A5004157739- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Cardiovascular and Diving-Related Complications
- Cerebrovascular and Carotid Artery Diseases
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Blood Pressure and Hypertension Studies
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Heart Rate Variability and Autonomic Control
- Cardiac Structural Anomalies and Repair
- Pericarditis and Cardiac Tamponade
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Congenital Heart Disease Studies
Haukeland University Hospital
2016-2025
GTx (United States)
2018-2025
University of Oslo
2025
Oslo University Hospital
2025
University of Bergen
2014-2024
Guy's and St Thomas' NHS Foundation Trust
2019-2022
Università Campus Bio-Medico
2022
Royal Brompton Hospital
2019-2021
Northwick Park Hospital
2019-2021
Cardiff University
2021
Objective To assess the safety and tolerability of treadmill exercise testing association revealed symptoms with outcome in apparently asymptomatic patients moderate to severe aortic stenosis (AS). Methods A retrospective cohort study 316 (age 65±12 years, 67% men) AS who underwent echocardiography modified Bruce tests (ETTs) at a specialist valve clinic. The measures were replacement (AVR), all-cause mortality or composite AVR mortality. Results At baseline, there 210 (66%) 106 (34%) AS....
Coronavirus disease 2019 (COVID-19) primarily affects the lungs but clinical manifestations vary markedly among patients involved. In more severe cases, COVID-19 can lead to acute respiratory distress syndrome (ARDS), multi-organ failure including cardiac injury and toxic shock with need for intensive care a ventilator support,1 while at opposite extreme signs symptoms be those of mild flu in many infection is asymptomatic. Since outbreak China, large number studies have consistently...
Background Worldwide, about 1.3 million annual ischaemic strokes (IS) occur in adults aged <50 years. Of these early-onset strokes, up to 50% can be regarded as cryptogenic or associated with conditions poorly documented causality like patent foramen ovale and coagulopathies. Key hypotheses/aims (1) Investigate transient triggers clinical/sub-clinical chronic risk factors IS the young; (2) use cardiac imaging methods exceeding state-of-the-art reveal novel sources for embolism; (3) search...
The impact of obstructive sleep apnea (OSA) on arterial stiffness is less studied. We aimed to investigate the prevalence and covariates increased pulse pressure (PP), a surrogate marker stiffness, in entire study population as well separate analyses normotensive hypertensive patients. Further, we also explored smoking brachial BP Between 2012 2019, total 6408 participants with suspected OSA underwent standard out-of-center respiratory polygraphy. was defined by an apnea-hypopnea index (AHI)...
To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe stenosis (AS).A retrospective study prospectively collected data 276 (mean age 75 ± 15 years, 51% male) transaortic [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and AS (aortic area <1.0 cm2). The outcome measure was all-cause mortality. Of patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up 3.2 1.8 years (range...
Saeed, Sahrai; Eriksen, Erlend; Aukrust, Pål; Halvorsen, Bente; Løland, Kjetil; Bleie, Øyvind; Bogale, Nigussie Author Information
Objectives The primary objectives were to identify the predictors of new permanent pacemaker implantation in patients with aortic stenosis (AS) undergoing transcatheter valve (TAVI). secondary investigate temporal changes following TAVI and its impact on long-term prognosis. Design Prospective observational cohort study AS TAVI. Setting Single-centre conducted at a tertiary hospital Western Norway between 2012 2019. Participants Among 600 consecutive severe who treated TAVI, 52 prior...
Background Studies in young patients with stroke identified coronary artery disease (CAD) as a main contributor to mortality. In the present NOR‐SYS (Norwegian Stroke Young Study), we aimed investigate prevalence of CAD, and impact on new vascular events Methods A total 385 ischemic stroke, aged ≤60 years, were included. CAD was defined history or positive imaging (computed tomography angiography). Results Mean age 49.6 68.1% men. The 25.2% (n=97) (nonobstructive, 9.6% [n=37]; obstructive,...
BACKGROUND: The incidence of young-onset ischemic stroke is rising, driven by cryptogenic (CIS) and patients without vascular risk factors. This study examines the burden associations modifiable traditional, nontraditional, female sex–specific factors with CIS, stratified clinically relevant patent foramen ovale (PFO), defined high-risk features atrial septal aneurysm or large right-to-left shunt. METHODS: We enrolled consecutive aged 18 to 49 years recent CIS frequency-matched stroke-free...
Background Exaggerated blood pressure response during exercise predicts future hypertension and cardiovascular events in general population different patients groups. However, its clinical prognostic implications with aortic stenosis have not been previously evaluated. Methods Results We retrospectively studied 301 moderate to severe asymptomatic (aged 65±12 years) who underwent echocardiography a modified Bruce treadmill test. An exaggerated was defined as peak systolic ≥190 mm Hg. abnormal...
Ischemic stroke survivors have high risk of cardiovascular morbidity and mortality even at young age, suggesting that early arterial aging is common among such patients.We measured aortic stiffness by carotid-femoral pulse wave velocity (PWV) in 205 patients (69% men) aged 15-60 years with acute ischemic the prospective Norwegian Stroke Young Study. High for age PWV was identified reference normogram.Patients were on average 49 ± 10 old, 34% had a history hypertension 37% metabolic syndrome...
Patients with degenerative aortic stenosis (AS) are often older and have systemic hypertension atherosclerosis, which all lead to increased stiffness. We aimed assess the determinants of carotid-femoral pulse wave velocity (cf-PWV), a direct measure stiffness, its association revealed symptoms clinical outcome in patients AS.We included 103 asymptomatic aged 66.6 ± 13.2 years (range 27-85 years, 69% males) moderate (n = 50) severe 53) AS. All underwent comprehensive echocardiography,...