the study.The mean participants 41 years. No signs scars were detected by ultrasound examination 53 (42%) subjects. Unilateral scarring seen 44 (35%) bilateral 30 (24%)...
We investigated the influence of human milk protein and medium-chain triglyceride supplementations feedings on growth very low birth weight infants during their first weeks life. A group 44 preterm with weights less than 1,520 g a mean gestational age 30.3 was randomly divided into four groups to receive plain or supplemented (0.9 g/dL), triglycerides (1 both. The oil supplementation did not these infants. given supplementary gained faster 4 6 those without (18.5 +/- 0.7 v 15.1 0.6 g/kg/d;...
Background. Little is known about the group of children on renal replacement therapy (RRT) who reach age 18 years and are transferred from paediatric to adult nephrology services. The aim this study was describe patient demographics, primary diseases, treatment history determine risk factors for mortality these young adults started RRT in childhood. Methods. We included 1777 had during childhood turned between 1985 2004 nine European registries submitting data ERA-EDTA Registry. chi-square...
Background. Although results of peritoneal dialysis (PD) in small children have improved during recent years, the youngest poorer growth, more infections and higher mortality than do older children. Methods. In this retrospective study, we analysed patient records all under age 2 treated with continuous (CPD) between 1995 2000 Finland. Diagnoses leading to renal failure these 23 were congenital nephrotic syndrome Finnish type (13), polycystic kidney disease (4), a urethral valve (3),...
The basis for lifelong bone health is established in childhood and adolescence. Whereas pediatric renal transplant (RTx) patients are at risk impaired mass gain fractures, scarce data on this subject available. We performed a cross-sectional longitudinal study of national cohort 106 RTx (median age, 12.6 yr; median follow-up, 5.1 yr after RTx). underwent clinical evaluation, DXA BMD, spinal imaging vertebral fractures. In analysis, the lumbar spine BMD Z-score was lowest (median, -1.0) 1...
Recurrent nephrotic syndrome (NS) is a severe problem after renal transplantation in patients with congenital of the Finnish type (NPHS1). The NPHS1 kidneys do not express nephrin, and antibodies against this major glomerular filter protein have been observed children recurrent NS. We evaluated here use plasma exchange (PE) therapy kidney retransplantation NS extended our studies on pathogenesis recurrence.Clinical data 65 who received 77 transplants between years 1986 2006 was collected....
Abstract The human leukocyte antigen ( HLA ) genotype has been shown to associate with tubulointerstitial nephritis TIN and uveitis syndrome TINU ). association of genes was examined in this nation‐wide study. genotyping performed 31 pediatric patients biopsy‐proven . All were by an ophthalmologist diagnose possible uveitis. Class II genotypes compared the Finnish reference population. We found a significant between alleles DQA1 *04:01 [risk ratio RR 5.0, 95% confidence interval CI...
Background. Low recipient age is still a risk factor for graft failure after kidney transplantation (Tx). Detailed prospective reports on long-term function in small children renal Tx are lacking. Methods. Forty-nine allograft recipients who received transplants before the of 5 years were followed prospectively. The most common disease was congenital nephrotic syndrome Finnish type. Twenty patients living related donors (LRD), and 29 cadaveric (CAD) recipients. All triple immunosuppression....
Children with pyelonephritis are at risk for renal damage. We assess the value of clinical signs and urological abnormalities in predicting scars children following pyelonephritis.A total 64 hospitalized (29 females 35 males, median age 2.9 years) underwent ultrasonography technetium labeled dimercapto-succinic acid (DMSA) scintigraphy imaging within 1 week diagnosis first pyelonephritis. Voiding cystourethrography was performed 8 weeks after diagnosis. Followup DMSA 58 patients 2 years...
We report our experience with maintenance peritoneal dialysis (PD) in small children.This is a retrospective analysis of the patient records all children under age 5 years treated continuous (CPD) between 1986 and 1994 Finland.Treatment was started patients were seen at outpatient clinic Hospital for Children Adolescents, University Helsinki, every 3 months. Between these visits, they had controls their local hospital 2-4 weeks.The most common primary renal disease 34 congenital nephrotic...
Studies have shown that early anaemia of prematurity cannot be prevented by iron or vitamin supplementation. We studied 35 infants birthweight less than 1520 g and mean gestational age 30.4 weeks who were fed either human milk alone supplemented with protein. The status the same in both groups but concentration haemoglobin was significantly higher at ages 4 to 10 protein infants. Reticulocytosis occurred earlier findings on reticulocytes similar 18 received no blood transfusions. conclude...
Shiga toxin-producing Escherichia coli (STEC) is a pathogen that causes gastroenteritis and bloody diarrhea but can lead to severe disease, such as hemolytic uremic syndrome (HUS). STEC serotype O78:H(-) rare among humans, infections are often asymptomatic. We detected sorbitol-fermenting O78:H(-):stx(1c):hlyA in blood fecal samples of 2-week-old boy who had bacteremia HUS his asymptomatic family members. The phenotypic genotypic characteristics the virulence properties this invasive were...