A5045315894- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Musculoskeletal pain and rehabilitation
- Ophthalmology and Eye Disorders
- Peripheral Nerve Disorders
- Pain Management and Placebo Effect
- Stroke Rehabilitation and Recovery
- Parkinson's Disease and Spinal Disorders
- Genetic Neurodegenerative Diseases
- Myofascial pain diagnosis and treatment
- Air Quality and Health Impacts
- Pain Management and Treatment
- Anesthesia and Pain Management
- Cardiovascular Syncope and Autonomic Disorders
- Motor Control and Adaptation
- Climate Change and Health Impacts
- Glycogen Storage Diseases and Myoclonus
- Psychosomatic Disorders and Their Treatments
Istituto Neurologico Mediterraneo
2015-2024
University of Pavia
2006-2012
Sapienza University of Rome
2003-2012
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2008-2012
Istituti di Ricovero e Cura a Carattere Scientifico
2012
University of Rome Tor Vergata
2012
University of Teramo
2012
Fondazione Santa Lucia
2012
Urology Foundation
2008-2009
Istituto di Sessuologia Clinica
2002
To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for acute treatment migraine in a multicenter, double-blind, randomized, sham-controlled trial.A total 248 participants with episodic with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants repeat if had not improved 15 minutes.nVNS (n = 120) was superior 123) freedom at 30 (12.7% vs 4.2%; p 0.012)...
Medication overuse could interfere with the activity of critical brain regions involved in supraspinal control pain signals at trigeminal and spinal level, leading to a sensitisation phenomenon responsible for chronic pain. We hypothesised that medication-overuse headache (MOH) patients might display abnormal processing stimuli level defective functioning diffuse noxious inhibitory controls. tested 31 MOH before (bWT) after (aWT) standard inpatient withdrawal treatment, 28 episodic migraine...
Medication-overuse headache (MOH) represents a severely disabling condition, with low response to prophylactic treatments. Recently, consistent evidences have emerged in favor of botulinum toxin type-A (onabotulinum A) as treatment chronic migraine. In 12-week double-blind, parallel group, placebo-controlled study, we tested the efficacy and safety onabotulinum A for MOH. total 68 patients were randomized (1:1) (n = 33) or placebo 35) received 16 intramuscular injections. The primary end...
To evaluate the 1-year effectiveness and tolerability of galcanezumab in real life prognostic indicators persistent response.High-frequency episodic migraine (HFEM) chronic (CM) patients treated with who completed a observation were enrolled. The primary outcomes assessed during 12 months (V1-V12) change monthly days (MMDs) from baseline response rates ≥50% MMDs (MMD RR). secondary changes pain intensity (numerical rating scale [NRS]) acute medication intake (MAMI).We enrolled 191 (77.5%...
People with Parkinson's disease (PD) often have a posture characterized by lateral trunk flexion poorly responsive to antiparkinsonian drugs. To examine the effects of rehabilitation programme (daily individual 90-minute-sessions, 5-days-a-week for 4-consecutive weeks) on and mobility, 22 PD patients mild severe flexion, without were studied. Patients evaluated using Unified Disease Rating Scale motor subscale (UPDRS-III) score, kinematic behavior was recorded means an optoelectronic system...
Abstract Background: Pain is one of the major nonmotor symptoms Parkinson's disease. We hypothesized that disease patients could show an early diffuse abnormal processing nociceptive inputs also in absence clinical pain syndrome and this represent physiopathological substrate to explain high incidence symptoms. Materials methods: used temporal summation threshold withdrawal reflex related sensation evaluate facilitation at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) without...
Aims: We tested the usability and usefulness of basic diagnostic headache diary (BDHD) for diagnosis migraine, tension-type medication-overuse in European Latin American countries. Methods: Patients were subdivided into two groups according to a 1:1 randomization list. Those group 1 sent BDHD before their first visit centre asked complete it at least month. 2 made without receiving BDHD. Results: A total 626 patients from nine countries 16 centres completed study. The entries 97.5% cases....
Objectives.— We investigated (1) a possible relationship between the functional activity of endocannabinoid system and facilitation pain processing in migraineurs with medication‐overuse headache, (2) effect withdrawal treatment on both. Background.— The antinociception includes prevention nociceptive pathways sensitization. sensitization has been demonstrated to be pivotal development maintenance chronic form migraine, including headache. Methods.— used temporal summation threshold reflex...
In cluster headache (CH), pathogenesis has been emphasized the role of posterior hypothalamus. It is part a supraspinal network involved in descending control pain, including diffuse noxious inhibitory (DNIC), which turn modulates pain processing. We hypothesized that CH during active phase facilitated temporal processing supported by abnormal functioning DNIC. studied functional activity DNIC evaluating effect cold pressor test (CPT) on summation threshold (TST) nociceptive withdrawal...
The nociceptive withdrawal reflex (NWR), a defensive response that allows from noxious stimulus, is reliable index of spinal nociception in humans. It has been shown various kinds stimuli (emotional, visual, auditory) can modulate the transmission and perception pain. aim present study was to evaluate, by means NWR, modulatory effect on circuitry olfactory with different emotional valence. magnitude NWR elicited electrical stimulation sural nerve measured while 18 subjects (9 women, 9 men)...
In migraine most studies report an interictal deficit of habituation visual-evoked potentials (VEP-hab) and reduced thresholds for phosphene induction (PT) by transcranial magnetic stimulation (TMS). We searched a possible correlation between VEP-hab PT in patients healthy controls to test whether they reflect the same pathophysiological abnormality.We assessed measured as percentage change N1/P1 amplitude over six blocks 100 responses 15 volunteers (HV) 13 episodic migraineurs without aura...
Neuroimaging data has implicated the temporal pole (TP) in migraine pathophysiology; density and functional activity of TP were reported to fluctuate accordance with cycle. Yet, exact link between morpho-functional abnormalities is unknown. Here, we examined whether non-invasive anodal transcranial direct current stimulation (tDCS) ameliorates abnormal interictal multimodal sensory processing patients migraine.We habituation visual evoked potentials median nerve somatosensory (SSEP) before...
Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality life. Spinal mechanisms may contribute to pathogenesis MS. Converging evidence from animal models neurophysiological clinical studies humans suggests a potential effect transcranial direct current stimulation (tc-DCS) on pain. application DCS, i.e., transcutaneous spinal DCS (ts-DCS), modulate nociception through inhibition reflexes. Therefore, ts-DCS...
Objective.—To evaluate trigemino‐cervical‐spinal reflexes (TCSRs) in a group of migraine patients during the pain‐free period. Background.—TCRSs are part complex nocifensive response involving cervical and upper limb muscles, modulated by supraspinal inhibitory pathways; it may, thus, be possible to use TCRSs explore trigeminal system migraineurs. Methods.—A total 43 without aura (MWoA, 32 patients) or with typical (MWA, 11 30 age‐ sex‐matched healthy subjects took study. were obtained...
A growing body of evidence supports the pivotal role hypothalamus in pathophysiology cluster headache (CH). On basis animal studies, it has been suggested that a hypothalamic dysfunction can lead to habituation deficit brainstem reflex responses, as result stress-like condition. Taking into account these findings, we tested hypothesis reflexes may be impaired CH patients. The phenomenon late components (R2 and R3) blink was studied 27 patients during period, 22 migraine interictally 20...
The nitric-oxide donor nitroglycerin (NTG) administration induces a facilitation of nociceptive pathways in episodic migraine. This study aims to test the hypothesis that induced spinal sensitization could be more pronounced patients affected by high-frequency migraine (HF-MIG) with respect low-frequency (LF-MIG). We enrolled 28 LF-MIG (1-5 days/month), 19 HF-MIG (6-14 and 21 healthy controls (HCs). Spinal was evaluated neurophysiological recording temporal summation threshold (TST)...