A5070997055- Research in Social Sciences
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
- Proteoglycans and glycosaminoglycans research
- Organ Transplantation Techniques and Outcomes
- Cancer-related gene regulation
- Renal Transplantation Outcomes and Treatments
- Mobile Learning in Education
- Online and Blended Learning
- Innovations in Medical Education
- Glycosylation and Glycoproteins Research
- Interprofessional Education and Collaboration
- Pancreatic function and diabetes
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Healthcare Policy and Management
- Mobile Health and mHealth Applications
- Polyomavirus and related diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Axon Guidance and Neuronal Signaling
- Adolescent and Pediatric Healthcare
- Empathy and Medical Education
- Nuclear Receptors and Signaling
- Metabolism, Diabetes, and Cancer
- Transplantation: Methods and Outcomes
Helsinki University Hospital
2004-2023
University of Helsinki
2004-2023
Children's Hospital
2012-2017
Finnish Red Cross
2008-2014
Jorvi Hospital
2006
Oulu University Hospital
2006
Kuopio University Hospital
2006
Tampere University
2006
Tampere University Hospital
2006
Päijät-Hämeen Keskussairaala
2005
An 18-kDa protein (designated herein as the heparin-binding growth-associated molecule, HB-GAM), expression of which in rat brain correlates to rapid postnatal developmental phase, was previously isolated and suggested have a role maturation growth (Rauvala, H. (1989) EMBO J. 8, 2933-2941). A with similar molecular mass, properties, same N-terminal sequence more recently also mitogen for NIH 3T3 cells (Milner, P. G., Li, Y.-T., Hoffman, R. M., Kodner, C. Siegel, N. R., Deuel, T. F. Biochem....
A cDNA library constructed from mRNA of rat brain was used to clone the that encodes 30-kDa heparin-binding protein (amphoterin) is developmentally regulated in and enhances neurite outgrowth cerebral neurons. peptide sequencing identified a dipolar sequence has been previously found studies high mobility group 1 protein: 184-amino acid cationic region followed by cluster 30 anionic residues. The encoding amphoterin also regulated; it strongly reduced quantity after rapid perinatal growth...
Amphoterin is a heparin-binding protein that developmentally regulated in brain and functionally involved neurite outgrowth. Unexpectedly, amphoterin has high mobility group 1 (HMG1)-type sequence. In the present study we have expressed cDNA baculovirus vector produced antibodies against recombinant several synthetic peptides. It was found encodes 30-kDa form of isolated from tissues, whereas co-purifying 28- 29-kDa proteins (p28 p29) closely related but distinct primary structures. Partial...
This paper proposes a novel approach to the development of competence-oriented higher education, national transformation aimed at harmonising and digitising undergraduate medical dental education in Finland.We apply phenomenography as viable qualitative method for research. To better understand teachers' expectations towards change educational paradigm, we need study experiences current practices education. The phenomenographic facilitates solid links between research, development,...
Biological Activities of HB-GAM11409 in cells and to produce a recombinant protein that would be free from other, contaminating heparin-binding polypeptide factors may influence biological studies, we have the present study expressed HB-GAM insect using baculovirus vector.The plasmid pAcYMl inserted with cDNA was used construct Auto- graph californica nuclear polyhedrosis virus (AcNPV).We demonstrate produced aid is immunochemically biochemically identical or very similar its naturally...
Receptors of the insulin/insulinlike growth factor (IGF) family have been implicated in regulation pancreatic β-cell and insulin secretion. The receptor-related receptor (IRR) is an orphan gene (Ir) subfamily. It expressed at considerably higher levels β cells than either or IGF-1 receptors, it has shown to engage heterodimer formation with receptors. To address whether IRR plays a physiologic role development secretion, we characterized mice lacking generated combined knockout Irand Irr. We...
A membrane-bound adhesive protein that promotes neurite outgrowth in brain neurons has been isolated from rat (Rauvala, H., and R. Pihlaskari. 1987. J. Biol. Chem. 262:16625-16635). The is an immunochemically distinct molecule with a subunit size of approximately 30 kD (p30). p30 abundant perinatal brain, but its content decreases rapidly after birth. In the present study amino-terminal sequence was determined by automated Edman degradations. single found, which not previously studied...
Expanding the criteria for deceased organ donors increases risk of delayed graft function (DGF) and complicates kidney transplant outcome. We studied whether donor neutrophil gelatinase-associated lipocalin (NGAL), a novel biomarker acute injury, could predict DGF after transplantation.We included 99 consecutive, their 176 recipients. For NGAL detection, serum urine samples were collected before operation. The analyzed using commercial enzyme-linked immunosorbent assay kit (serum) ARCHITECT...
BackgroundConsiderable disparities exist in the provision of paediatric renal replacement therapy (RRT) across Europe. This study aims to determine whether these arise from geographical differences occurrence disease, or country-level access-to-care factors may be responsible.
Abstract The human leukocyte antigen ( HLA ) genotype has been shown to associate with tubulointerstitial nephritis TIN and uveitis syndrome TINU ). association of genes was examined in this nation‐wide study. genotyping performed 31 pediatric patients biopsy‐proven . All were by an ophthalmologist diagnose possible uveitis. Class II genotypes compared the Finnish reference population. We found a significant between alleles DQA1 *04:01 [risk ratio RR 5.0, 95% confidence interval CI...
ABSTRACT Neural development relies on stringent regulation of key genes that mediate specialized function. TrkA is primarily expressed in neural crest-derived sensory and sympathetic neurons where it transmits critical survival information. We have identified a 457 base pair sequence upstream the murine first coding exon conserved human chick, sufficient for expression correct cells with appropriate timing. Mutation analysis consensus transcription factor binding domains within minimal...
BackgroundSensitive screening methods have revealed that many patients donor-specific human leucocyte antigen antibodies (DSAs) prior to transplantation, regardless of negative crossmatch results. The clinical significance pre-transplant (pre-Tx) DSAs for early graft function has remained unclear. Our aim was examine the association with delayed (DGF).
Neutrophil gelatinase-associated lipocalin (NGAL) is a marker for acute kidney injury. We studied whether serum NGAL predicts delayed graft function (DGF) and recovery of after transplantation. Serum was analyzed using commercial ELISA point-of-care (POC) (Triage®, Biosite) methods. samples were collected from 176 consecutive, deceased-donor recipients just before transplant surgery on day 1 14 The first 132 with both methods the remaining POC method. correlation between 0.89, p < 0.0001...
Because the results of short-term recombinant human growth hormone (rhGH) treatment in children with impairment after liver transplantation (LTx) have been promising, we studied long-term effects rhGH on and graft function LTx.Indications for were height standard deviation score (hSDS) below -2.0 or velocity SDS 0 LTx at least 18 months before inclusion. Eight growth-retarded treated more than 5 years.During first year, median rate improved from 3.3 to 7.0 cm/year. In second third remained...