A5054889505- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Muscle activation and electromyography studies
- Genetic Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- Acute Ischemic Stroke Management
- Migraine and Headache Studies
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Effects of Vibration on Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Nuclear Structure and Function
- Parkinson's Disease and Spinal Disorders
- Diabetes and associated disorders
- Virtual Reality Applications and Impacts
- Multiple Sclerosis Research Studies
- Anomaly Detection Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Muscle Physiology and Disorders
Sapienza University of Rome
2021-2025
The aim of this study was to determine which supervised machine learning (ML) algorithm can most accurately classify people with Parkinson's disease (pwPD) from speed-matched healthy subjects (HS) based on a selected minimum set IMU-derived gait features. Twenty-two features were extrapolated the trunk acceleration patterns 81 pwPD and 80 HS, including spatiotemporal, pelvic kinematics, acceleration-derived stability indexes. After three-level feature selection procedure, seven considered...
The interpretability of gait analysis studies in people with rare diseases, such as those primary hereditary cerebellar ataxia (pwCA), is frequently limited by the small sample sizes and unbalanced datasets. purpose this study was to assess effectiveness data balancing generative artificial intelligence (AI) algorithms generating synthetic reflecting actual abnormalities pwCA. Gait 30 pwCA (age: 51.6 ± 12.2 years; 13 females, 17 males) 100 healthy subjects 57.1 10.4; 60 40 were collected at...
This study aimed to assess the responsiveness rehabilitation of three trunk acceleration-derived gait indexes, namely harmonic ratio (HR), short-term longest Lyapunov's exponent (sLLE), and step-to-step coefficient variation (CV), in a sample subjects with primary degenerative cerebellar ataxia (swCA), investigate correlations between their improvements (∆), clinical characteristics, spatio-temporal kinematic features. The acceleration patterns antero-posterior (AP), medio-lateral (ML),...
Introduction: Gait impairments are common in People with Multiple Sclerosis (PwMS). Several studies have examined the clinometric properties of Inertial Measurement Units (IMUs), LDLJa identified as a robust metric for gait smoothness. However, its responsiveness and interpretability not been explored. Methods: This cross-sectional study at IRCCS Santa Lucia Hospital enrolled 44 PwMS (age: 28-71; EDSS: 0-6) 43 age- gait-speed-matched healthy participants (HP). Two physiotherapists conducted...
The aim of this study was to assess the ability multiscale sample entropy (MSE), refined composite (RCMSE), and complexity index (CI) characterize gait through trunk acceleration patterns in subjects with Parkinson’s disease (swPD) healthy subjects, regardless age or speed. 51 swPD 50 (HS) were acquired using a lumbar-mounted magneto-inertial measurement unit during their walking. MSE, RCMSE, CI calculated on 2000 data points, scale factors (τ) 1–6. Differences between HS at each τ, area...
The aims of this study were to assess the ability 16 gait indices identify instability and recurrent fallers in persons with Parkinson’s disease (pwPD), regardless age speed, investigate their correlation clinical kinematic variables. trunk acceleration patterns acquired during 55 pwPD age-and-speed matched healthy subjects using an inertial measurement unit. We calculated harmonic ratios (HR), percent recurrence, determinism (RQAdet), coefficient variation, normalized jerk score, largest...
The aim of this study was to assess the ability multiscale sample entropy (MSE), refined composite (RCMSE), and complexity index (CI) characterize gait through trunk acceleration patterns in subjects with Parkinson's disease (swPD) healthy subjects, regardless age or speed. 51 swPD 50 HS were acquired using a lumbar-mounted magneto-inertial measurement unit during their walking. MSE, RCMSE, CI calculated on 2000 data points, scale factors (τ) 1-6. Differences between at each τ, area under...
Abstract Stroke affects the interconnection between nervous and immune systems, leading to a down-regulation of immunity called stroke-induced immunosuppression (SII). The primary aim this study is investigate SII role as predictor functional, neurological, motor outcomes in neurorehabilitation setting (NRB). We conducted prospective observational enrolling post-acute stroke patients hospitalized for neurorehabilitation. At NRB admission (T 0 ) discharge 1 ), we assessed presence (defined by...
Background/Hypothesis: Motion sensitivity symptoms, like dizziness or unsteadiness, are frequently reported as non-headache symptoms of migraine. Postural imbalance has been observed in subjects with vestibular migraine, chronic and aura. We aimed to assess the ability largest Lyapunov’s exponent for short time – series (sLLE), which reflects cope internal perturbations during gait, detect differences local dynamic stability between individuals migraine without aura (MO) an episodic pattern...
: Stroke-induced immunosuppression (SII) represents a negative rehabilitative prognostic factor associated with poor motor performance at discharge from neurorehabilitation unit (NRB). This study aims to evaluate the association between SII and gait impairment NRB admission.
Background: Occupational therapy (OT) is an essential component of patient care, and it especially beneficial if focused on meaningful activities. For ataxic patients, traditional procedures are currently the most efficient, although without specific guidelines suggestions for virtual reality integration. In this context, study proposes Hybrid Smart Rehabilitation (HSR) based mixed (MR) as aid in overcoming limitations OT procedures. Methods: MR-HSR designed specifically patients developed...
Motion sensitivity symptoms, such as dizziness or unsteadiness, are frequently reported non-headache symptoms of migraine. Postural imbalance has been observed in subjects with vestibular migraine, chronic and aura. We aimed to assess the ability largest Lyapunov's exponent for a short time series (sLLE), which reflects cope internal perturbations during gait, detect differences local dynamic stability between individuals migraine without aura (MO) an episodic pattern attacks healthy (HS).