A5066204114- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Stroke Rehabilitation and Recovery
- Neuroscience of respiration and sleep
- Botulinum Toxin and Related Neurological Disorders
- Cerebral Palsy and Movement Disorders
- Vestibular and auditory disorders
- Neurological Disorders and Treatments
- Psychosomatic Disorders and Their Treatments
- Biochemical effects in animals
- Balance, Gait, and Falls Prevention
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Ophthalmology and Eye Disorders
- Muscle activation and electromyography studies
- Neurological Complications and Syndromes
- Telemedicine and Telehealth Implementation
- Dysphagia Assessment and Management
- Long-Term Effects of COVID-19
University of Pavia
2016-2025
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2016-2025
Urology Foundation
2013-2024
Humboldt-Universität zu Berlin
2023
Charité - Universitätsmedizin Berlin
2023
Freie Universität Berlin
2023
Bridge University
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2022
To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for acute treatment migraine in a multicenter, double-blind, randomized, sham-controlled trial.A total 248 participants with episodic with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants repeat if had not improved 15 minutes.nVNS (n = 120) was superior 123) freedom at 30 (12.7% vs 4.2%; p 0.012)...
The aim of this study was to determine which supervised machine learning (ML) algorithm can most accurately classify people with Parkinson's disease (pwPD) from speed-matched healthy subjects (HS) based on a selected minimum set IMU-derived gait features. Twenty-two features were extrapolated the trunk acceleration patterns 81 pwPD and 80 HS, including spatiotemporal, pelvic kinematics, acceleration-derived stability indexes. After three-level feature selection procedure, seven considered...
Background Anti-CGRP monoclonal antibodies (anti-CGRP MAbs) are approved and available treatments for migraine prevention. Patients do not respond alike many countries have reimbursement policies, which hinder to those who might respond. This study aimed investigate clinical factors associated with good excellent response anti-CGRP MAbs at 6 months. Methods European multicentre, prospective, real-world study, including high-frequency episodic or chronic (CM) patients treated since March 2018...
The management of medication-overuse headache (MOH) is often difficult and no specific guidelines are available as regards the most practical effective approaches. In this study we defined tested a consensus protocol for MOH on large population patients distributed in different countries.The was based evidence from literature consolidated expertise members group. conducted according to multicentric interventional design with enrolment 376 subjects four centres Europe two Latin America....
In catastrophic situations such as pandemics, patients' healthcare including admissions to hospitals and emergency services are challenged by the risk of infection limitations resources. a setting, use telemedicine interventions has become extremely important. New technologies have proved helpful in pandemics solution improve quality life vulnerable patients persons with neurological diseases. Moreover, provide at-home solutions allowing clinicians telemonitor assess remotely, thus...
<h3>Importance</h3> Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) are structurally functionally related, yet different in their migraine-inducing properties. It remains unclear whether the lack of migraine induction can be attributed to only transient vasodilatory response after a 20-minute infusion VIP. <h3>Objective</h3> To determine 2-hour VIP would provoke attacks. <h3>Design, Setting, Participants</h3> A randomized,...
The interpretability of gait analysis studies in people with rare diseases, such as those primary hereditary cerebellar ataxia (pwCA), is frequently limited by the small sample sizes and unbalanced datasets. purpose this study was to assess effectiveness data balancing generative artificial intelligence (AI) algorithms generating synthetic reflecting actual abnormalities pwCA. Gait 30 pwCA (age: 51.6 ± 12.2 years; 13 females, 17 males) 100 healthy subjects 57.1 10.4; 60 40 were collected at...
Background and objective Multiple sclerosis is an inflammatory neurodegenerative disorder of the central nervous system that can lead to severe motor disability. The aim this study was verify health care effects integrated telerehabilitation approach involving dual-domains (motor cognitive) in people with multiple using a virtual reality rehabilitation compared home-based conventional rehabilitative intervention usual for patient-relevant outcomes (motor, cognitive participation). Methods...
People with chronic neurological diseases, such as Parkinson's Disease (PD) and Multiple Sclerosis (MS), often present postural disorders a high risk of falling. When difficulties in achieving outpatient rehabilitation services occur, solution to guarantee the continuity care may be telerehabilitation. This study intends expand scope our previously published research on impact telerehabilitation quality life an MS sample, testing this type intervention larger sample patients also including...
Neurological diseases causing motor/cognitive impairments are among the most common causes of adult-onset disability. More than one billion people affected worldwide, and this number is expected to increase in upcoming years, because rapidly aging population. The frequent lack complete recovery makes it desirable develop novel neurorehabilitative treatments, suited patients, better targeting specific To date, rehabilitation therapy can be aided by technological support robotic-based therapy,...
Background Medication-overuse headache (MOH) is a chronic disabling condition associated with high rate of relapse. Methods We evaluated whether the adoption electronic-assisted monitoring, advice and communication would improve outcome over follow-up 6 months in controlled, multicentre, multinational study conducted six centres located Europe Latin America. A total 663 MOH subjects were enrolled divided into two groups: Comoestas group was monitored an electronic diary alert system...
Abstract Background Migraine can manifest with an episodic or a chronic pattern in continuum of disease severity. Multiple factors are associated the progression from to chronic. One most consistently reported is overuse medications (MO) for acute treatment migraine attacks. The mechanisms through which MO facilitates transformation (EM) into (CM) elusive. In order provide insights these mechanisms, present study aims identify possible peripheral biomarkers two forms migraine, and presence...
Monoclonal antibodies (mABs) targeting the calcitonin gene-related peptide (CGRP) pathway represent first disease-specific preventive migraine therapy. Growing evidence suggests that they are effective in treatment of difficult-to-treat patients. In this study, we evaluated psychological predictors outcome with anti-CGRP monoclonal antibody erenumab patients chronic (CM).Seventy-five CM who had already failed at least 3 therapies received every 28 days for a period 12 months. Before...
The implementation of regular prolonged, and effective rehabilitation in people with Parkinson's disease is essential for ensuring a good quality life. However, the continuity care may find barriers related to economic, geographic, social issues. In these scenarios, telerehabilitation could be possible solution guarantee care.
Rimegepant, a novel oral calcitonin gene-related peptide receptor antagonist, has been recently approved for the acute migraine treatment. While its efficacy was confirmed in randomized clinical trials, no data is available regarding real-life effectiveness and tolerability. GAINER, prospective, multicentric study, aimed to evaluate rimegepant tolerability real-world setting. Our study involved 16 headache centers across Italy. The main outcomes were: i) 2 h pain freedom, ii) occurrence of...
Objective This study aims to evaluate the feasibility of an integrated multi-domain telerehabilitation (TR) system in stroke patients and observe whether there are changes quality life (QoL) levels undergoing TR treatments. Methods Patients were enrolled for a longitudinal multicentric pilot conducted six Italian research hospitals (IRCCS). The primary outcome was system, assessed by calculating treatment adherence collecting data from Technology Acceptance Model System Usability Scale...