A5061901779- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Neurological Disorders and Treatments
- Vagus Nerve Stimulation Research
- Botulinum Toxin and Related Neurological Disorders
- Neurological Complications and Syndromes
- Maternal Mental Health During Pregnancy and Postpartum
- Neurological disorders and treatments
- Suicide and Self-Harm Studies
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Parkinson's Disease and Spinal Disorders
- Atomic and Subatomic Physics Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Sympathectomy and Hyperhidrosis Treatments
- Cardiovascular Syncope and Autonomic Disorders
University of Pavia
2016-2021
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2015-2021
To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for acute treatment migraine in a multicenter, double-blind, randomized, sham-controlled trial.A total 248 participants with episodic with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants repeat if had not improved 15 minutes.nVNS (n = 120) was superior 123) freedom at 30 (12.7% vs 4.2%; p 0.012)...
Introduction The mechanism of action non-invasive vagal nerve stimulation in the treatment migraine is elusive. We studied its effect a human model pain, nociceptive withdrawal reflex. Methods enrolled 10 healthy subjects who underwent active and sham randomized, cross-over, sham-controlled study. Non-invasive was delivered with gammaCore®. assessment reflex performed at baseline (T0) 5 (T5) 30 (T30) minutes after stimulation. Results significantly increased threshold to single stimulus both...
Menstrually-related headache and headaches associated with oestrogen withdrawal are common conditions, whose pathophysiology has not been completely elucidated. In this study we evaluated the influence of combined hormonal contraceptives (CHC) on pain threshold in women presenting migraine attacks during hormone-free interval.Eleven recurring exclusively oestrogen-withdrawal period were studied nociceptive flexion reflex, a neurophysiological assessment control systems, third week active...
Background: Early traumatic experiences and Stressful episodes appear to be associated the development perpetuation of chronic pain disorders dependence-related behaviors. Objective: The present study evaluated whether these factors can predictors, together with psychiatric conditions, outcome a detoxification treatment in patients suffering from migraine medication-overuse headache 2-month follow-up. Methods: Consecutive undergoing program as therapy for treating medication overuse at Pavia...
Pisa syndrome (PS) is a frequent postural complication of Parkinson's disease (PD). PS poorly responds to anti-parkinsonian drugs and the improvement achieved with neurorehabilitation tends fade in 6 months or less. Transcranial direct current stimulation (t-DCS) non-invasive neuromodulation technique that showed promising results improving specific symptoms different movement disorders. This study aimed evaluate role bi-hemispheric t-DCS as an add-on standardized hospital rehabilitation...
Introduction In this open label, single-arm trial we evaluated the efficacy of onabotulinum toxin-A in prevention high-frequency episodic migraine (8–14 days/month). Methods We enrolled 32 subjects (age 44.8 ± 11.9 years, 11.0 2.2 days, 11.5 2.1 headache 7 females). After a 28-day baseline period, underwent 4 subsequent treatments according to phase III research evaluating prophylaxis therapy (PREEMPT) paradigm, 12-weeks apart. The primary outcome was reduction monthly days from 12-week...
Background It is widely accepted that the brainstem plays a role in migraine pathophysiology. The periaqueductal gray matter (PAG) substantial component of descending pain modulatory network. Previous MRI studies by Welch et al demonstrated PAG iron levels are abnormally high both episodic and chronic migraine, suggesting hypothesis accumulation may be marker progressive dysfunction. increase can investigated with transcranial sonography (TCS) because heavy metal-induced hyperechogenicity.
We describe a patient affected by migraine with visual and somatosensory aura, whose symptoms were consistently attenuated noninvasive peripheral vagal nerve stimulation (nVNS) in multiple prospectively recorded attacks. When compared the current standard of care, nVNS significantly reduced duration aura all attacks ( n = 5) prevented three five The overall nVNS-treated auras was 19.0 ± 4.2 min, shorter than treated care (103.8 10.3 min). This single-case study requires confirmation larger...